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  4. NDUFS3 Antibody

NDUFS3 Antibody

  • 中文名稱：
    NDUFS3兔多克隆抗體
  • 貨號：
    CSB-PA197280
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA197280(NDUFS3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA197280(NDUFS3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: Mouse brain tissue, human fetal brain tissue, hela cells, Raw264.7 cells, NIH/3T3 cells, 293T cells, Primary antibody: CSB-PA197280(NDUFS3 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CI 30 antibody; CI 30KD antibody; CI-30kD antibody; Complex I 30KD antibody; Complex I 30kDa subunit antibody; COMPLEX I, MITOCHONDRIAL RESPIRATORY CHAIN, 30-KD SUBUNIT antibody; Complex I-30kD antibody; mitochondrial antibody; NADH coenzyme Q reductase antibody; NADH dehydrogenase (ubiquinone) Fe S protein 3 30kDa antibody; NADH dehydrogenase [ubiquinone] iron sulfur protein 3 mitochondrial antibody; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 antibody; NADH dehydrogenase ubiquinone 30 kDa subunit antibody; NADH-ubiquinone oxidoreductase 30 kDa subunit antibody; NADH-Ubiquinone Oxidoreductase Fe-S Protein 3 antibody; NDUFS3 antibody; NDUS3_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human NDUFS3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
  • 基因功能參考文獻：
    1. identified a novel Leigh syndrome causing NDUFS3 mutation and expanded the clinical spectrum caused by NDUFS3 mutations in this study. PMID: 30140060
    2. The results suggest that the impaired mitochondrial activity could be due to the broken interaction between DJ-1 and NDUFS3 and that downregulation of DJ-1 in sperm and testes contributes to AS pathogenesis. PMID: 29849492
    3. The NDUFS3 expressed in the temporal cortex in patient with late-onset Alzheimer's disease. PMID: 28242297
    4. High NDUFS3 expression is associated with IgA nephropathy. PMID: 25770168
    5. pH stability of w-t and Leigh syndrome mutant varied at extreme acidic pH. the molten globule like structure of w-t at pH1 was absent in case of the mutant protein. Both the w-t and mutant proteins showed multi-step thermal and Gdn-HCl induced unfolding PMID: 24028823
    6. NDUFS3 is down-regulated in serous ovarian adenocarcinoma PMID: 23446378
    7. Expressions of GRIM-19, NDUFS3, and extracellular matrix elements are correlated with invasive capabilities of breast cancer cell lines. PMID: 23630608
    8. a novel, biomarker potential of a mitochondrial complex I subunit protein, NDUFS3 - as a robust indicator of breast cancer progression and invasiveness as well as of hypoxia/necrosis in clinical specimens of invasive ductal carcinoma, was uncovered. PMID: 21867691
    9. Decreased protein levels of complex I 30-kDa subunit in fetal Down syndrome brains. PMID: 11771736

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  • 亞細胞定位：
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族：
    Complex I 30 kDa subunit family
  • 數據庫鏈接：

    HGNC: 7710

    OMIM: 603846

    KEGG: hsa:4722

    STRING: 9606.ENSP00000263774

    UniGene: Hs.502528



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