在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. DPF2 Recombinant Monoclonal Antibody

DPF2 Recombinant Monoclonal Antibody

  • 中文名稱：
    DPF2 Recombinant Monoclonal Antibody
  • 貨號：
    CSB-RA795437A0HU
  • 規格：
    ￥1320
  • 圖片：
    • Western Blot
      Positive WB detected in: Jurkat whole cell lysate(30μg), A431 whole cell lysate(30μg), K562 whole cell lysate(30μg)
      All lanes: DPF2 antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/40000 dilution
      Predicted band size: 44 kDa
      Observed band size: 44 kDa
      Exposure time：1min
    • Immunofluorescence staining of U-251MG cell with CSB-RA795437A0HU at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Overlay Peak curve showing jurkat cells stained with CSB-RA795437A0HU (red line) at 1:100. The cells were fixed in 4% formaldehyde and permeated by 0.2% TritonX-100 for?10min. Then 10% normal goat serum to block non-specific protein-protein interactions followed by the antibody (1ug/1*106cells) for 45min at 4℃. The secondary antibody used was FITC-conjugated goat anti-rabbit IgG (H+L) at 1/200 dilution for 35min at 4℃.Control antibody (green line) was Rabbit IgG (1ug/1*106cells) used under the same conditions. Acquisition of >10,000 events was performed.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    DPF2
  • 別名：
    Zinc finger protein ubi-d4 (Apoptosis response zinc finger protein) (BRG1-associated factor 45D) (BAF45D) (D4, zinc and double PHD fingers family 2) (Protein requiem), DPF2, BAF45D REQ UBID4
  • 反應種屬：
    Human
  • 免疫原：
    A synthesized peptide from human DPF2 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    3E2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IF, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:50-1:200
    FC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays an active role in transcriptional regulation by binding modified histones H3 and H4. Is a negative regulator of myeloid differentiation of hematopoietic progenitor cells. Might also have a role in the development and maturation of lymphoid cells. Involved in the regulation of non-canonical NF-kappa-B pathway.
  • 基因功能參考文獻：
    1. de novo variants in DPF2 cause Coffin-Siris syndrome and propose a dominant-negative mechanism of pathogenicity. PMID: 29429572
    2. Authors show that DPF2 interacts with the acetylated tails of both histones 3 and 4 via bipartite binding pockets on the DPF2 surface. Blocking these interactions through targeted mutagenesis of DPF2 abolishes its recruitment to target chromatin regions as well as its ability to prevent myeloid differentiation in vivo. PMID: 28533407
    3. Upon influenza virus infection, DPF2 dysregulated IFN-beta induction and expression of cytokines/chemokines and antiviral proteins. This study provides evidence that influenza virus utilizes DPF2 to escape host innate immunity. PMID: 28404846
    4. The demonstrate that the histone acetylation-binding double PHD finger (DPF) domains of human MOZ (also known as KAT6A) and DPF2 (also known as BAF45d) accommodate a wide range of histone lysine acylation with the strongest preference for propionylation (Kcr). PMID: 27775714
    5. the role of SMARCA4 and the two SWI/SNF subunits SMARCD2/BAF60B and DPF2/BAF45D in leukaemia, was investigated. PMID: 26571505
    6. DPF2 decreases monomeric and mono-ubiquitinated OCT4, assembles poly-ubiquitin chains on OCT4 mainly through Ub-K48 linkage PMID: 26417682
    7. crystal structure of the C2H2-type zinc finger domain of human DPF2 with a canonical C2H2 fold, which contains two beta strands and one alpha helix, was reported. PMID: 21888896
    8. found that targeting Requiem and Alg-2 did not result in extended culture viability, but resulted in an increase in maximum viable cell numbers and cumulative IVCD under fed-batch conditions PMID: 20571937

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Requiem/DPF family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 9964

    OMIM: 601671

    KEGG: hsa:5977

    STRING: 9606.ENSP00000436901

    UniGene: Hs.13495



主站蜘蛛池模板： 无码专区人妻系列日韩精品| 屁屁影院ccyy备用地址| 熟睡人妻被讨厌的公侵犯| 女人爽到高潮潮喷18禁网站| 国产精品久久自在自线不卡| 国产精品无码a∨麻豆| 亚洲国产av美女网站| 久久久欧美国产精品人妻噜噜 | 无码国产成人久久| 狠狠97人人婷婷五月| 人妻精品国产一区二区| 老汉色老汉首页a亚洲| 少妇人妻偷人精品无码视频新浪| 国产sm调教折磨视频| 直接观看黄网站免费视频| 日本老熟妇乱子伦视频| 国产午夜精品一区二区三区| 97精品一区二区视频在线观看| 大学生被内谢粉嫩无套| 久久天天躁夜夜躁狠狠躁| 欧美人与性囗牲恔配| 狠狠色丁香久久婷婷综合五月 | 狠狠躁日日躁夜夜躁2020| 欧美日韩一本无线码专区| 亚洲裸男gv网站| 亚洲精品成人无限看| 国产精品午夜福利麻豆| 亚洲精品偷拍影视在线观看| 99久久久无码国产精品6| 天天看片视频免费观看| 日本免费人成在线观看网站| 青春草在线视频观看| 亚洲综合在线另类色区奇米| 无码国产片观看| 无码爆乳护士让我爽| 午夜理论片yy44880影院| 亚洲精品久久久久久久久久久捆绑| 国产精品久久久久影院亚瑟| 动漫精品啪啪一区二区三区| 日产日韩亚洲欧美综合在线| 中日韩产精品1卡二卡三卡|