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  4. PRDX5 Recombinant Monoclonal Antibody

PRDX5 Recombinant Monoclonal Antibody

  • 中文名稱：
    PRDX5 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA161234A0HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA161234A0HU diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • Overlay Peak curve showing Hela cells stained with CSB-RA161234A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for 10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10, 000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PRDX5
  • 別名：
    ACR1 antibody; Alu co repressor 1 antibody; Alu corepressor 1 antibody; Antioxidant enzyme B166 antibody; AOEB166 antibody; B166 antibody; epididymis secretory protein Li 55 antibody; HEL-S-55 antibody; Liver tissue 2D-page spot 71B antibody; mitochondrial antibody; Peroxiredoxin 5; mitochondrial antibody; Peroxiredoxin V antibody; Peroxiredoxin-5 antibody; Peroxisomal antioxidant enzyme antibody; PLP antibody; PMP20 antibody; PRDX 5 antibody; PRDX5 antibody; PRDX5_HUMAN antibody; PRDX6 antibody; Prx-V antibody; PRXV antibody; SBBI10 antibody; Thioredoxin peroxidase PMP20 antibody; Thioredoxin reductase antibody; TPx type VI antibody
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human PRDX5 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    23A8
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
  • 基因功能參考文獻：
    1. High PRX5 expression is associated with gastric cancer. PMID: 28535004
    2. Results found that Prx5 was increased in the cellular model of Alzheimer's disease (AD) and, identify a role for Prx5 as an upregulator of Cdk5 activation via reactive oxygen species-mediated Ca2+-mediated calpain activation. PMID: 28358580
    3. The PRX5 can be used as a predictive biomarker and serves as a putative therapeutic target for the development of clinical treatments for human CRC. PMID: 28431931
    4. peroxisomal PRDX5 protects oligodendrocytes against peroxisomal and mitochondrial oxidative stress. PMID: 25772011
    5. show here how the ligand-observed saturation transfer difference (STD) experiment and the PRDX5 protein-observed 15N-HSQC experiment, two popular NMR screening experiments, can be used to compare the binding modes of analogous fragments PMID: 25025339
    6. PRX5 is either consumed or its production is impaired in severe stroke PMID: 24385276
    7. This study demonistrated that overexpression of mitochondrial PRDX5 protects SH-SY5Y cells against the ROS/RNS-dependent neuronal death induced by MPP+. PMID: 23216451
    8. The promoter region critical for Prx5 gene regulation to which the novel negative transcription regulator, GATA1 binds in human breast cancer cell lines. PMID: 22020876
    9. basal expression of the human PRDX5 gene is regulated by GABP PMID: 20937353
    10. analysis of fragment molecules that bind the human peroxiredoxin 5 active site PMID: 20305821
    11. Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism PMID: 11832487
    12. the expression of peroxiredoxin 5 is upregulated in osteoarthritis PMID: 12417342
    13. multiple subcellular targeting of peroxiredoxin 5 in mammalian cells can be implicated in antioxidant protective mechanisms under nonpathological conditions PMID: 14732291
    14. Transfection of PRXVI protects immortalized human WI-38 and murine NIH3T3 fibroblasts against cytotoxic doses of tert-butylhydroperoxide and H2O2 PMID: 14741336
    15. new crystal form of human peroxiredoxin 5 is described at 2.0 A resolution; under initial reducing conditions, one chain remains oxidized and forms an homodimer with a symmetry-related one through intermolecular disulfide bonds between Cys47 and Cys151 PMID: 15046979
    16. plays a protective role in human tendon cells against oxidative stress by reducing apoptosis and maintaining collagen synthesis PMID: 15276323
    17. Human peroxiredoxin 5 is also a peroxynitrite reductase. PMID: 15280035
    18. nuclear PrxV associates with coilin-containing bodies suggesting possible interaction of this protein with transcription complexes PMID: 15304327
    19. The level of expression is directly correlated with the functional status of epithelial cells, being higher in multinodular goiters, and even more pronounced in hyperthyroid tissues, such as Graves' disease. PMID: 15785239
    20. mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability PMID: 15848167
    21. these findings suggest that PrxV is a multifunctional protein, which is essential for protection against apoptosis induced by anticancer drugs. PMID: 16781710
    22. Together, these results suggest that constitutively expressed PRDX5 gene plays an important role in protecting the genome against oxidation and may also be involved in the control of transcription of noncoding DNA. PMID: 16817890
    23. expression in white matter from normal human brain and MS patients PMID: 17623739
    24. we present new alternative splicing variants encoded specifically by human PRDX5 gene. The characterization of human PRDX5 gene revealed complexity of its regulation & high variability of sequences that might be associated with pathological situations. PMID: 17628720
    25. kinetic analysis of human peroxiredoxin 5 PMID: 17892856
    26. Peroxiredoxin V (PRXV) is an important antioxidant protein of lung epithelial cells. Its expression in the human lung increases in inflammation. PMID: 18219526
    27. report here three crystal forms in which this intramolecular disulfide bond is indeed observed. The structures are characterized by the expected local unfolding of the peroxidatic loop, but also by the unfolding of the resolving loop PMID: 18489898
    28. Ets regulates PRDX5 expression through their interaction with HGMB1 protein. PMID: 19016754
    29. crystal structure at 1.5 angstrom resolution PMID: 11518528

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  • 亞細胞定位：
    [Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic+peroxisomal]: Cytoplasm. Peroxisome matrix.
  • 蛋白家族：
    Peroxiredoxin family, Prx5 subfamily
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 9355

    OMIM: 606583

    KEGG: hsa:25824

    STRING: 9606.ENSP00000265462

    UniGene: Hs.502823



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