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  4. NAIP Recombinant Monoclonal Antibody

NAIP Recombinant Monoclonal Antibody

  • 中文名稱：
    NAIP重組抗體
  • 貨號：
    CSB-RA579492A0HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA579492A0HU diluted at 1:80 and staining in paraffin-embedded human placenta tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.48% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA579492A0HU重組單克隆抗體是針對NAIP蛋白研發的高特異性科研試劑。NAIP（神經元凋亡抑制蛋白）作為凋亡抑制蛋白家族成員，參與調控細胞凋亡過程及固有免疫應答，其功能異常與感染性疾病、神經退行性疾病等相關。本抗體采用重組技術制備，經ELISA和免疫組化（IHC）雙重平臺驗證，在IHC應用中展現出清晰的亞細胞定位能力，推薦使用稀釋比例為1:50-1:200，能有效識別石蠟切片等樣本中的天然構象靶蛋白。其高親和力特性確保在低豐度蛋白檢測中仍保持優異信噪比，適用于探索NAIP在細胞死亡調控、病原體識別通路中的分子機制研究，或用于肌萎縮側索硬化癥（ALS）等疾病模型的蛋白表達分析。該抗體具有嚴格的批次間一致性，可為免疫組織化學染色、蛋白質互作研究及信號通路分析提供可靠工具，滿足基礎科研中對蛋白表達與定位的精準檢測需求。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Baculoviral IAP repeat-containing protein 1 (Neuronal apoptosis inhibitory protein), NAIP, BIRC1
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human NAIP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    13E6
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.; Acts as a sensor component of the NLRC4 inflammasome that specifically recognizes and binds needle protein CprI from pathogenic bacteria C.violaceum. Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis. The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria such as C.violaceum and L.pneumophila.
  • 基因功能參考文獻：
    1. Our present report implies that NAIP will have broad implications for ALS symptoms as a risk factor and a promising prognostic biomarker. PMID: 29311650
    2. Data document a previously unknown localization of NAIP along the entire cytokinetic process whose dynamics exhibits a distinct behavior. PMID: 28059125
    3. NAIP expression is most abundant in M2 macrophages, while cIAP1 and cIAP2 show an inverse pattern of expression in polarized cells, cIAP2 is preferentially expressed in M1-macrophages and cIAP1 in M2-macrophages. IAP antagonist treatment of resting M0 macrophages preceding polarization stimulation, induced upregulation of NAIP in M2 and downregulation of cIAP1 in M1 and M2 but an induction of cIAP2 in M1 macrophages. PMID: 29518103
    4. Deletion in NAIP gene is associated with spinal muscular atrophy. PMID: 27754957
    5. NAIP and survivin expressions were significantly reduced following varicocele induction when compared to sham animals whereas PDRN-treated rats showed an increase in NAIP and survivin levels. PMID: 26347229
    6. The copy numbers and gene structures of NAIP genes were different in Chinese spinal muscular atrophy patients and healthy controls PMID: 25888055
    7. results revealed that SMN2 and NAIP copy numbers significantly influenced the age at onset, risk of death, and life expectancy in the spinal muscular atrophy patients and that the effect of SMN2 was more significant PMID: 25330799
    8. human Naip functions to activate the inflammasome in response to flagellin, similar to murine Naip5/6. PMID: 26109648
    9. Modulation of chemotherapeutic drug resistance in neuroblastoma SK-N-AS cells by the neural apoptosis inhibitory protein and miR-520f. PMID: 25137037
    10. Copy number variations of SMN2 and NAIP genes in patients are related to spinal muscular atrophy clinical types (P < 0.05). PMID: 24711022
    11. /NAIP1 and NAIP2/5 formed a large oligomeric complex with NLRC4 in the presence of corresponding bacterial ligands, and could support reconstitution of the NLRC4 inflammasome in a ligand-specific manner. PMID: 23940371
    12. identified an intronic region of the NAIP gene responding to TEAD1/YAP activity, suggesting that regulation of NAIP by TEAD1/YAP is at the transcriptional level PMID: 23994529
    13. the NAIP5-NLRC4 inflammasome is induced by direct interactions with conserved N- and C-terminal regions of flagellin PMID: 23012363
    14. NAIPFull gene duplication might have been evolutionary maintained, or even selected for, because it may confer an advantage to the host against flagellated bacteria PMID: 22067212
    15. There is a close relationship between SMN2, NAIP and H4F5 gene copy number and spinal muscular atrophy disease severity PMID: 21821450
    16. NOD domain is essential for effective inhibition of procaspase-9 and procaspase-3 cleavage by the NAIP protein in apoptosis. PMID: 21371431
    17. an inhibitor of procaspase-9 preventing apoptosis at the initiation stage PMID: 20171302
    18. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration PMID: 20044205
    19. Results provide the first structures of BIR domains from human NAIP and cIAP2. PMID: 19923725
    20. NAIP gene deletion was higher in type I spinal muscular atrophy than in type U or V. In type I patients lacking the NAIP gene, deterioration in their respiratory function is more rapid than in those type I patients retaining the NAIP gene. PMID: 11912351
    21. NAIP-deltaEx10-11: a novel splice variant of the apoptosis inhibitor NAIP is differently expressed in drug-sensitive and multidrug-resistant HL60 leukemia cells. NAIP transcripts might be involved in tumor resistance to chemotherapeutic agents. PMID: 12127562
    22. NAIP:Structural requirements for binding hippocalcin and effects on survival of sympathetic neurons. PMID: 12445469
    23. NAIP does not interact with Smac and requires ATP to bind caspase-9 PMID: 15280366
    24. Alterations in C/CAAT enhancer binding protein alpha and neuronal apoptosis inhibitory protein expression occurred in human adipose stromal-vascular cells after weight loss PMID: 15340105
    25. Multiple, domesticated long terminal repeats (LTRs) of endogenous retroviral elements provide NAIP promoter function in human, mouse, and rat. PMID: 17222062
    26. a role for NAIP in increasing the survival of cells undergoing terminal differentiation as well as the possibility that the protein serves as an intestinal pathogen recognition protein was suggested PMID: 17510375
    27. 80% neuronal apoptosis inhibitory protein gene deletion in 5q-spinal muscular atrophy patients (91% spinal muscular atrophy-I, 50% spinal muscular atrophy-II and -III), and in 5% (two of forty) of spinal muscular atrophy parents, was found. PMID: 17903057
    28. While there was no evidence of NAIP expression in the normal breast tissue, NAIP was expressed in all breast cancer samples. PMID: 17923748
    29. May be a modifying factor for disease severity of spinal muscular atrophy. PMID: 17932457
    30. The present study is the first one giving detailed information on SMN and NAIP deletion rates in Iranian SMA patients. PMID: 18071605
    31. Data show elevated expression of NAIP in peripheral mononuclear cells from children with Fabry disease. PMID: 18339188
    32. hNAIP and hIpaf mediate innate intracellular defense against flagellated Legionella in human cells. PMID: 18453601
    33. The presence of one NAIP copy, that is, heterozygous NAIP deletion, was common in Vietnamese SMA, regardless of clinical phenotype. PMID: 18533950
    34. HIAP-1 and HIAP-2 mRNA levels were elevated in resting T cells while NAIP mRNA was increased in whole blood in multiple sclerosis PMID: 18566024
    35. in glioma & glioblastoma multiforme, selective upregulation of miRNA-221 & down-regulation of a miRNA-221 mRNA target encoding BIRC1 were observed; expression of BIRC5 & caspase-3 were found to be significantly up-regulated, particularly in stage IV GBM PMID: 18759060
    36. Data show that NAIP deletion predicts disease severity in spinal muscular atrophy. PMID: 18842367
    37. Among the SMA Type I patients, 43% showed deletions of SMN1 and NAIP. PMID: 18974562
    38. findings of homozygous deletions of exon 7 and/or exon 8 of SMN1 gene confirmed the diagnosis of SMA, and suggested that the deletion of SMN1 exon 7 is a major cause of SMA in southern Chinese children. PMID: 19198020
    39. higher number of SMN2 copies makes the clinical symptoms more benign, and the NAIP gene deletion is associated with a more severe phenotype PMID: 19287802
    40. a novel NAIP isoform derives from intragenic Alu SINE promoters PMID: 19488400

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  • 組織特異性：
    Expressed in motor neurons, but not in sensory neurons. Found in liver and placenta, and to a lesser extent in spinal cord.
  • 數據庫鏈接：

    HGNC: 7634

    OMIM: 600355

    KEGG: hsa:4671

    STRING: 9606.ENSP00000428657

    UniGene: Hs.646951



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