在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-PRKAR2B (Ser114) Antibody

  • 中文名稱:
    磷酸化-PRKAR2B (Ser114)兔多克隆抗體
  • 貨號:
    CSB-PA039825
  • 規格:
    ¥2454
  • 圖片:
    • Western blot analysis of extracts from COS-7 cells treated with PMA using PKA-R2β (Phospho-Ser114) Antibody.The lane on the right is treated with the antigen-specific peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRKAR2B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Peptide sequence around phosphorylation site of Serine114(R-R-A-S(p)-V) derived from Human PKA-R2β.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
  • 基因功能參考文獻:
    1. Study identified the overexpression of PRKAR2B in castration-resistant prostate cancer (CRPC) mouse models and patients, and showed it promoted CRPC cell proliferation, invasion and survival by mainly modulates cell cycle gene expression. These results provide evidence that PRKAR2B is a novel oncogenic gene in CRPC. PMID: 28008150
    2. Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit. PMID: 26158466
    3. Because of limited power, PRKAR2B's role in antipsychotic-induced weight gain is unclear, but biological evidence suggests that PRKAR2B may be involved PMID: 24737441
    4. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 21068099
    5. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
    6. lipolytic catecholamine resistance of sc adipocytes in polycystic ovary syndrome is probably due to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of protein kinase A, and hormone-sensitive lipase PMID: 12727985
    7. Nuclear RII beta can act as a repressor of CREB transcriptional activity in T cells, providing a potential functional significance for aberrant levels of nuclear RII beta in systemic lupus erythematosus T cells. PMID: 14500661
    8. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta PMID: 14744463
    9. serine 114 phosphorylation and nuclear localization of RIIbeta controls the regulation of IL-2 gene expression in T cells. PMID: 15187164
    10. Loss of PRKAR2B protein due to a post-transcriptional mechanism in ACA-S is a new mechanism of cAMP pathway dysregulation in adrenocortical tumorigenesis. PMID: 18505904
    11. PKA RII(beta) is responsible for increased glucocorticoid sensitivity, critical for cAMP-mediated synergistic cell killing in CEM cells PMID: 18544528
    12. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
  • 蛋白家族:
    CAMP-dependent kinase regulatory chain family
  • 組織特異性:
    Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 數據庫鏈接:

    HGNC: 9392

    OMIM: 176912

    KEGG: hsa:5577

    STRING: 9606.ENSP00000265717

    UniGene: Hs.433068



主站蜘蛛池模板: 国产亚洲久久久久久久| 亚洲一区二区三区成人网站| 久久精品欧美日韩精品| 日本中文字幕人妻不卡dvd| 亚洲一卡2卡三卡4卡无卡下载 | 亚洲欧美日韩一区二区| 玩弄中年熟妇正在播放| 免费国产a国产片高清网站| 成人做爰视频www网站| 日产精品久久久久久久蜜臀| 久久亚洲精品11p| www国产亚洲精品久久麻豆| 午夜成人无码片在线观看影院| 亚洲乱码中文字幕手机在线| 男人扒开女人腿桶到爽免费| 国产精品香港三级国产av| 国产成+人+综合+亚洲专区| 人妻精品人妻无码一区二区三区| 少妇系列之白嫩人妻| 韩国三级hd中文字幕| 国产美女精品自在线拍免费| 国语精品自产拍在线观看网站 | 少妇与大狼拘作爱性a| 中文无码精品a∨在线观看不卡| 国产与黑人在线播放| 欧美18videosex性欧美黑吊| 女人喷液抽搐高潮视频| 男女爽爽午夜18污污影院| 天堂亚洲国产中文在线| 国产精品亚韩精品无码a在线| 久久精品无码一区二区日韩av| 日韩精品一区二区av在线| 国产白嫩护士被弄高潮| 欧美性生 活18~19| 国产偷伦视频片免费视频| 亚色九九九全国免费视频| 国产成人无码午夜视频在线观看| 亚洲va国产va天堂va久久| 天天摸日日摸爽爽狠狠| 国产精品久久人妻互换| 性欧美大战久久久久久久久|