在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VSIG4 Recombinant Monoclonal Antibody

  • 中文名稱:
    VSIG4重組抗體
  • 貨號:
    CSB-RA896869MA1HU
  • 規格:
    ¥1320
  • 圖片:
    • The Binding Activity of VSIG4 with anti-VSIG4 antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human VSIG4(CSB-MP896869HU) at 2 μg/ml can bind Anti-VSIG4 recombinant antibody, the EC50 is 51.14-68.73 ng/mL.
  • 其他:

產品詳情

  • 產品描述:
    CSB-RA896869MA1HU是針對VSIG4(V-set and immunoglobulin domain-containing 4)靶點開發的重組單克隆抗體,適用于ELISA檢測。該抗體通過重組蛋白表達系統制備,具有高批次間一致性和特異性,能夠精準識別VSIG4分子。VSIG4作為B7家族共抑制分子成員,主要表達于組織駐留型巨噬細胞,通過調控T細胞活性參與免疫穩態維持,其異常表達與自身免疫性疾病、腫瘤免疫逃逸及炎癥性疾病密切相關。經實驗驗證,本產品在ELISA平臺中展現出優異的線性檢測范圍和低交叉反應性,適用于體外分析VSIG4蛋白表達水平,為研究其在免疫抑制微環境中的作用機制、探索慢性炎癥疾病模型中的免疫調控網絡,以及評估腫瘤相關巨噬細胞功能等基礎科研領域提供可靠工具。本品僅限科學研究使用,不適用于臨床診斷或其他用途。
  • Uniprot No.:
  • 基因名:
  • 別名:
    Complement receptor of the immunoglobulin superfamily antibody; CRIg antibody; Ig superfamily protein antibody; Protein Z39Ig antibody; UNQ317/PRO362 antibody; V set and immunoglobulin domain containing 4 antibody; V-set and immunoglobulin domain-containing protein 4 antibody; VSIG4 antibody; VSIG4_HUMAN antibody; Z39IG antibody
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human VSIG4 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    hIgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    12D12
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.
  • 基因功能參考文獻:
    1. Soluble VSIG4 levels are associated with the progression and recurrence of ovarian cancer, indicating that soluble VSIG4 may be used as a potential biomarker for predicting tumor prognosis. PMID: 28498255
    2. VSIG4 signaling provides an anti-immune evasion mechanism that prevents the outgrowth of intracellular bacteria in macrophages PMID: 27440002
    3. The VSIG4 upregulation by LMP1 was regulated at the transcriptional level via the NF-kB signaling axis. PMID: 28859984
    4. VSIG4 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    5. we concluded that let-7g-5p inhibits epithelial-mesenchymal transition (EMT) consistent with reduction of glioma stem cell (GSC) phenotypes by targeting VSIG4 in glioblastoma. PMID: 27634309
    6. Data indicate that rotein kinase calpha (PKCalpha) plays a role in downregulating complement receptor Ig (CRIg coded by V-set and Ig domain-containing protein 4 VSIG4) expression. PMID: 25687755
    7. complement receptor of the immunoglobulin superfamily-L-factor H protects glomerular mesangial cells from complement-mediated injury and proliferative lesions PMID: 25114177
    8. we identified VSIG4 as a potential diagnostic marker of severe preeclampsia. The determination of this gene may improve the prognostic assessment of severe preeclampsia. PMID: 24349325
    9. Data indicate that massive V-set and Ig domain-containing 4 VSIG4(+) cell infiltration throughout the non-small-cell lung cancer samples. PMID: 24862966
    10. we showed that a complement receptor of the Ig superfamily (CRIg, also known as Z39Ig), a receptor for complement fragments (C3b and iC3b), was expressed on a subset of intestinal macrophages in murine and human large intestine PMID: 21768202
    11. These results suggest that T cells can opposite T cell hyporesponsiveness through dampening Z39Ig inhibitory signals from macrophages and thus maintain their anti-viral function in chronic hepatitis B. PMID: 20399148
    12. hVSIG4 recombinant adenovirus-transfected DCs suppress T cell proliferation, cytokine production and activation marker expression with PMID: 19914289
    13. Results report the identification and characterization of a Complement Receptor of the Immunoglobulin superfamily, CRIg, that binds complement fragments C3b and iC3b. PMID: 16530040
    14. These data indicate that the macrophage Z39Ig is involved in the pathogenesis of inflammatory diseases through chemokine induction, which will promote the migration of inflammatory cells into the lesion area, and MMP-9 induction. PMID: 16882875
    15. The specific expression of VSIG4 on resting macrophages suggests that VSIG4 may be important for the maintenance of T cell unresponsiveness in healthy tissues. PMID: 17016562
    16. CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases PMID: 17051150

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages.
  • 數據庫鏈接:

    HGNC: 17032

    OMIM: 300353

    KEGG: hsa:11326

    STRING: 9606.ENSP00000363869

    UniGene: Hs.8904



主站蜘蛛池模板: 无码中文字幕av免费放dvd| 久久亚洲中文字幕伊人久久大| 97国产超碰一区二区三区| 欧美z0zo人禽交免费观看99| 国产成人精品视频ⅴa片软件竹菊| 久久无码av三级| 精品毛片乱码1区2区3区 | 影视av久久久噜噜噜噜噜三级| 天天av天天翘天天综合网| 国产成人精品三上悠亚| 小12萝裸体视频国产| 免费无码久久成人网站入口| 国产大片黄在线观看| 装睡被陌生人摸出水好爽| 97久章草在线视频播放| 狠狠亚洲狠狠欧洲2019| 国产专区国产av| 超碰香蕉人人网99精品| 亚洲 丝袜 制服 欧美 另类| 国内精品一区二区三区不卡| 乱中年女人伦av三区| 天天摸天天碰天天添| 国产精品被窝福利一区| 国内精品自线在拍2020不卡 | 日本午夜免费啪视频在线| 久久人午夜亚洲精品无码区| 女人被爽到呻吟gif动态图视看| 中国大陆高清aⅴ毛片| 极品人妻被黑人中出种子| 亚洲最大的熟女水蜜桃av网站| 婷婷五月综合缴情在线视频| 亚洲最大的成人网站| 国产成人片无码免费视频软件 | 国内精品久久久久影院嫩草| 亚洲综合欧美制服丝袜| 美女内射毛片在线看3d| 边啃奶头边躁狠狠躁| 人妻丰满熟妇av无码处处不卡| 日本熟妇乱人伦a片免费高清 | 99久久亚洲精品无码毛片| 肉体裸交丰满丰满少妇在线观看|