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TPBG Recombinant Monoclonal Antibody

  • 中文名稱：
    TPBG重組抗體
  • 貨號：
    CSB-RA024093MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • The Binding Activity of TPBG with Anti-TPBG monoclonal antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TPBG (CSB-MP024093HUB0) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.230-1.519 ng/mL.
    • The Binding Activity of Macaca fascicularis TPBG with Anti-TPBG monoclonal antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis TPBG (CSB-MP024093MOV) at 2 μg/mL can bind Anti-TPBG recombinant antibody, the EC50 is 1.672-2.181 ng/mL.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA024093MA1HU TPBG重組單克隆抗體是針對腫瘤相關抗原TPBG（5T4/WAIF1）開發的高特異性科研工具。TPBG作為跨膜糖蛋白，在胚胎發育階段參與細胞遷移調控，并在多種惡性腫瘤中異常高表達，其表達水平與腫瘤轉移及預后密切相關。本產品基于重組蛋白技術制備，經ELISA平臺嚴格驗證，展現出優異的抗原結合能力和批次穩定性，可精確識別天然構象及變性狀態下的TPBG靶點。適用于體外檢測細胞裂解液、組織提取物或培養上清中的TPBG蛋白定量分析，為探究腫瘤微環境調控、上皮間質轉化機制及轉移性癌癥分子標志物篩選等研究提供可靠支持。該抗體特別適用于建立TPBG表達水平與腫瘤惡性特征相關的體外研究模型，為靶向藥物開發和腫瘤生物學機制解析提供重要技術手段。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Trophoblast glycoprotein; 5T4 oncofetal antigen; 5T4 oncofetal trophoblast glycoprotein; T4 oncotrophoblast glycoprotein; M6P1; Wnt-activated inhibitory factor 1; WAIF1; TPBG; 5T4
  • 反應種屬：
    Human, Macaca mulatta
  • 免疫原：
    Recombinant Human TPBG protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    13C3
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization.
  • 基因功能參考文獻：
    1. In extravillous trophoblasts, 5T4 may function in epithelial-to-mesenchymal transition during placentation. The role of syncytiotrophoblast 5T4 is unknown, but its abundance in shed syncytial vesicles may signify route of sensitization of the maternal immune system. PMID: 28481180
    2. Collectively, these findings demonstrate that an anti-5T4 antibody-drug conjugate reduces the fraction of cancer stem cells (CSC), and prevents local recurrence and suggest a novel therapeutic approach for patients with head and neck squamous cell carcinoma. PMID: 27780858
    3. We obtained GWS evidence (P < 2.7 x 10(-6)) for gene-based association in the total sample with a novel locus, TPBG (P = 1.8 x 10(-6)). PMID: 28183528
    4. In conclusion, the present study provided evidence that TPBG is involved in PDAC metastasis, and that TPBG and its associated signaling pathways may be a suitable target for pancreatic ductal adenocarcinoma therapy. PMID: 25738465
    5. 5T4 expression is mechanistically associated with the directional movement of cells through epithelial mesenchymal transition, facilitation of CXCL12/CXCR4 chemotaxis, blocking of canonical Wnt/beta-catenin while favouring non-canonical pathway signalling PMID: 25066861
    6. Tyrosine 325 plus the leucine-rich repeat 1 surface centered on a second exposed aromatic residue, phenylalanine 97, are essential for inhibition of Wnt/beta-catenin signaling. PMID: 24582434
    7. The surface expression of 5T4 marks the use of the CXCR4 rather than the CXCR7 receptor, with distinct consequences for CXCL12 exposure. PMID: 22956548
    8. 5T4 is a potential new antigen for targeted therapies such as immunotherapy in MPM, as it is overexpressed on mesothelioma cells and recognised by 5T4-specific cytotoxic T-cells. PMID: 22498111
    9. Glycosylation and epitope mapping of the 5T4 glycoprotein oncofoetal antigen PMID: 11903056
    10. Results sugest that 5T4 is a transient marker of human embryonic stem cell differentiation & that 5T4 phenotype, colony seeding density and culture conditions influence the maintenance of pluripotent hES cells and their differentiation to neural lineages. PMID: 16616918
    11. there is a repertoire of CD8 T cell recognition of 5T4 in normal human donors and some candidate HLA-A*0201 epitopes have been identified PMID: 16646078
    12. the mRNA expression of trophoblast glycoprotein is up-regulated in cells circulating within blood from women with preeclampsia. PMID: 17978129
    13. 5T4-based cancer vaccine: cytotoxic T lymphocyte epitopes identified in Trovax-vaccinated colorectal cancer patients PMID: 18567615
    14. colorectal cancer patients who had preexisting cell proliferative responses to 5T4 were longer-term survivors PMID: 18833005

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  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性：
    Expressed by all types of trophoblasts as early as 9 weeks of development. Specific for trophoblastic cells except for amniotic epithelium. In adult tissues, the expression is limited to a few epithelial cell types but is found on a variety of carcinoma.
  • 數據庫鏈接：

    HGNC: 12004

    OMIM: 190920

    KEGG: hsa:7162

    STRING: 9606.ENSP00000358765

    UniGene: Hs.71947



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