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  4. Recombinant Human Peroxiredoxin-5, mitochondrial (PRDX5)

Recombinant Human Peroxiredoxin-5, mitochondrial (PRDX5)

  • 中文名稱：
    人PRDX5重組蛋白
  • 貨號：
    CSB-YP018658HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PRDX5重組蛋白
  • 貨號：
    CSB-EP018658HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PRDX5重組蛋白
  • 貨號：
    CSB-EP018658HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PRDX5重組蛋白
  • 貨號：
    CSB-BP018658HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PRDX5重組蛋白
  • 貨號：
    CSB-MP018658HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PRDX5
  • Uniprot No.：
  • 別名：
    ACR1; Alu co repressor 1; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; B166; epididymis secretory protein Li 55; HEL-S-55; Liver tissue 2D-page spot 71B; mitochondrial; Peroxiredoxin 5; mitochondrial; Peroxiredoxin V; Peroxiredoxin-5; Peroxisomal antioxidant enzyme; PLP; PMP20; PRDX 5; PRDX5; PRDX5_HUMAN; PRDX6; Prx-V; PRXV; SBBI10; Thioredoxin peroxidase PMP20; Thioredoxin reductase; TPx type VI
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    53-214
  • 氨基酸序列
    MAPIKVGD AIPAVEVFEG EPGNKVNLAE LFKGKKGVLF GVPGAFTPGC SKTHLPGFVE QAEALKAKGV QVVACLSVND AFVTGEWGRA HKAEGKVRLL ADPTGAFGKE TDLLLDDSLV SIFGNRRLKR FSMVVQDGIV KALNVEPDGT GLTCSLAPNI ISQL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
  • 基因功能參考文獻：
    1. High PRX5 expression is associated with gastric cancer. PMID: 28535004
    2. Results found that Prx5 was increased in the cellular model of Alzheimer's disease (AD) and, identify a role for Prx5 as an upregulator of Cdk5 activation via reactive oxygen species-mediated Ca2+-mediated calpain activation. PMID: 28358580
    3. The PRX5 can be used as a predictive biomarker and serves as a putative therapeutic target for the development of clinical treatments for human CRC. PMID: 28431931
    4. peroxisomal PRDX5 protects oligodendrocytes against peroxisomal and mitochondrial oxidative stress. PMID: 25772011
    5. show here how the ligand-observed saturation transfer difference (STD) experiment and the PRDX5 protein-observed 15N-HSQC experiment, two popular NMR screening experiments, can be used to compare the binding modes of analogous fragments PMID: 25025339
    6. PRX5 is either consumed or its production is impaired in severe stroke PMID: 24385276
    7. This study demonistrated that overexpression of mitochondrial PRDX5 protects SH-SY5Y cells against the ROS/RNS-dependent neuronal death induced by MPP+. PMID: 23216451
    8. The promoter region critical for Prx5 gene regulation to which the novel negative transcription regulator, GATA1 binds in human breast cancer cell lines. PMID: 22020876
    9. basal expression of the human PRDX5 gene is regulated by GABP PMID: 20937353
    10. analysis of fragment molecules that bind the human peroxiredoxin 5 active site PMID: 20305821
    11. Glutaredoxin-dependent peroxiredoxin from poplar: protein-protein interaction and catalytic mechanism PMID: 11832487
    12. the expression of peroxiredoxin 5 is upregulated in osteoarthritis PMID: 12417342
    13. multiple subcellular targeting of peroxiredoxin 5 in mammalian cells can be implicated in antioxidant protective mechanisms under nonpathological conditions PMID: 14732291
    14. Transfection of PRXVI protects immortalized human WI-38 and murine NIH3T3 fibroblasts against cytotoxic doses of tert-butylhydroperoxide and H2O2 PMID: 14741336
    15. new crystal form of human peroxiredoxin 5 is described at 2.0 A resolution; under initial reducing conditions, one chain remains oxidized and forms an homodimer with a symmetry-related one through intermolecular disulfide bonds between Cys47 and Cys151 PMID: 15046979
    16. plays a protective role in human tendon cells against oxidative stress by reducing apoptosis and maintaining collagen synthesis PMID: 15276323
    17. Human peroxiredoxin 5 is also a peroxynitrite reductase. PMID: 15280035
    18. nuclear PrxV associates with coilin-containing bodies suggesting possible interaction of this protein with transcription complexes PMID: 15304327
    19. The level of expression is directly correlated with the functional status of epithelial cells, being higher in multinodular goiters, and even more pronounced in hyperthyroid tissues, such as Graves' disease. PMID: 15785239
    20. mitochondrial peroxiredoxin 5 may play an important role in mitochondrial genome stability PMID: 15848167
    21. these findings suggest that PrxV is a multifunctional protein, which is essential for protection against apoptosis induced by anticancer drugs. PMID: 16781710
    22. Together, these results suggest that constitutively expressed PRDX5 gene plays an important role in protecting the genome against oxidation and may also be involved in the control of transcription of noncoding DNA. PMID: 16817890
    23. expression in white matter from normal human brain and MS patients PMID: 17623739
    24. we present new alternative splicing variants encoded specifically by human PRDX5 gene. The characterization of human PRDX5 gene revealed complexity of its regulation & high variability of sequences that might be associated with pathological situations. PMID: 17628720
    25. kinetic analysis of human peroxiredoxin 5 PMID: 17892856
    26. Peroxiredoxin V (PRXV) is an important antioxidant protein of lung epithelial cells. Its expression in the human lung increases in inflammation. PMID: 18219526
    27. report here three crystal forms in which this intramolecular disulfide bond is indeed observed. The structures are characterized by the expected local unfolding of the peroxidatic loop, but also by the unfolding of the resolving loop PMID: 18489898
    28. Ets regulates PRDX5 expression through their interaction with HGMB1 protein. PMID: 19016754
    29. crystal structure at 1.5 angstrom resolution PMID: 11518528

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  • 亞細胞定位：
    [Isoform Mitochondrial]: Mitochondrion.; [Isoform Cytoplasmic+peroxisomal]: Cytoplasm. Peroxisome matrix.
  • 蛋白家族：
    Peroxiredoxin family, Prx5 subfamily
  • 組織特異性：
    Widely expressed.
  • 數據庫鏈接：

    HGNC: 9355

    OMIM: 606583

    KEGG: hsa:25824

    STRING: 9606.ENSP00000265462

    UniGene: Hs.502823



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