在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CLDN6 Antibody

  • 中文名稱:
    CLDN6兔多克隆抗體
  • 貨號:
    CSB-PA005508LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005508LA01HU at dilution of 1:100
    • Immunofluorescence staining of HepG2 cells with CSB-PA005508LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CLDN6 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CLDN6; UNQ757/PRO1488; Claudin-6; Skullin
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Claudin-6 protein (182-220AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CLDN6 Antibody (CSB-PA005508LA01HU),的標記方式是Non-conjugated。對于CLDN6 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA005508LB01HU CLDN6 Antibody, HRP conjugated ELISA
    FITC CSB-PA005508LC01HU CLDN6 Antibody, FITC conjugated
    Biotin CSB-PA005508LD01HU CLDN6 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a major role in tight junction-specific obliteration of the intercellular space.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
  • 基因功能參考文獻:
    1. Antibodies recognizing native CLDN6 as displayed on cell surfaces and mediating complement-dependent cytotoxicity were elicited in vaccinated animals. The data suggest applications of CLDN6 displaying Virus-like particles in cancer immunotherapy. PMID: 29131519
    2. these results suggest that Helicobacter pylori lipopolysaccharide induces TLR2 expression in the gastric adenocarcinoma cells, and that the longer the exposure to lipopolysaccharide, the greater the expression of TLR2 in the cell membrane; consequently the expression of claudin-4, -6, -7 and -9 also increases PMID: 29031421
    3. Study provides evidence that high expression of CLDN6 confers chemoresistance on breast cancer which is mediated by GSTP1, the activity of which is regulated by p53. PMID: 29116019
    4. CLDN6 enhances the chemoresistance to ADM via activating the AF-6/ERK signaling pathway and up-regulating cancer stem cell characters in MDAMB231 cells. PMID: 29159771
    5. we demonstrated that the downregulation of CLDN6 is regulated through promoter methylation by DNMT1, which depends on the SMAD2 pathway, and that CLDN6 is a key regulator in the SMAD2/DNMT1/CLDN6 pathway to inhibit EMT, migration and invasion of breast cancer cells PMID: 28867761
    6. In conclusion, this information from bioinformatics analysis will help future attempts to better understand CLDN6 regulation and functions. PMID: 28656265
    7. high expression of CLDN 6 was observed in approx. 65% of the myxofibrosarcomas, whereas the benign soft tissue tumors did not show a high expression of CLDN 6. The expression of CLDN 6 in the myxofibrosarcomas was significantly higher than those of other tumor specimens. Among the myxofibrosarcomas, the high expression of CLDN 6 was correlated with high FNCLCC grades and high AJCC stages. PMID: 28476380
    8. Results show that DNA methylation down-regulates CLDN6 expression through MeCP2 binding to the CLDN6 promoter, deacetylating H3 and H4, and altering chromatin structure, consequently promoting migratory and invasive phenotype in breast cancer cells. PMID: 27461117
    9. Cldn6 was decreased in alveolar type II-like epithelial cells (A549) and primary small airway epithelial cells when exposed to cigarette smoke ext PMID: 27982694
    10. suggest that claudin-6 induces MMP-2 activation through claudin-1 membrane expression PMID: 27914788
    11. Data show that claudin-6 (CLDN6) R209Q and occludin (OCLN) P24A mutations do not affect HCV pseudoparticles (HCVpp) entry. PMID: 26561856
    12. The expression of ASK1 is correlated with the level of claudin-6 in cervical carcinoma cells and tissues. PMID: 26191261
    13. High levels of CLDN6 are associated with non-small-cell lung cancer. PMID: 24710653
    14. The expression of claudin-6 was down regulated in gastric cancer tissue. PMID: 23919729
    15. Only some hepatitis C virus strains efficiently use CLDN6 for infection. PMID: 23775920
    16. This work provides a proof of concept for the use of Claudin-6 to eliminate residual undifferentiated human pluripotent stem cells from culture. PMID: 23778593
    17. Although claudin-6 and claudin-9 can serve as entry factors in cell lines, hepatitis C virus infection into human hepatocytes is not dependent on claudin-6 and claudin-9. PMID: 23864633
    18. ASK1 signal may play a positive role in the inhibitory effect of claudin-6 in breast cancer. PMID: 22925655
    19. Our results show that claudin-6 protein is significantly down-regulated in breast invasive ductal carcinomas PMID: 22455563
    20. CLDN6 is not a specific biomarker for atypical teratoid rhabdoid tumors as it is expressed in a variety of other pediatric CNS and soft tissue tumors. PMID: 21989342
    21. 17beta-E2 might regulate the expression of claudin-6 and inhibit the proliferation and migration of MCF-7 cells. PMID: 20388399
    22. Increased expression of claudin-6, claudin-7, or claudin-9 is sufficient to enhance tumorigenic properties of a gastric adenocarcinoma cell line. PMID: 20874001
    23. CLDN6 may be a useful positive marker to help further identify atypical teratoid/rhabdoid tumors for diagnostic and treatment purposes PMID: 19220299
    24. Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis PMID: 19960275
    25. The up-regulation of claudin-6 expression in MCF-7 breast cancer cells suppresses their malignant phenotypes with a correlation with the restoration of tight junction integrity. PMID: 20367941
    26. claudin-6, downregulates the malignant phenotype of breast carcinoma. PMID: 20215972
    27. Claudin 6 was not found in epithelioid glioblastomas or rhabdoid glioblastomas. PMID: 20118769
    28. CLDN6 and CLDN9, but not CLDN1, are expressed in peripheral blood mononuclear cells, an additional site of HCV replication. PMID: 17804490
    29. claudin-6 and claudin-9 expressed in CD81+ cells also enable the entry of HCV pseudoparticles derived from six of the major genotypes. PMID: 18234789
    30. CLDN6, clustered with CLDN9 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 組織特異性:
    Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
  • 數據庫鏈接:

    HGNC: 2048

    OMIM: 615798

    KEGG: hsa:9074

    STRING: 9606.ENSP00000328674

    UniGene: Hs.533779



主站蜘蛛池模板: 激情国产一区二区三区四区| 日本公妇乱偷中文字幕| 亚洲色欲色欱www在线| 久久成人影院精品777| 丰满少妇作爱视频免费观看| 久久精品av麻豆| 国产片精品av在线观看夜色| 国精品99久9在线 | 免费| 国产精品门事件av| 亚洲中文字幕久久精品蜜桃| 国产乱子伦精品无码专区| 中文字幕人成乱码熟女| 香港三级日本三级a视频| 日本中文一二区有码在线| 精品人妻伦一二三区久久aaa片| 欧美人与牲动交xxxx| 国产又黄又猛又粗又爽的a片动漫 成年女性特黄午夜视频免费看 | 色狠狠久久av五月综合| 麻豆亚洲国产成人精品无码区| 9久9久女女热精品视频在线观看| 99久久久国产精品消防器材| 亚洲日韩一区精品射精| 国产精品夜间视频香蕉| 色综合天天视频在线观看| 日产欧美国产日韩精品| 亚洲一区二区三区中文字幕在线| 无遮挡裸体免费视频尤物| 处破痛哭a√18成年片免费| 国产av一区二区精品凹凸| 国产又黄又湿无遮挡免费视频| 日本无遮挡边做边爱边摸| 欧洲熟妇性色黄| 欧美人与动交视频在线观看| 国产乱人伦av在线麻豆a | 国产在线高清亚洲精品二区| 欧美 日韩 国产 另类 图片区| 亚洲丰满熟女一区二区v| 鲁一鲁一鲁一鲁一澡| 色综合视频一区中文字幕| 潮喷无码正在播放| 337p日本欧洲亚洲大胆裸体艺术|