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HMGCS2 Recombinant Monoclonal Antibody

  • 中文名稱：
    HMGCS2重組抗體
  • 貨號：
    CSB-RA693900A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: A549 whole cell lysate, Ntera-2 whole cell lysate
      All lanes: HMGCS2 antibody at 1:500
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 57, 53, 51 kDa
      Observed band size: 55 kDa
    • IHC image of CSB-RA693900A0HU diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
    • IHC image of CSB-RA693900A0HU diluted at 1:100 and staining in paraffin-embedded human appendix tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit polymer IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CSB-RA693900A0HU HMGCS2重組單克隆抗體是針對線粒體酶3-羥基-3-甲基戊二酰輔酶A合成酶2（HMGCS2）開發(fā)的高特異性科研工具。HMGCS2是酮體生成途徑中的限速酶，參與調(diào)控肝臟能量代謝穩(wěn)態(tài)，其表達異常與代謝性疾病、神經(jīng)系統(tǒng)疾病及腫瘤發(fā)生相關(guān)。本抗體經(jīng)ELISA、Western Blot（WB）和免疫組化（IHC）多平臺驗證，在WB實驗中呈現(xiàn)清晰單一目標條帶，推薦使用稀釋度為1:500-1:2000；IHC應(yīng)用顯示優(yōu)異的組織定位能力，建議稀釋比為1:50-1:200。其重組單克隆特性確保了批次間的高度一致性，適用于檢測人類樣本中HMGCS2的蛋白表達水平及亞細胞定位分析。該產(chǎn)品可廣泛應(yīng)用于代謝重編程機制研究、肝臟或腎臟疾病模型中的能量代謝評估，以及腫瘤微環(huán)境與細胞代謝互作等基礎(chǔ)研究領(lǐng)域，為探索HMGCS2在生理病理過程中的分子調(diào)控網(wǎng)絡(luò)提供可靠檢測工具。
  • Uniprot No.：
  • 基因名：
  • 別名：
    Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase), HMGCS2
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    A synthesized peptide derived from human HMGCS2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    19C11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in 10mM phosphate buffered saline , pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
  • 基因功能參考文獻：
    1. several nutrients as well as specific nutritional related hormonal conditions are able to affect significantly HMGCS2 gene expression. PMID: 28888048
    2. miR-107-mediated decrease of HMGCS2 indicates poor outcomes and promotes cell migration in hepatocellular carcinoma PMID: 28867541
    3. this studies demonstrate that HMGCS2 functions as a transcriptional factor that binds to peroxisome proliferator-activated receptor alpha (PPARalpha), resulting in Src expression and activation in a metabolically independent manner PMID: 27816970
    4. HMGCS2 shares with ketone bodies common features in autophagic clearance of APP, suggesting that ketone bodies play an important role in HMGCS2 regulation of the autophagy. PMID: 28320515
    5. High expression of either HSD17B2 or HMGCS2 predicted poor susceptibility of rectal cancer to preoperative chemoradiotherapy. PMID: 25929810
    6. FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast PMID: 25389781
    7. In Fe-S cluster-deficient muscles, results show a dramatic up-regulation of the ketogenic enzyme HMGCS2 and the secreted protein FGF21 (fibroblast growth factor 21). PMID: 23943793
    8. Human HMGCS2 regulates mitochondrial fatty acid oxidation and FGF21 expression PMID: 21502324
    9. Ketogenesis is an undesirable metabolic characteristic of the proliferating cell, which is down-regulated through c-Myc-mediated repression of the key metabolic gene HMGCS2. PMID: 16940161

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  • 相關(guān)疾病：
    3-hydroxy-3-methylglutaryl-CoA synthase-2 deficiency (HMGCS2D)
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    HMG-CoA synthase family
  • 組織特異性：
    Expression in liver is 200-fold higher than in any other tissue. Low expression in colon, kidney, testis, and pancreas. Very low expression in heart and skeletal muscle. Not detected in brain.; [Isoform 3]: Highest expression detected in heart and skeleta
  • 數(shù)據(jù)庫鏈接：

    HGNC: 5008

    OMIM: 600234

    KEGG: hsa:3158

    STRING: 9606.ENSP00000358414

    UniGene: Hs.59889



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