在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. PRKAR2B Recombinant Monoclonal Antibody

PRKAR2B Recombinant Monoclonal Antibody

  • 中文名稱：
    PRKAR2B Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA573401A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing jurkat cells stained with CSB-RA573401A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AI451071 antibody; AW061005 antibody; cAMP dependent protein kinase type II beta regulatory chain antibody; cAMP dependent protein kinase type II beta regulatory subunit antibody; cAMP-dependent protein kinase type II-beta regulatory subunit antibody; H RG363E19.2 antibody; KAP3_HUMAN antibody; MGC116401 antibody; Pkarb2 antibody; PRKAR 2 antibody; PRKAR2 antibody; PRKAR2B antibody; Protein kinase cAMP dependent regulatory type II beta antibody; RATDNA antibody; RII beta antibody; RII(beta) antibody; RIIbeta antibody; WUGSC:H RG363E19.2 antibody
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human PRKAR2B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    6D12
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
  • 基因功能參考文獻：
    1. Study identified the overexpression of PRKAR2B in castration-resistant prostate cancer (CRPC) mouse models and patients, and showed it promoted CRPC cell proliferation, invasion and survival by mainly modulates cell cycle gene expression. These results provide evidence that PRKAR2B is a novel oncogenic gene in CRPC. PMID: 28008150
    2. Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit. PMID: 26158466
    3. Because of limited power, PRKAR2B's role in antipsychotic-induced weight gain is unclear, but biological evidence suggests that PRKAR2B may be involved PMID: 24737441
    4. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 21068099
    5. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
    6. lipolytic catecholamine resistance of sc adipocytes in polycystic ovary syndrome is probably due to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of protein kinase A, and hormone-sensitive lipase PMID: 12727985
    7. Nuclear RII beta can act as a repressor of CREB transcriptional activity in T cells, providing a potential functional significance for aberrant levels of nuclear RII beta in systemic lupus erythematosus T cells. PMID: 14500661
    8. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta PMID: 14744463
    9. serine 114 phosphorylation and nuclear localization of RIIbeta controls the regulation of IL-2 gene expression in T cells. PMID: 15187164
    10. Loss of PRKAR2B protein due to a post-transcriptional mechanism in ACA-S is a new mechanism of cAMP pathway dysregulation in adrenocortical tumorigenesis. PMID: 18505904
    11. PKA RII(beta) is responsible for increased glucocorticoid sensitivity, critical for cAMP-mediated synergistic cell killing in CEM cells PMID: 18544528
    12. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
  • 蛋白家族：
    CAMP-dependent kinase regulatory chain family
  • 組織特異性：
    Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 數據庫鏈接：

    HGNC: 9392

    OMIM: 176912

    KEGG: hsa:5577

    STRING: 9606.ENSP00000265717

    UniGene: Hs.433068



主站蜘蛛池模板： 免费的av网站手机版| 欧美xxxx做受欧美1314| 亚洲国产99精品国自产拍| 国产av国片精品一区二区| 日韩精品久久久久久免费| 国产suv精品一区| 亚洲精品第一国产综合境外资源| 国产农村毛卡片| 国产麻传媒精品国产av| 亂倫近親相姦中文字幕| 亚洲成在人线免费观看| 无码av中文一区二区三区| 欧美老熟妇乱子| 18精品久久久无码午夜福利| 日日做夜狠狠爱欧美黑人| 97国产一区二区三区四区久久| 国产初高中生粉嫩无套第一次| 不卡无码人妻一区二区三区| 国模杨依粉嫩蝴蝶150p| 狠狠色噜噜狠狠狠狠av| 无码写真精品永久福利在线| 国产一卡2卡3卡四卡精品app| 免费国精产品wnw2544| 亚洲国产天堂久久综合| 精品久久久久久777米琪桃花| 亚洲成av人片在线观看下载| 久久久久无码国产精品不卡| 性欧美性另类巨大| 国产男生夜间福利免费网站| 久久不见久久见免费视频7| 国产精品爱久久久久久久| 亚洲日韩乱码中文字幕| 色噜噜噜亚洲男人的天堂| 情侣作爱视频网站| 亚洲图片自拍偷图区| 中文资源在线天堂库8| 国产国拍精品av在线观看按摩 | 日日碰狠狠躁久久躁婷婷| 8av国产精品爽爽ⅴa在线观看 | 中国熟妇牲交视频| 精品av一区二区久久久|