在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

TSPAN8 Recombinant Monoclonal Antibody

  • 中文名稱:
    TSPAN8 Recombinant Monoclonal Antibody
  • 貨號(hào):
    CSB-RA025166MA2HU
  • 規(guī)格:
    ¥1320
  • 圖片:
    • Untransfected MC38 cells (green line) and transfected Human TSPAN8 MC38 stable cells (red line) were stained with anti-TSPAN8 antibody (CSB-RA025166MA2HU) (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
    • HT29 cells were stained with Human IgG1&Igκ Isotype Control (CSB-RA011156MA1HU)(green line) and anti-TSPAN8 antibody (CSB-RA025166MA2HU) (2μg/1*106cells) (red line), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
    • The purity of TSPAN8 was greater than 95% as determined by SEC-HPLC
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    anti TSPAN8 antibody; CO029 antibody; Tetraspanin 8 antibody; Tetraspanin-8 antibody; TM4SF3 antibody; Transmembrane 4 superfamily member 3 antibody; TSN8_HUMAN antibody; Tspan 8 antibody; Tspan-8 antibody; TSPAN8 antibody; TSPAN8 antibody antibody; Tumor associated antigen CO 029 antibody; Tumor-associated antigen CO-029 antibody
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human TSPAN8 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    hIgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號(hào):
    6D4
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    FC
  • 推薦稀釋比:
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 基因功能參考文獻(xiàn):
    1. TSPAN8 mediated Wnt/beta-catenin pathway through binding to NOTCH2. The role of TSPAN8 in the drug resistance of gastric cancer. PMID: 29345284
    2. these data point to a crucial role of Co-029 in the modulation of colon cancer cell motility which could be related to the protumoral effect reported for this tetraspanin. Among surface molecules able to mediate Co-029 function, E-cadherin, EGFR and CD44 appear as likely candidates. PMID: 28418857
    3. Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder. PMID: 28777493
    4. Tetraspanin-8 has a role in promoting hepatocellular carcinoma metastasis by increasing ADAM12m expression PMID: 27270327
    5. LCMR1 modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo. PMID: 27375018
    6. Data indicate a regulatory role for tetraspanin 8 (Tspan8) in melanoma progression by modulating cell-matrix interactions through beta1 integrin - integrin-linked kinase (ILK) axis and establish Tspan8 as a negative regulator of ILK activity. PMID: 28188308
    7. TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes PMID: 27180358
    8. Knocking down TSPAN8 in AEG-1-overexpressing human hepatocellular carcinoma (HCC) cells markedly inhibited invasion and migration without affecting proliferation. TSPAN8 knockdown profoundly abrogated AEG-1-induced primary tumor and intrahepatic metastasis in an orthopic xenograft model in athymic nude mice PMID: 27339400
    9. Knockdown and knockout models revealed that CD151 and Tspan8 act as molecular facilitators in wound healing, angiogenesis and tumor progression. [review] PMID: 28408484
    10. Results provide evidence that TSPAN8 may contribute to the pathogenesis of lung cancer by promoting cell viability and proliferation. PMID: 27996312
    11. TSPAN8 is involved in tumor progression and is an independent prognostic classifier in patients with gastric cancer. PMID: 25711980
    12. This novel nuclear localization of TM4SF3 depends on androgen-induced nuclear localization of androgen receptor (AR) in both androgen-dependent and androgen-independent prostate cancer cell lines PMID: 26649804
    13. Our data suggest that TSPAN8-LEL may play an important role in mCRC cell invasion, and that the antibody we have developed could be a useful tool for inhibiting the invasion of TSPAN8-expressing mCRCs. PMID: 26562525
    14. Based on nasopharyngeal TSPAN8 gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants. PMID: 25261323
    15. Tspn8 was over-expressed in multiple clinical malignant glioma tissues, and its expression level correlated with the grade of tumors. PMID: 25680464
    16. CO-029 functions as a regulator of both cell-matrix and cell-cell adhesion. During colon cancer progression, CO-029 promotes cancer cell movement by deregulating cell adhesions. PMID: 22679508
    17. PMA-induced Tspan8-internalization promotes cell migration, but reduces matrix and cell adhesion. PMID: 20937409
    18. High TSPAN8 is associated with melanoma invasiveness. PMID: 21081927
    19. claudin-7-associated EpCAM is recruited into (tetraspanin-enriched membrane microdomains) and forms a complex with CO-029 and CD44v6 that facilitates metastasis formation PMID: 17579117
    20. overexpression of TM4SF3 in esophageal cancer conferred advantage to the invasion and metastasis of this destructive disease PMID: 18365756

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Tetraspanin (TM4SF) family
  • 組織特異性:
    Gastric, colon, rectal, and pancreatic carcinomas.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 11855

    OMIM: 600769

    KEGG: hsa:7103

    STRING: 9606.ENSP00000247829

    UniGene: Hs.170563



主站蜘蛛池模板: 亚洲国产日韩精品一区二区三区| 亚洲aⅴ无码专区在线观看q| 男男车车的车车网站w98免费| 人妻内射一区二区在线视频| 国产激情久久久久影院小草| 国产乱子伦精品免费视频| 日本黄网站免费| 髙清国产性猛交xxxand| 国内揄拍国内精品对白86| 男女扒开双腿猛进入免费看污| 久久精品国产网红主播| 亚洲中文字幕在线观看| 久久精品熟女亚州av麻豆 | 色婷婷香蕉在线一区二区| 韩产日产国产欧产| 亚洲欧美国产双大乳头| 欧美天天拍在线视频| 性史性农村dvd毛片| 狠狠色综合网站久久久久久久 | 无码一卡二卡三卡四卡| 成人性生交大免费看| 黑人粗长大战亚洲女| 日韩精品真人荷官无码| 亚洲色无码播放| 精品深夜av无码一区二区| 亚洲午夜私人影院在线观看| 秋霞国产精品一区二区| 激情综合一区二区三区| 朝鲜女人大白屁股ass| 蜜桃网站入口可看18禁| 国产成人啪精品午夜网站a片免费 国产精品人妻久久久久 | 亚洲一卡一卡二新区迎热烈讨论 | 无码专区3d动漫精品免费| 国产强奷在线播放免费| 色五月丁香六月欧美综合| 久久国产精品偷| 天天做天天欢摸夜夜摸狠狠摸| 免费国产午夜视频在线| 邻居少妇张开双腿让我爽一夜| 狠狠色成人综合网| 国模小黎自慰337p人体|