在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 重組抗體
  4. CLDN6/9 Recombinant Monoclonal Antibody

CLDN6/9 Recombinant Monoclonal Antibody

  • 中文名稱：
    CLDN6/9 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA005508MA3HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • The Binding Activity of Human CLDN6 with Anti-CLDN6-9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6 (CSB-MP005508HU(A4)) at 10 μg/mL can bind Anti-CLDN6-9 recombinant antibody. The EC50 is 1.189-1.618 ng/mL. The VLPs (CSB-MP3838) is negative control.
    • The Binding Activity of Human CLDN6 with Anti-CLDN6-9 recombinant antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CLDN6-9 (CSB-MP005511HU) at 10 μg/mL can bind Anti-CLDN6-9 recombinant antibody. The EC50 is 2.876-3.657 ng/mL. The VLPs (CSB-MP3838) is negative control.
    • Untransfected HEK-293T cells (green line) and transfected Human CLDN6 HEK-293T stable cells (red line) were stained with anti-CLDN6/9 antibody(CSB-RA005508MA3HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Mouse IgG Fc antibody and analyzed with flow cytometry.
    • Untransfected CHO-K1*106cells), washed and then followed by APC-conjugated anti-Mouse IgG Fc antibody and analyzed with flow cytometry.
    • Untransfected HEK-293T cells (green line) and transfected Human CLDN9 HEK-293T stable cells (red line) were stained with anti-CLDN6/9 antibody (CSB-RA005508MA3HU) (2μg/1*106cells), washed and then followed by APC-conjugated anti-Mouse IgG Fc antibody and analyzed with flow cytometry.
    • The Binding Activity of Mouse cldn6 with Anti-CLDN6/9 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Mouse cldn6(CSB-MP3347MO) at 5 μg/mL can bind Anti-CLDN6/9 recombinant antibody. The EC50 is 7.349-12.12 ng/mL.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLDN6/9
  • 別名：
    Claudin-6 antibody; Claudin6 antibody; CLD6_HUMAN antibody; CLDN 6 antibody; CLDN6 antibody; OTTHUMP00000159248 antibody; Skullin 2 antibody; Skullin antibody; UNQ757/PRO1488 antibody
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human CLDN6/9 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    mFc2a
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    9E2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
  • 基因功能參考文獻(xiàn)：
    1. Antibodies recognizing native CLDN6 as displayed on cell surfaces and mediating complement-dependent cytotoxicity were elicited in vaccinated animals. The data suggest applications of CLDN6 displaying Virus-like particles in cancer immunotherapy. PMID: 29131519
    2. these results suggest that Helicobacter pylori lipopolysaccharide induces TLR2 expression in the gastric adenocarcinoma cells, and that the longer the exposure to lipopolysaccharide, the greater the expression of TLR2 in the cell membrane; consequently the expression of claudin-4, -6, -7 and -9 also increases PMID: 29031421
    3. Study provides evidence that high expression of CLDN6 confers chemoresistance on breast cancer which is mediated by GSTP1, the activity of which is regulated by p53. PMID: 29116019
    4. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. PMID: 29159771
    5. we demonstrated that the downregulation of CLDN6 is regulated through promoter methylation by DNMT1, which depends on the SMAD2 pathway, and that CLDN6 is a key regulator in the SMAD2/DNMT1/CLDN6 pathway to inhibit EMT, migration and invasion of breast cancer cells PMID: 28867761
    6. In conclusion, this information from bioinformatics analysis will help future attempts to better understand CLDN6 regulation and functions. PMID: 28656265
    7. high expression of CLDN 6 was observed in approx. 65% of the myxofibrosarcomas, whereas the benign soft tissue tumors did not show a high expression of CLDN 6. The expression of CLDN 6 in the myxofibrosarcomas was significantly higher than those of other tumor specimens. Among the myxofibrosarcomas, the high expression of CLDN 6 was correlated with high FNCLCC grades and high AJCC stages. PMID: 28476380
    8. Results show that DNA methylation down-regulates CLDN6 expression through MeCP2 binding to the CLDN6 promoter, deacetylating H3 and H4, and altering chromatin structure, consequently promoting migratory and invasive phenotype in breast cancer cells. PMID: 27461117
    9. Cldn6 was decreased in alveolar type II-like epithelial cells (A549) and primary small airway epithelial cells when exposed to cigarette smoke ext PMID: 27982694
    10. suggest that claudin-6 induces MMP-2 activation through claudin-1 membrane expression PMID: 27914788
    11. Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry. PMID: 26561856
    12. The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues. PMID: 26191261
    13. High levels of CLDN6 are associated with non-small-cell lung cancer. PMID: 24710653
    14. The expression of claudin-6 was down regulated in gastric cancer tissue. PMID: 23919729
    15. Only some hepatitis C virus strains efficiently use CLDN6 for infection. PMID: 23775920
    16. This work provides a proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture. PMID: 23778593
    17. Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9. PMID: 23864633
    18. ASK1 signal may play a positive role in the inhibitory effect of claudin-6 in breast cancer. PMID: 22925655
    19. Our results show that claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas PMID: 22455563
    20. CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in a variety of other pediatric CNS and soft tissue tumors. PMID: 21989342
    21. 17beta-E2 might regulate the expression of claudin-6 and inhibit the proliferation and migration of MCF-7 cells. PMID: 20388399
    22. Increased expression of claudin-6, claudin-7, or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line. PMID: 20874001
    23. CLDN6 may be a useful positive marker to help further identify atypical teratoid/rhabdoid tumors for diagnostic and treatment purposes PMID: 19220299
    24. Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis PMID: 19960275
    25. The up-regulation of claudin-6 expression in MCF-7 breast cancer cells suppresses their malignant phenotypes with a correlation with the restoration of tight junction integrity. PMID: 20367941
    26. claudin-6, downregulates the malignant phenotype of breast carcinoma. PMID: 20215972
    27. Claudin 6 was not found in epithelioid glioblastomas or rhabdoid glioblastomas. PMID: 20118769
    28. CLDN6 and CLDN9, but not CLDN1, are expressed in peripheral blood mononuclear cells, an additional site of HCV replication. PMID: 17804490
    29. claudin-6 and claudin-9 expressed in CD81+ cells also enable the entry of HCV pseudoparticles derived from six of the major genotypes. PMID: 18234789
    30. CLDN6, clustered with CLDN9 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2048

    OMIM: 615798

    KEGG: hsa:9074

    STRING: 9606.ENSP00000328674

    UniGene: Hs.533779



主站蜘蛛池模板： 高潮毛片无遮挡高清视频播放| 欧美日产国产精品日产| 久久99精品久久久久蜜芽| 亚洲多毛妓女毛茸茸的| 国内揄拍国内精品少妇国语| 日本一区二区a√成人片| 在线观看无码av网站永久免费 | 色妞www精品视频| 最新国产乱人伦偷精品免费网站| 男女啪啪做爰高潮免费网站| 亚洲精品无码你懂的| 国产农村妇女高潮大叫| 国产超碰人人做人人爱ⅴa| 国产三区在线成人av| 国色天香精品一卡2卡3卡4| 成人做爰视频www| 酒店大战丝袜高跟鞋人妻| 国内少妇偷人精品免费| 天堂在线最新版www中文| 亚洲成av人片天堂网| 两个人看的www视频免费完整版| 老妇高潮潮喷到猛进猛出| 亚洲国产欧美在线看片一国产| 日本国产制服丝袜一区| 无码国内精品人妻少妇蜜桃视频| 成人区精品一区二区婷婷| 99999久久久久久亚洲| 亚洲国产精品无码观看久久| 人妻夜夜爽天天爽三区| 国产手机在线亚洲精品观看| 国产精品美女久久久久网站浪潮| 中国极品少妇xxxxx| 中文字幕亚洲乱码熟女在线 | 鲁鲁网亚洲站内射污| 5566先锋影音夜色资源站在线观看| 欧美午夜理伦三级在线观看| 又爽又黄又无遮挡网站| 人人妻人人澡人人爽精品欧美| 亚洲一区精品二人人爽久久| 欧美丰腴丰满大屁股熟妇| 欧美成人一卡二卡三卡四卡|