在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. IL13RA1 Recombinant Monoclonal Antibody

IL13RA1 Recombinant Monoclonal Antibody

  • 中文名稱：
    IL13RA1重組抗體
  • 貨號：
    CSB-RA011591MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA011591MA1HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA011591MA1HU IL13RA1重組單克隆抗體是針對人源白介素13受體α1亞基（IL13RA1）開發的高特異性科研工具。該抗體靶向IL13RA1蛋白，該分子作為IL-13信號通路的關鍵組分，廣泛參與Th2型免疫應答調控，并在過敏性疾病、組織纖維化及腫瘤免疫微環境調節中發揮重要作用。經嚴格驗證，本產品在ELISA實驗中展現出優異的抗原結合能力，同時適用于石蠟包埋組織切片的免疫組化檢測，推薦使用濃度為1:50至1:200，能清晰顯示目標蛋白在組織中的定位分布。其重組單克隆特性確保了批次間的高度一致性，適用于免疫機制研究、疾病模型構建及病理樣本分析等科研場景，為探索IL13RA1在炎癥相關疾病和腫瘤生物學中的功能提供了可靠工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    IL13RA1 Recombinant Monoclonal Antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human IL13RA1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10E7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
  • 基因功能參考文獻：
    1. High IL13RA1 expression is associated with Invasive breast Cancer. PMID: 28634667
    2. in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID: 28528324
    3. sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID: 28874358
    4. IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID: 26153764
    5. required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID: 25766112
    6. Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID: 25896327
    7. miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID: 25529447
    8. MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID: 23965966
    9. In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID: 23169588
    10. These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID: 21294892
    11. The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID: 21425907
    12. IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID: 21236478
    13. Mutation and functional analysis in human malignant glioma cells PMID: 11939409
    14. IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID: 12522691
    15. Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID: 12594065
    16. Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID: 14527737
    17. Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID: 16918506
    18. IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID: 17006604
    19. the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID: 17392323
    20. concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID: 19654941

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 組織特異性：
    Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
  • 數據庫鏈接：

    HGNC: 5974

    OMIM: 300119

    KEGG: hsa:3597

    STRING: 9606.ENSP00000360730

    UniGene: Hs.496646



主站蜘蛛池模板： 国产99久久久国产无需播放器| 久久www免费人成一看片 | 久久发布国产伦子伦精品| 亚洲精品国产成人99久久6| 国产精品黄页免费高清在线观看 | 一区二区三区鲁丝不卡麻豆| 日韩精品无码不卡无码| 国产精品喷浆| 亚洲综合无码一区二区| 啦啦啦中文在线观看日本| 久久午夜夜伦鲁鲁片免费无码影视| 97久章草在线视频播放| 中文字幕无线观看不卡网站| 欧美亚洲精品一区二区 | 无码一区二区三区免费| 国产午夜无码片免费| 夜晚成人18禁区导航网站| 国产精品区av| 国产成人精品午夜福利| 性欧美疯狂xxxxbbbb| 亚洲乱色伦图片区小说| 青青草在在观免费福利线观看| 亚洲区小说区图片区qvod| 亚洲色成人www永久网站| 在线综合亚洲欧美日韩| 国产成 人 综合 亚洲| 久久精品国产日本波多野结衣| 国产又黄又猛又粗又爽的a片动漫 成年女性特黄午夜视频免费看 | 亚洲精品中文字幕乱码4区| 日日碰狠狠躁久久躁| 国产男女免费完整视频| 99视频有精品视频高清| 国产无套粉嫩白浆在线观看 | 国产精品综合色区在线观看| 97se亚洲国产综合自在线观看| 久久精品国产99久久香蕉| ww欧日韩视频高清在线| 久久精品99国产精品日本| аⅴ天堂中文在线网| 国产极品美女到高潮无套| 无码免费中文字幕视频|