在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-PRKAR2B (Ser114) Antibody

  • 中文名稱:
    磷酸化-PRKAR2B (Ser114)兔多克隆抗體
  • 貨號:
    CSB-PA039825
  • 規格:
    ¥2454
  • 圖片:
    • Western blot analysis of extracts from COS-7 cells treated with PMA using PKA-R2β (Phospho-Ser114) Antibody.The lane on the right is treated with the antigen-specific peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRKAR2B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Peptide sequence around phosphorylation site of Serine114(R-R-A-S(p)-V) derived from Human PKA-R2β.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
  • 基因功能參考文獻:
    1. Study identified the overexpression of PRKAR2B in castration-resistant prostate cancer (CRPC) mouse models and patients, and showed it promoted CRPC cell proliferation, invasion and survival by mainly modulates cell cycle gene expression. These results provide evidence that PRKAR2B is a novel oncogenic gene in CRPC. PMID: 28008150
    2. Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit. PMID: 26158466
    3. Because of limited power, PRKAR2B's role in antipsychotic-induced weight gain is unclear, but biological evidence suggests that PRKAR2B may be involved PMID: 24737441
    4. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 21068099
    5. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
    6. lipolytic catecholamine resistance of sc adipocytes in polycystic ovary syndrome is probably due to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of protein kinase A, and hormone-sensitive lipase PMID: 12727985
    7. Nuclear RII beta can act as a repressor of CREB transcriptional activity in T cells, providing a potential functional significance for aberrant levels of nuclear RII beta in systemic lupus erythematosus T cells. PMID: 14500661
    8. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta PMID: 14744463
    9. serine 114 phosphorylation and nuclear localization of RIIbeta controls the regulation of IL-2 gene expression in T cells. PMID: 15187164
    10. Loss of PRKAR2B protein due to a post-transcriptional mechanism in ACA-S is a new mechanism of cAMP pathway dysregulation in adrenocortical tumorigenesis. PMID: 18505904
    11. PKA RII(beta) is responsible for increased glucocorticoid sensitivity, critical for cAMP-mediated synergistic cell killing in CEM cells PMID: 18544528
    12. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
  • 蛋白家族:
    CAMP-dependent kinase regulatory chain family
  • 組織特異性:
    Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 數據庫鏈接:

    HGNC: 9392

    OMIM: 176912

    KEGG: hsa:5577

    STRING: 9606.ENSP00000265717

    UniGene: Hs.433068



主站蜘蛛池模板: 人妻激情另类乱人伦人妻| 成人做受视频试看120秒| 国产成久久免费精品av片| 无码专区亚洲制服丝袜| 精品国偷自产在线视频99| 国产在线精品一区二区三区| 日韩免费视频| 国产99久久久国产精品~~牛| 久久精品国产久精国产一老狼| 69成人免费视频无码专区| 欧美裸体xxxx极品| 精品国模一区二区三区| 一个人看的www视频免费观看 | 狠狠躁夜夜躁人人爽天天古典 | 黑人巨大精品欧美黑寡妇| 亚洲精品久久久久久无码色欲四季 | 麻豆果冻传媒2021精品传媒一区| 人人插人人插人人爽| 131美女爱做视频| 日韩人妻无码精品一专区| 婷婷四虎东京热无码群交双飞视频 | 精品一卡二卡三卡| 亚洲精品夜夜夜妓女网| 女人摸下面自熨视频在线播放| 亚洲va成无码人在线观看天堂| 成年女人毛片免费视频| 波多野结衣av一区二区全免费观看 | 国产女人高潮抽搐喷水视频| 亚洲 欧美 中文 在线 视频| 精品无码久久久久久久久| 99日本精品永久免费久久| 亚洲精品一卡2卡三卡4卡| 特级做a爰片毛片免费69| 国产真实交换配乱婬95视频| 毛片免费观看天天干天天爽| 欧美3p两根一起进高清视频| 午夜视频体内射.com.com| 日本成熟老妇乱| 真实国产乱子伦在线视频| 在线观看人成视频免费| 校园春色~综合网|