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  4. LYVE1 Recombinant Monoclonal Antibody

LYVE1 Recombinant Monoclonal Antibody

  • 中文名稱：
    LYVE1重組抗體
  • 貨號：
    CSB-RA949150A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Immunofluorescence staining of HepG2 with CSB-RA949150A0HU at 1:25, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 505-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing HepG2 cells surface stained with CSB-RA949150A0HU (red line) at 1:50. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated Goat Anti-rabbit IgG(H+L) at 1:200 dilution for 35min at 4℃.Control antibody (green line) was rabbit IgG (1μg/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA949150A0HU LYVE1重組單克隆抗體是針對淋巴管內皮透明質酸受體1（LYVE1）研發的高特異性檢測工具。LYVE1作為淋巴管內皮標志物，在調控透明質酸代謝、介導免疫細胞遷移及腫瘤淋巴轉移中發揮重要作用。本產品采用重組技術制備，經ELISA、免疫熒光（IF）和流式細胞術（FC）嚴格驗證，在IF實驗中推薦1:50-1:200稀釋度可清晰顯示淋巴管內皮細胞的特異性信號定位，FC分析中同等稀釋度可實現細胞表面抗原的高效檢測。該抗體具備優異的批次間穩定性與低交叉反應性，適用于腫瘤微環境中淋巴管生成研究、免疫細胞運輸機制解析以及發育生物學中淋巴系統形態學研究等科研領域，為探索LYVE1在生理及病理過程中的功能調控提供可靠工具。
  • Uniprot No.：
  • 基因名：
    LYVE1
  • 別名：
    Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor), LYVE1, CRSBP1 HAR XLKD1
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from Human LYVE1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    11C11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.
  • 基因功能參考文獻：
    1. LYVE1 was up-regulated in the malignant Middle Cerebral Artery Infarction. PMID: 28828208
    2. this study shows up-regulation of LYVE-1 expression in the fetal circulation of conducting and exchange villi of HIV-infected pre-eclamptics PMID: 27529307
    3. Dendritic cells (DCs) docked to the basolateral surface of lymphatic vessels and transited to the lumen through hyaluronan-mediated interactions with the lymph-specific endothelial receptor LYVE-1. Targeted deletion of the gene Lyve1, antibody blockade or depletion of the DC hyaluronan coat not only delayed lymphatic trafficking of dermal DCs but also blunted their capacity to prime CD8(+) T cell responses in LNs. PMID: 28504698
    4. These findings reveal binding is dependent not just on clustering but also on the biochemical properties of LYVE-1 homodimers. They also mark LYVE-1 as the first Link protein superfamily member requiring covalent homodimerization for function and suggest the interchain disulfide acts as a redox switch in vivo. PMID: 27733683
    5. LYVE1 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    6. Immunostaining analyses in psoriasis skin lesions suggested that the ectodomain shedding of LYVE-1 occurred in lymphatic vessels undergoing chronic inflammation. These results indicate that the ectodomain shedding of LYVE-1 might be involved in promoting pathological lymphangiogenesis. PMID: 26966180
    7. These results demonstrate the prerequisite of a critical LYVE-1 threshold density and show that hyaluronan binding may be elicited in lymphatic endothelium by surface clustering with divalent LYVE-1 mAbs. PMID: 26823460
    8. We have established a novel, three-protein biomarker panel that is able to detect patients with early-stage pancreatic cancer in urine specimens:LYVE-1, REG1A, and TFF1 were selected as candidate biomarkers PMID: 26240291
    9. Data (including data from studies in knockout mice) suggest LYVE1 mediates adhesion of group A Streptococci (GAS) to lymphatic vesicular endothelium via capsular hyaluronan; this appears to be critical factor for lymphatic trafficking of GAS in vivo. PMID: 26352587
    10. High expression of LYVE-1 is associated with atherosclerotic arteries. PMID: 25318003
    11. High LYVE expression is associated with visceral pleural invasion and lymphatic thromboembolism in non-small-cell lung cancer. PMID: 25141859
    12. Data indicate that detection of lymphatic vascular invasion (LVI) can be optimized by specific D2-40 or LYVE-1 staining. PMID: 21974896
    13. High-low cell surface HA content of tumor cells through the interaction with LYVE-1 leads to adhesion differences. PMID: 23717428
    14. FGF2 binds to LYVE-1 with a higher affinity than any other known LYVE-1-binding molecules, such as hyaluronan or PDGF-BB. Glycosylation of LYVE-1 is important for FGF2 binding. PMID: 23264596
    15. CRSBP-1-associated fibrillar structures are identical to the ER network as evidenced by the co-localization of CRSBP-1 and BiP in these cells PMID: 22673514
    16. LYVE-1 may have value as predictor of outcome in neuroblastoma PMID: 22241180
    17. Significant correlation between LYVE-1 and Prox-1 expression was observed in non-small cell lung cancer. Expression was also correlated with lymph node metastasis. PMID: 21500548
    18. LYVE-1, VEGFR-3 and CD44 all play an important role in lymphangiogenesis, invasion and metastasis PMID: 21912471
    19. these data support interdependent roles for emmprin, LYVE-1 and BCRP in chemotherapeutic resistance for PEL PMID: 21660043
    20. Results suggest that LYVE-1 allows the adhesion of tumor cells through the interaction of HA on the tumor cell membrane with LYVE-1. PMID: 21291635
    21. Intratumoral lymph vessel density marked by LYVE-1 in laryngeal carcinoma was significantly correlated with tumor infiltration and metastasis. PMID: 17144490
    22. Data show that the density of LYVE-1/+ capillaries in skeletal muscle was observed to decrease significantly over the time course of the exercise intervention. PMID: 20863269
    23. findings indicated that LYVE-1 attenuation in sinusoidal endothelium was one of the manifestations of capillarization, and was associated with hepatic disease progression PMID: 19908110
    24. LYVE-1 indicates an increase of lymphangiogenesis in colorectal carcinoma. PMID: 19742347
    25. A study using specific markers of endothelium (CD31) and lymphatic endothelial cells (Lyve-1, Podoplanin) shows that not only angiogenesis but also lymphangiogenesis occurs within the nodule. PMID: 20011036
    26. new approach measuring lymphangiogenesis using LYVE-1, a novel, specific lymphatic marker in breast cancer tissue PMID: 11689016
    27. LYVE-1 is not exclusive to the lymph vessels PMID: 11719431
    28. LYVE-1 does not seem to be a reliable marker for proliferating infantile hemangiomas. PMID: 16424896
    29. findings indicate (1) the importance of LYVE-1, but not CD44, in regulation of HA metabolism in the maternal-fetal interface and fetal circulation, and (2) possible dual blood and lymphatic phenotypic characteristics in fetal endothelium PMID: 16569201
    30. Molecular data based on gene transcriptional profiles of a 3-gene set (GPC3, LYVE1, and survivin) allow a reliable diagnosis of early hepatocellular carcinoma. PMID: 17087938
    31. analysis of inflammation-induced uptake and degradation of the lymphatic endothelial hyaluronan receptor LYVE-1 PMID: 17884820
    32. DC-sign+ CD163+ macrophages expressing hyaluronan receptor LYVE-1 are located within chorion villi of the placenta. PMID: 18078989
    33. Presence of LYVE-1 in pancreatic islets and in some pancreatic endocrine tumors may suggest structure-function relationship of LYVE-1/lymphatic vessel in hormone synthesis and secretion. PMID: 18090227
    34. LYVE-1 immunohistochemistry appeared to be a useful method for detecting lymphatics invaded by cancer cells, and detailed examination of the submucosa around the tumor may be important for predicting LN metastasis. PMID: 18181096
    35. LYVE-1 expression and the lymphatic density of the muscularis propria are significantly greater than those of other layers of urothelium, including the epithelium, lamina propria, perivesical fat, and serosa PMID: 18342921
    36. LYVE-1 is expressed in a reticulum cell neoplasm in an axillary lymph node. This reticulum cell sarcoma is a lymphatic sinus lining cell sarcoma which might represent another subtype of reticulum cell sarcomas. PMID: 18386053
    37. The normal adult human choroid does not contain typical lymph vessels, but is endowed with a significant number of LYVE-1 positive macrophages. PMID: 18689706
    38. complexity in the regulation of LYVE-1 function and raise the possibility that this receptor, like CD44, may become active after appropriate unmasking in vivo. PMID: 19033446
    39. LYVE-1 immunostaining in some gastrointestinal carcinoids may support a structure-function relationship of lymphatic vessels/hyaluronan receptor for modulating synthesis and secretion of hormones and amines by carcinoid tumour cells. PMID: 19291537
    40. CRSBP-1 exhibits dual ligand (CRS-containing growth regulators (v-sis gene product and insulin-like growth factor binding protein-3, IGFBP-3) and hyaluronic acid) binding activity and plays a role in autocrine regulation of cell growth. PMID: 12912978

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  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Note=Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand-dependent internalization and recycling at the cell surface.
  • 組織特異性：
    Mainly expressed in endothelial cells lining lymphatic vessels.
  • 數據庫鏈接：

    HGNC: 14687

    OMIM: 605702

    KEGG: hsa:10894

    STRING: 9606.ENSP00000256178

    UniGene: Hs.655332



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