在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CDH17 Recombinant Monoclonal Antibody

  • 中文名稱:
    CDH17重組抗體
  • 貨號:
    CSB-RA613267MA1HU
  • 規格:
    ¥1320
  • 圖片:
    • The Binding Activity of Human CDH17 with Anti-CDH17 Recombinant Antibody
      Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH17 (CSB-MP613267HU) at 2 μg/mL can bind Anti-CDH17 recombinant antibody, the EC50 is 3.095-4.451 ng/mL.
    • Untransfected HEK293T cells surface (green line) and transfected Human CDH17 HEK293T stable cells surface (red line) were stained with anti-CDH17 antibody (2μg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
  • 其他:

產品詳情

  • 產品描述:
    CDH17 Recombinant Monoclonal Antibody(CSB-RA613267MA1HU)是特異性識別鈣粘蛋白17(Cadherin-17)的高性能抗體試劑,適用于ELISA和流式細胞術(FC)檢測。CDH17作為鈣粘蛋白家族成員,在維持細胞間粘附和上皮組織完整性中發揮重要作用,其異常表達與消化道腫瘤發生及轉移密切相關。該抗體通過重組技術制備,具有高批次間一致性和穩定性,ELISA驗證顯示其具備優異的靈敏度與線性檢測范圍,流式細胞術驗證證實其可精準識別細胞表面天然構象的CDH17蛋白。在科研領域,該產品適用于腫瘤微環境研究、細胞極性調控機制探索、轉移性癌癥分子標志物分析等方向,為體外實驗中靶蛋白的定量檢測及細胞表型鑒定提供可靠工具。本產品經嚴格驗證,不適用于臨床診斷或治療用途。
  • Uniprot No.:
  • 基因名:
  • 別名:
    Cadherin-17; Intestinal peptide-associated transporter HPT-1; Liver-intestine cadherin (LI-cadherin); CDH17
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human CDH17 protein
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Monoclonal
  • 抗體亞型:
    hIgG1
  • 純化方式:
    Affinity-chromatography
  • 克隆號:
    10B3
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, FC
  • 推薦稀釋比:
    Application Recommended Dilution
    FC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine. Involved in intestinal peptide transport.
  • 基因功能參考文獻:
    1. CDH17 has a role in altering MMP-2 expression via canonical NF-kappaB signalling in human gastric cancer PMID: 29783070
    2. Data show that alteration in beta-catenin expression, a core component of the CDH17/beta-catenin axis, in tumors affects serine peptidase inhibitor Kazal type 1 (SPINK1) serum levels in hepatocellular carcinoma (HCC) patients. PMID: 28631187
    3. However, CDH17 expression was significantly elevated in patients with stage II and III gastric cancers compared to that in healthy controls (p= 0.023 and p= 0.037, respectively). PMID: 28453457
    4. CDH17 and CLDN18 are useful target molecules. Their coupling can aid in the comprehensive detection and localization of gastric cancer metastases in vivo to overcome challenges associated with intratumoral heterogeneity. PMID: 27580354
    5. CDH17 is a sensitive marker for midgut WDNETs, and the CDH17+/CDX2-/TTF1- phenotype was found to be sensitive (92%) and specific (91%) for hindgut well-differentiated neuroendocrine tumours (WDNETs). PMID: 25388236
    6. Using a lentiviral system as a delivery mediator of RNA interference, we found that inhibition of CDH17 can lead to reduce proliferation and increase apoptosis of gastric cancer cell line MKN28 in vitro and significantly diminish their tumorigenicity in vivo. Our results of the present study suggest that CDH17 may be a promising candidate for the therapeutic targeting of gastric cancer. PMID: 27909714
    7. In stomach adenocarcinomas, CDH17 positively stained 64.0% (112 of 175) of tissues, compared to CK20 and CDX2, where staining was observed in only 24.6% (43 of 175) and 46.9% (82 of 175), respectively. PMID: 28029907
    8. These data indicate that knockdown of LIcadherin facilitates the invasion of cancer cells by degrading extracellular matrix components via activation of MMP2 and 9, and increases cancer cell adhesion and migration via altered expression of galectin3. PMID: 27035870
    9. Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC. PMID: 26743780
    10. Mutations in CDH17 gene is associated with idiopathic hypereosinophilic syndrome. PMID: 26497854
    11. Review/Meta-analysis: data reflect the role of CDH17 in tumor proliferation and metastasis among gastric cancer patients. PMID: 25834338
    12. CDH17 is a sensitive (81%) and highly specific (100%) marker for metanephric adenoma. PMID: 25768256
    13. RGD motif present in cadherin 17 induces integrin activation and tumor growth PMID: 25336636
    14. Data suggest that combined tumor expression of CDH17 (cadherin-17) and SATB2 (special AT-rich sequence binding protein 2) may be used as diagnostic biomarkers in subjects with medullary carcinoma of the large intestine (colon; cecum). PMID: 24437456
    15. Data reveal a new function for CDH17, which is to regulate alpha2beta1 integrin signaling in cell adhesion and proliferation in colon cancer cells for liver metastasis. PMID: 23604127
    16. The SNPs of the CDH17 gene c.2216 A>C might be clinically important in the prognosis of colorectal carcinoma. PMID: 23326130
    17. This study demonstrates that the secreted form of cadherin-17 (ectodomain) is truncated at the C-terminus. PMID: 23557862
    18. results identify CDH17 as a biomarker of gastric carcinoma and attractive therapeutic target for this aggressive malignancy. PMID: 23554857
    19. Cadherin-17 induces tumorigenesis and lymphatic metastasis in gastric cancer through activation of NFkappaB signaling pathway. PMID: 23298905
    20. LI-cadherin is a sensitive marker of intestinal metaplasia and can be helpful for early histologic diagnosis of Barrett's esophagus (BE); it is not, however, significantly different between BE with and without intestinal epithelial neoplasia. PMID: 23053896
    21. Up-regulation of cadherin 17 is associated with epithelial ovarian cancer progression. PMID: 22810971
    22. Report less aggressive behavior of gastric tumors after CDH17 gene knockdown. PMID: 22791949
    23. CDH17 was positively associated with larger tumor size, deeper invasion, diffuse/mixed histotype, LVI, and LNMM, predicting a poor prognosis in pN0 gastric cancer. PMID: 22009269
    24. LI cadherin is associated with an intestinal phenotype and an 'intestinal pathway' of carcinogenesis in intraductal papillary mucinous neoplasm. PMID: 22286087
    25. we proposed that CDH17 may be an oncogene up-regulating invasive features of gastric cancer cells PMID: 20393816
    26. CDH17 expression may be well preserved during the metastatic process and therefore be a useful marker for identifying colorectal adenocarcinomas in a metastatic setting with an unknown primary site PMID: 21323956
    27. Targeting CDH17 in HCC can inhibit tumor growth and inactivate Wnt signaling pathway in concomitance with activation of tumor suppressor genes.[review] PMID: 20580775
    28. CDX2 and LI-cadherin are sensitive markers of intestinal metaplasia with or without dysplasia in the upper gastrointestinal tract. PMID: 20444732
    29. identified the minimal promoter region of CDH17 that is regulated by HNF1alpha and CDX2 transcriptional factors; Suppression of HNF1alpha and CDX2 expression by siRNA down-regulated expressions of CDH17 and cyclin D1 and the viability of HCC cells PMID: 20568120
    30. Li-cadherin participates in the multiple steps of invasion and metastasis in a colorectal cancer cell line. PMID: 20204409
    31. CDH17 maybe a positive regulator for proliferative, adhesive, and invasive behaviors of gastric cancer. PMID: 20500517
    32. Expression of CDH17 and MUC13 was up-regulated in gastric cancer tissues. CDH17 is a promising prognostic marker for early stage gastric cancer. PMID: 20398667
    33. Loss of LI-cadherin results in up-regulation of MTF-1 and PlGF, thereby regulating angiogenesis in intrahepatic cholangiocarcinoma PMID: 19956853
    34. High xpression of liver-intestine cadherin and its possible interaction with galectin-3 is associated with ductal adenocarcinoma of the pancreas PMID: 12824888
    35. tumor staging and LI-cadherin expression were found to be independent factors associated with lymph node metastasis. PMID: 15178443
    36. LI-cadherin may have a role in lymph node metastasis and progression of human colorectal carcinoma PMID: 15279905
    37. Aberrant alternative splicing of LI-cadherin is associated with hepatocellular carcinoma PMID: 15701831
    38. The functional T-G haplotype of CDH17 (651 C>T and IVS6+35A>G) is a genetic susceptibility factor for the development of Hepatocellular carcinoma (HCC) in a Chinese population. PMID: 16951245
    39. Reduced expression of liver intestine-cadherin had a significant correlation with tumoral dedifferentiation and short overall survival in colorectal cancer. PMID: 17828401
    40. combined detection of CDH17/CDX2 co-expression may benefit us in predicting the prognosis of gastric carcinoma. PMID: 18353622
    41. Cadherin-17 is a useful immunohistochemical marker for diagnosis of adenocarcinomas of the digestive system. PMID: 18552820
    42. CDH17 is a novel oncogene in hepatocellular carcinoma. CDH17 is a biomarker and attractive therapeutic target for this aggressive malignancy. PMID: 19676131

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Expressed in the gastrointestinal tract and pancreatic duct. Not detected in kidney, lung, liver, brain, adrenal gland and skin.
  • 數據庫鏈接:

    HGNC: 1756

    OMIM: 603017

    KEGG: hsa:1015

    STRING: 9606.ENSP00000027335

    UniGene: Hs.591853



主站蜘蛛池模板: 欧美成人精精品一区二区| 国产成人一区二区无码不卡在线| 国产三级精品三级在线专1| 成·人免费午夜视频香蕉| 国产精品系列无码专区| 欧美又粗又大xxxxbbbb疯狂| 天天做天天摸天天爽天天爱| 国产毛多水多高潮高清| 久久综合一色综合久久小蛇| 国产熟妇另类久久久久久| 男女做爰无遮挡性视频| 狠狠躁18三区二区一区ai明星 | 久精品国产欧美亚洲色aⅴ大片| 日本少妇高潮喷水免费可以看| 欧美国产日韩a欧美在线观看| 国产精品一区二区 尿失禁| 天天躁日日躁狠狠躁一区| 亚洲日韩av无码中文字幕美国 | 久久99国产综合精品免费| 亚洲有无码av在线播放| 亚洲中文字幕伊人久久无码| 欧洲国产精品无码专区影院| 亚洲欧美综合区自拍另类| 日韩欧美一区二区三区免费观看| 亚洲国产精品无码专区| 亚洲精品综合在线影院| 天干天干啦夜天干天天爽| 午夜人妻久久久久久久久| 日本亲与子乱人妻hd| 欧美一道本一区二区三区| 亚洲性av网站| 无码人妻一区二区三区免费手机| 天天弄天天模| 欧洲美女黑人粗性暴交视频| 亚洲精品无码久久久影院相关影片 | 先锋影音男人av资源| 久久国产36精品色熟妇| 色欲久久人妻内射| 国产制服丝袜欧美在线观看| 亚洲综合国产成人丁香五月激情| 久久久久99人妻一区二区三区|