在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CFD (lampalizumab) Recombinant Monoclonal Antibody

  • 中文名稱:
    CFD (lampalizumab) Recombinant Monoclonal Antibody
  • 貨號:
    CSB-RA005271MA1HU
  • 規格:
    ¥1320
  • 圖片:
    • The Binding Activity of Human CFD with Anti-CFD Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CFD (CSB-MP005271HU) at 2 μg/mL can bind Anti-CFD recombinant antibody. The EC50 is 31.86-39.21 ng/mL.
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Complement factor D (EC 3.4.21.46) (Adipsin) (C3 convertase activator) (Properdin factor D), CFD, DF PFD
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human CFD protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    hIgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    3F10
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:5000-1:50000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
  • 基因功能參考文獻:
    1. MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked. PMID: 27535802
    2. disturbance of reciprocal relationships between adipsin and leptin in obesity is associated with the development of insulin resistance PMID: 28864895
    3. TZDs (pioglitazone, rosiglitazone, and ciglitazone) slow tumor cell growth in vitro and in vivo with decreases in cell proliferation and increases in PPARg and adipsin PMID: 28219679
    4. The strong association of PLIN1, CFD and ADIPOQ genes with adipogenesis prompted authors to study the influence the bone health status as evaluated by quantitative ultrasound (QUS) bone densitometer in a North Indian cohort. Overall, ADIPOQ (rs1501299 and rs3774261) and combined cluster of PLIN1 rs2304796 and rs2304795) and CFD (rs1683563) demonstrated correlation. PMID: 28189761
    5. our findings set up a novel mechanism for FABP4, adipsin and adiponectin through gut microbiota mediating expression in gut Paneth cells. PMID: 26687459
    6. Overall adipsin levels among male asbestos industry workers were significantly higher than among control subjects. PMID: 25840635
    7. Data indicate that a urinary protein, adipsin, was significantly increased in patients with preeclampsia. PMID: 24958499
    8. Study demonstrates that T2DM patients with beta cell failure are deficient in adipsin. PMID: 24995977
    9. Complement factor D (FD) is activated by its substrate through interactions outside the active site which lock the unbound native state into an ordered inactive conformation via the self-inhibitory loop in FD. PMID: 24598742
    10. We demonstrate novel secretion of adipsin and ASP by placental Hofbauer cells. PMID: 23956345
    11. Increased activation of the alternative complement pathway in vitreous was controlled by disease stage and genetic variation in the complement pathway, supporting a role for complement activation in macular degeneration disease pathogenesis. PMID: 22930722
    12. Anti factor D Fab fragment inhibits FD proteolytic function by interfering with macromolecular substrate access rather than by inhibiting FD catalysis. PMID: 22362762
    13. CFD regulates activation of the alternative complement pathway, which is implicated in age related macular degeneration pathogenesis. PMID: 22003108
    14. CFD may not play a major role in the genetic susceptibility to age-related macular degeneration. PMID: 21139680
    15. crystal structure of C3bB at 4 A and complex with factor D at 3.5 A; data show how factor B binding to C3b forms open "activation" state of C3bB; Factor D binds open conformation of factor B through a site distant from the catalytic center PMID: 21205667
    16. As adiponectin and adipsin levels in CSF did not correlate with their levels in plasma, it seems that there could be a secondary intrathecal synthesis of these adipocytokines in multiple sclerosis PMID: 19538214
    17. increased serum levels in patients with seasonal allergic rhinitis PMID: 19699327

    顯示更多

    收起更多

  • 相關疾病:
    Complement factor D deficiency (CFDD)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Peptidase S1 family
  • 數據庫鏈接:

    HGNC: 2771

    OMIM: 134350

    KEGG: hsa:1675

    STRING: 9606.ENSP00000332139

    UniGene: Hs.155597



主站蜘蛛池模板: 国产看黄网站又黄又爽又色| 五十路熟妇高熟无码视频| 欧美自拍另类欧美综合图片区 | 日产精品久久久一区二区| 无码中文字幕日韩专区视频| 国产av无码专区亚洲awww| 精品无码综合一区二区三区| 国产日韩精品视频无码| 欧美在线观看免费专区| 久久久久人妻精品一区三寸蜜桃 | 色先锋影音岛国av资源| 日本乱码伦午夜福利在线| 欧美颜射内射中出口爆在线| 天天躁夜夜踩很很踩2022| 国精品午夜福利视频| 国自产拍偷拍精品啪啪av| 亚洲一区二区三区四区五区六| 中文字幕欧美日韩va免费视频| 狠人干练合综合网| 西欧free性满足hd| 丰满少妇人妻无码专区| 国产97色在线 | 国产| 在线 亚洲 国产 欧美| 国产成人夜色高潮福利影视| 97爱亚洲综合成人| 正在播放老肥熟妇露脸| 久久精品2021国产| 无码任你躁久久久久久老妇蜜桃 | 先锋人妻无码av电影| 99在线精品视频高潮喷吹| 人妻少妇精品久久| 成人亚洲欧美成αⅴ人在线观看| 猫咪www免费人成网站无码 | 又色又爽又黄高潮的免费视频| 国产精品亚洲lv粉色| 97视频精品全国免费观看| 久久草莓香蕉频线观| 欧美肉大捧一进一出免费视频| 两根大肉大捧一进一出好爽视频| 亚洲人成网站在线无码| 狠狠噜天天噜日日噜视频麻豆|