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  4. SNRPD1 Recombinant Monoclonal Antibody

SNRPD1 Recombinant Monoclonal Antibody

  • 中文名稱：
    SNRPD1重組抗體
  • 貨號：
    CSB-RA022332MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA022332MA1HU diluted at 1:50 and staining in paraffin-embedded human breast tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA022332MA1HU diluted at 1:50 and staining in paraffin-embedded human stomach tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-mouse polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Immunofluorescence staining of A549 cell with CSB-RA022332MA1HU at 1:20, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Mouse IgG(H+L).
    • Overlay Peak curve showing Hela cells stained with CSB-RA022332MA1HU (red line) at 1:100. The cells were fixed in 4% formaldehyde (15min) and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA022332MA1HU重組單克隆抗體是針對SNRPD1靶點開發(fā)的高特異性科研試劑，該靶標作為小核核糖核蛋白復(fù)合體的核心組分，在RNA剪接和轉(zhuǎn)錄調(diào)控中發(fā)揮關(guān)鍵作用，其異常表達與細胞周期紊亂及腫瘤發(fā)生密切相關(guān)。本產(chǎn)品經(jīng)多種實驗平臺驗證，適用于ELISA、免疫組化、免疫熒光及流式細胞技術(shù)，推薦工作濃度在IHC/IF/FC應(yīng)用中均保持1:20-1:200的寬泛稀釋范圍，展現(xiàn)卓越的批次穩(wěn)定性和抗原結(jié)合活性。在基礎(chǔ)研究領(lǐng)域可廣泛應(yīng)用于探究RNA加工機制、腫瘤分子病理特征、基因表達調(diào)控網(wǎng)絡(luò)等方向，特別適用于體外培養(yǎng)細胞模型的組織定位分析、蛋白互作研究以及特定細胞亞群的表型鑒定，為探索疾病相關(guān)分子通路提供可靠工具。該產(chǎn)品嚴格遵循科研用途標準制備，建議配合陽性和陰性對照實驗以優(yōu)化檢測條件。
  • Uniprot No.：
  • 基因名：
    SNRPD1
  • 別名：
    AA407109 antibody; AL023031 antibody; HsT2456 antibody; Sm D1 antibody; Sm-D autoantigen antibody; Sm-D1 antibody; Small nuclear ribonucleoprotein D1 polypeptide antibody; Small nuclear ribonucleoprotein Sm D1 antibody; SmD autoantigen antibody; SMD1 antibody; SMD1_HUMAN antibody; snRNP core protein D1 antibody; SNRPD antibody; Snrpd1 antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human SNRPD1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    24E2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:20-1:200
    FC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.
  • 基因功能參考文獻：
    1. Data show that the elevation of cerebrospinal fluid anti-Sm antibodies through transudation from systemic circulation due to damaged blood-brain barrier (BBB) plays a critical role in the pathogenesis of acute confusional state (ACS). PMID: 25273532
    2. The interaction of SMN with the spliceosomal SmD1 (also known as SNRPD1), severely decreases SMN-coilin interaction and prevents Cajal body assembly. PMID: 24413165
    3. Overexpression of SNRPD1 is associated with highly aggressive breast cancers. PMID: 23358685
  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族：
    SnRNP core protein family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11158

    OMIM: 601063

    KEGG: hsa:6632

    STRING: 9606.ENSP00000300413

    UniGene: Hs.464734



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