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  4. EIF3B Recombinant Monoclonal Antibody

EIF3B Recombinant Monoclonal Antibody

  • 中文名稱：
    EIF3B Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA553176A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of EIF3B expression in HepG2 cells using EIF3B antibody. Green, isotype control; red, EIF3B.
    • Western blotting analysis using EIF3B antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with EIF3B antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    EIF3B
  • 別名：
    EIF3B; Eukaryotic Translation Initiation Factor 3 Subunit B; EIF3S9; PRT1; Eukaryotic Translation Initiation Factor 3, Subunit 9 Eta, 116kDa; Eukaryotic Translation Initiation Factor 3 Subunit 9; Protein Synthesis 1; Prt1 Homolog; Eukaryotic Translation Initiation Factor 3, Subunit 9 (Eta, 116kD); Eukaryotic Translation Initiation Factor 3, Subunit B; EIF3-P110; EIF3-P116; EIF-3-Eta; EIF3 P110; EIF3 P116; EIF3-ETA; EIF3b; HPrt1
  • 反應(yīng)種屬：
    Human, Mouse, Rat
  • 免疫原：
    Recombinant Human EIF3B protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    8D2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2.
  • 基因功能參考文獻(xiàn)：
    1. Study demonstrated that EIF3B expression was up-regulated in esophageal squamous cell carcinoma cells and negatively correlated with the prognosis of patients. PMID: 27270324
    2. Novel RNA-binding protein P311 binds eIF3b to promote translation of TGF-beta1, TGF-beta2, TGF-beta3. PMID: 25336651
    3. Report EIF3B binding within the IRES domain V of the coxsackie virus B3 mutant strain. PMID: 24063684
    4. eIF3b expression relates to human bladder and prostate cancer prognosis, is required for tumor growth, and thus a candidate therapeutic target. PMID: 23575475
    5. EIF3B promotes the proliferation of U87 human glioblastoma cells and may play an important role in human glioblastoma development. PMID: 22234522
    6. Yeast eIF3b exhibits RNA binding activity but huamn eIF3b doesn't. PMID: 20862284
    7. a conserved tryptophan residue in the human eIF3j N-terminal acidic motif (NTA) is held in the helix alpha1 and loop 5 hydrophobic pocket of the human eIF3b RNA recognition motif (RRM) PMID: 20060839
    8. structural analysis of the eIF3b RNA recognition motif and its interaction with eIF3j PMID: 17190833

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  • 亞細(xì)胞定位：
    Cytoplasm.
  • 蛋白家族：
    EIF-3 subunit B family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 3280

    OMIM: 603917

    KEGG: hsa:8662

    STRING: 9606.ENSP00000354125

    UniGene: Hs.371001



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