在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. IL13RA1 Recombinant Monoclonal Antibody

IL13RA1 Recombinant Monoclonal Antibody

  • 中文名稱：
    IL13RA1重組抗體
  • 貨號：
    CSB-RA011591MA1HU
  • 規格：
    ￥1320
  • 圖片：
    • IHC image of CSB-RA011591MA1HU diluted at 1:200 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品描述：
    CSB-RA011591MA1HU IL13RA1重組單克隆抗體是針對人源白介素13受體α1亞基（IL13RA1）開發的高特異性科研工具。該抗體靶向IL13RA1蛋白，該分子作為IL-13信號通路的關鍵組分，廣泛參與Th2型免疫應答調控，并在過敏性疾病、組織纖維化及腫瘤免疫微環境調節中發揮重要作用。經嚴格驗證，本產品在ELISA實驗中展現出優異的抗原結合能力，同時適用于石蠟包埋組織切片的免疫組化檢測，推薦使用濃度為1:50至1:200，能清晰顯示目標蛋白在組織中的定位分布。其重組單克隆特性確保了批次間的高度一致性，適用于免疫機制研究、疾病模型構建及病理樣本分析等科研場景，為探索IL13RA1在炎癥相關疾病和腫瘤生物學中的功能提供了可靠工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    IL13RA1 Recombinant Monoclonal Antibody
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human IL13RA1 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    hIgG1
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    10E7
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity.
  • 基因功能參考文獻：
    1. High IL13RA1 expression is associated with Invasive breast Cancer. PMID: 28634667
    2. in humans and mice indicate, for the first time, a role of interleukin-13 receptor alpha1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease. PMID: 28528324
    3. sIL13ralpha1 as a circulating human protein with an unexpected role in glucose metabolism. PMID: 28874358
    4. IL-13Ralpha1 has a protective role in bleomycin-induced pulmonary injury and repair. PMID: 26153764
    5. required for induction of the alternative macrophage activation pathway by IL-13 but not by IL-4 PMID: 25766112
    6. Results identified FAM120A in the IL13/IL13Ralpha2 signaling pathway as a key mediator of invasion and liver metastasis in colon cancer. PMID: 25896327
    7. miR-143 regulation of IL-13-induced inflammatory cytokine and mucus production in nasal epithelial cells from allergic rhinitis patients probably partly depends on inhibition of IL13Ralpha1. PMID: 25529447
    8. MiR-143 may be associated with allergic reaction in human mast cells via downregulation of IL13RA1. PMID: 23965966
    9. In humans, IL-13Ralpha1 lies within the PARK12 locus of susceptibility to Parkinson's disease and may have a role in the pathogenesis of this neurodegenerative disease. PMID: 23169588
    10. These results indicate that an inherited polymorphism of the IL-4R controls the ability of the human immune system to regulate the magnitude of IL-17 production PMID: 21294892
    11. The IL-13R A(1) +1398 A/G polymorphism does not contribute to asthma or allergic rhinitis susceptibility. PMID: 21425907
    12. IL-13Ralpha1 is expressed on human CD4(+) T(H)17 cells PMID: 21236478
    13. Mutation and functional analysis in human malignant glioma cells PMID: 11939409
    14. IL4RA and STAT6 are candidate genes for atopic disorders. 26 single-nucleotide polymorphisms (SNPs)and simple repeats are being reported spanning a total of 147kb in IL4RA and STAT6 genes of the Indian population PMID: 12522691
    15. Allele frequency of IL13RA1 polymorphism was not associated with rapid decline of lung function in smokers. PMID: 12594065
    16. Overexpression of IL-13Ralpha1 may play some role in pathogenesis of chronic stage of atopic dermatitis or psoriasis. PMID: 14527737
    17. Bronchial submucosal mast cell IL-13 receptor alpha 1 expression is higher in asthmatics than normal controls. PMID: 16918506
    18. IL-13Ralpha1 polymorphism was associated with higher total IgE in children with atopic asthma PMID: 17006604
    19. the IL13RA1 subunit gene -281T>G and 1365A>G polymorphisms do not contribute to asthma susceptibility or severity, although the IL13RA1 subunit gene locus might be involved in the control of immunoglobulin E production PMID: 17392323
    20. concomitant expression of IL-13Ralpha1 and IL-13Ralpha2 may be associated with the pathogenesis of idiopathic interstitial pneumonia. PMID: 19654941

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Type I cytokine receptor family, Type 5 subfamily
  • 組織特異性：
    Ubiquitous. Highest levels in heart, liver, skeletal muscle and ovary; lowest levels in brain, lung and kidney. Also found in B-cells, T-cells and endothelial cells.
  • 數據庫鏈接：

    HGNC: 5974

    OMIM: 300119

    KEGG: hsa:3597

    STRING: 9606.ENSP00000360730

    UniGene: Hs.496646



主站蜘蛛池模板： 久久久久99精品国产片| 国产精品成人观看视频| 精品无码国产自产在线观看水浒传 | 樱桃视频影视在线观看免费| 狠狠色噜噜狠狠狠8888米奇| 亚洲国产成人av片在线播放| 久久亚洲精品无码av宋| 国产网红女主播精品视频| 日本一本二本三区免费| 久久国产成人免费网站| 国产在线观看精品一区二区三区| 欧美精品黑人粗大免费| 国产精品va无码免费| 国精品人妻无码一区二区三区喝尿 | 国产精品乱码久久久久软件| 中文字幕一区二区三区四区五区| 国产精品vr专区| 永久免费的av在线电影网| 亚洲人成电影在线天堂色| 少妇粉嫩小泬白浆流出| 99精品国产兔费观看久久99| 国产精品96久久久久久av网址| 亚洲国产综合在线区尤物| 国产美女精品一区二区三区| 99久久精品精品6精品精品| 久久99国产精品二区| 最新亚洲人成无码网站| 国产精品无码久久av| 国产精品成人永久在线四虎| 2020久久天天躁狠狠躁夜夜| 久久无码专区国产精品| 玩弄少妇人妻| 熟女熟妇伦av网站| av在线播放日韩亚洲欧我不卡 | 日本大片免费观看视频| 日韩国产人妻一区二区三区| 成人免费视频一区二区| 一本天堂v无码亚洲道久久| а天堂中文最新版在线| 69精品丰满人妻无码视频a片| 国产综合精品久久丫|