在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Phospho-PRKAR2B (Ser114) Antibody

  • 中文名稱:
    磷酸化-PRKAR2B (Ser114)兔多克隆抗體
  • 貨號:
    CSB-PA039825
  • 規格:
    ¥2454
  • 圖片:
    • Western blot analysis of extracts from COS-7 cells treated with PMA using PKA-R2β (Phospho-Ser114) Antibody.The lane on the right is treated with the antigen-specific peptide.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) PRKAR2B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Peptide sequence around phosphorylation site of Serine114(R-R-A-S(p)-V) derived from Human PKA-R2β.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.
  • 基因功能參考文獻:
    1. Study identified the overexpression of PRKAR2B in castration-resistant prostate cancer (CRPC) mouse models and patients, and showed it promoted CRPC cell proliferation, invasion and survival by mainly modulates cell cycle gene expression. These results provide evidence that PRKAR2B is a novel oncogenic gene in CRPC. PMID: 28008150
    2. Release of pRIIbeta in the presence of cAMP is reduced by calcium, whereas autophosphorylation at the phosphorylation site inhibits holoenzyme reassociation with the catalytic subunit. PMID: 26158466
    3. Because of limited power, PRKAR2B's role in antipsychotic-induced weight gain is unclear, but biological evidence suggests that PRKAR2B may be involved PMID: 24737441
    4. Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 21068099
    5. Clinical trial and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20195266
    6. lipolytic catecholamine resistance of sc adipocytes in polycystic ovary syndrome is probably due to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of protein kinase A, and hormone-sensitive lipase PMID: 12727985
    7. Nuclear RII beta can act as a repressor of CREB transcriptional activity in T cells, providing a potential functional significance for aberrant levels of nuclear RII beta in systemic lupus erythematosus T cells. PMID: 14500661
    8. there are abnormalities in [3H]cAMP binding and catalytic activity kinase A in brain of depressed suicide victims, which could be due to reduced expression of RIIbeta and Cbeta PMID: 14744463
    9. serine 114 phosphorylation and nuclear localization of RIIbeta controls the regulation of IL-2 gene expression in T cells. PMID: 15187164
    10. Loss of PRKAR2B protein due to a post-transcriptional mechanism in ACA-S is a new mechanism of cAMP pathway dysregulation in adrenocortical tumorigenesis. PMID: 18505904
    11. PKA RII(beta) is responsible for increased glucocorticoid sensitivity, critical for cAMP-mediated synergistic cell killing in CEM cells PMID: 18544528
    12. both the constitutive and cAMP-induced release of TNFR1 exosome-like vesicles occur via PKA-dependent pathways that are regulated by the anchoring of RIIbeta to BIG2 via AKAP domains B and C PMID: 18625701

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.
  • 蛋白家族:
    CAMP-dependent kinase regulatory chain family
  • 組織特異性:
    Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.
  • 數據庫鏈接:

    HGNC: 9392

    OMIM: 176912

    KEGG: hsa:5577

    STRING: 9606.ENSP00000265717

    UniGene: Hs.433068



主站蜘蛛池模板: 精品一二三区久久aaa片| 亚洲欧洲国产综合aⅴ无码| 精品无人乱码高清在线观看| 日本乱人伦aⅴ精品| 性做久久久久久久免费看| 性欧美熟妇videofreesex| 色狠狠色噜噜av天堂一区| 国产精品人妻系列21p| 国产亚洲精品视觉盛宴| 国产国语亲子伦亲子| 无码人妻精品中文字幕| 窝窝午夜看片成人精品| 96亚洲精华国产精华精华液| 国产波霸爆乳一区二区| 国产精品美女久久久久久| 一本久久a久久免费精品不卡| 真人一进一出120秒试看| 无码精品国产d在线观看| 试看120分钟做受小视频| 高清精品一区二区三区| 色 成人 亚洲| 亚洲精品无码久久久久不卡| 色狠狠成人综合网| www国产亚洲精品久久网站| 亚洲精品久久国产精品浴池| 蜜臀精品国产高清在线观看| 久久综合给合久久狠狠97色| 丰满熟女人妻中文字幕免费| 久久国产劲暴∨内射新川| 色综合天天天天综合狠狠爱| 激情综合丁香五月| 欧美日韩在线视频| 国产精品亚洲精品日韩已满| 亚洲 欧洲 日韩 综合色天使| 国产精品视频一区国模私拍| 国产伦精品一区二区三区| 国产成人av国语在线观看| 亚洲自偷自拍另类11p| 国产成人无码aⅴ片在线观看| 亚洲午夜久久久久妓女影院| 亚洲综合激情五月丁香六月|