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  4. CD3E Recombinant Monoclonal Antibody

CD3E Recombinant Monoclonal Antibody

  • 中文名稱：
    CD3E重組抗體
  • 貨號：
    CSB-RA004931MA1HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Overlay Peak curve showing JK cells surface stained with CSB-RA004931MA1HU (red line) at 1:100. Then 10% normal goat serum was Incubated to block non-specific protein-protein interactions followed by the antibody (1μg/1*106cells) for 45 min at 4°C. The secondary antibody used was FITC-conjugated Goat Anti-Mouse IgG(H+L) at 1/200 dilution for 35 min at 4°C. Isotype control antibody (green line) was mouse IgG1 (1μg/1*106cells) used under the same conditions. Acquisition of >10, 006 events was performed.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：
    CD3E重組單克隆抗體（CSB-RA004931MA1HU）是針對T細(xì)胞表面CD3復(fù)合體ε鏈的高特異性科研工具，該靶標(biāo)分子在T細(xì)胞受體（TCR）信號傳導(dǎo)及免疫激活中發(fā)揮核心作用。本抗體經(jīng)ELISA和流式細(xì)胞術(shù)（FC）嚴(yán)格驗(yàn)證，在推薦稀釋比例（FC 1:20-1:500）范圍內(nèi)展現(xiàn)出優(yōu)異的抗原結(jié)合能力，適用于天然及重組CD3E蛋白的精準(zhǔn)檢測。其高靈敏度和低交叉反應(yīng)性特點(diǎn)，可支持研究人員在多種實(shí)驗(yàn)體系中分析T細(xì)胞表面標(biāo)志物的表達(dá)模式，尤其適用于免疫細(xì)胞分群、T細(xì)胞活化狀態(tài)評估以及免疫調(diào)節(jié)機(jī)制研究。該產(chǎn)品在體外實(shí)驗(yàn)?zāi)Ｐ椭袨樘剿鱐細(xì)胞介導(dǎo)的免疫應(yīng)答、自身免疫性疾病機(jī)制及腫瘤微環(huán)境中的免疫調(diào)控提供了可靠工具，同時滿足藥物開發(fā)過程中靶點(diǎn)驗(yàn)證及功能研究的標(biāo)準(zhǔn)化需求。采用重組單克隆抗體技術(shù)生產(chǎn)，具備批次間高度一致性，適用于高通量篩選和定量分析等精細(xì)化實(shí)驗(yàn)設(shè)計(jì)。
  • Uniprot No.：
  • 基因名：
  • 別名：
    CD3 epsilon antibody; CD3e antibody; CD3e antigen antibody; CD3e antigen epsilon polypeptide (TiT3 complex) antibody; CD3E antigen epsilon polypeptide antibody; CD3E antigen, epsilon subunit antibody; CD3e molecule epsilon antibody; CD3e molecule, epsilon (CD3 TCR complex) antibody; CD3e molecule, epsilon (CD3-TCR complex) antibody; CD3E_HUMAN antibody; IMD18 antibody; T cell antigen receptor complex epsilon subunit of T3 antibody; T cell surface antigen T3/Leu 4 epsilon chain antibody; T cell surface glycoprotein CD3 epsilon chain antibody; T-cell surface antigen T3/Leu-4 epsilon chain antibody; T-cell surface glycoprotein CD3 epsilon chain antibody; T3E antibody; TCRE antibody
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human CD3E protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Mouse IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號：
    25E11
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, FC
  • 推薦稀釋比：
    Application Recommended Dilution
    FC 1:20-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
  • 基因功能參考文獻(xiàn)：
    1. The ionic CD3-epsilon -Lck interaction controls the phosphorylation level of the T-cell receptor. PMID: 28659468
    2. A novel pathogenic frameshift variant of CD3E gene has been found in two unrelated T-B+ NK+ severe combined immunodeficiency infants from Turkey. PMID: 28597365
    3. the stalk domains of NKp30 and NKp46, another NCR employing CD3zeta for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling. PMID: 27754869
    4. The inducible recruitment of WASp to the TCR-CD3 complex is partially dependent of tyrosine phosphorylation of Cd3e. PMID: 26342115
    5. increase. Our results indicate that the change in CD3zeta-chain expression from the baseline is an independent predictor of residual and recurrent head and neck squamous cell carcinoma. PMID: 26888626
    6. Data suggest that HIV-1 gp41 transmembrane domain (TMD) directly interacts with TMDs of the T-cell receptor and it's CD3-antigen co-receptors (delta, gamma, and epsilon); these interactions appear to be involved in immune evasion mechanism of HIV-1. PMID: 26828096
    7. that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response. PMID: 24470497
    8. ABCB1 homozygous 3435 TT carrier subjects showed the lowest Pgp activity compared with 3435 CT and CC carriers of renal transplant patients. PMID: 23216707
    9. Local changes in the lipid composition of TCR microclusters render the CD3epsilon cytoplasmic domain accessible during early stages of T cell activation. PMID: 23166358
    10. Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas. PMID: 21980389
    11. analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice PMID: 21203507
    12. Results suggest that generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a general phenomenon. PMID: 19616027
    13. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. PMID: 12110186
    14. T cell receptor can be recruited to a subset of plasma membrane rafts, independently of cell signaling and attendantly to raft clustering PMID: 12499387
    15. SCID is caused by a CD3E deficiency. PMID: 15546002
    16. CD3 expression was strong in normal proximal and distal tubular epithelium and in renal oncocytomas, weak in chromophobe carcinoma, and negative in clear cell carcinomas, in papillary renal cell carcinoma, and in a transitional cell carcinoma. PMID: 16308105
    17. The CD3 epsilon immune recognition receptor cytoplasmic domain binds to acidic and mixed phospholipid vesicles with a binding strength that correlates with the protein net charge and the presence of clustered basic amino acid residues. PMID: 17176095
    18. CD3epsilon-mediated signal transduction pathway is essential for this transformation process PMID: 17507663
    19. Notch-dependent cytoplasmic CD3 expression can only be achieved during the early phase of NK-cell differentiation. PMID: 17630354
    20. In lung adenocarcinoma patients, significant decreases of MFI values for CD3epsilon, but not CD3zeta, were found in CD4+T and CD8+T cells from pleural effusion compared to peripheral blood and in peripheral blood of patients compared to healthy donors. PMID: 17668204
    21. Data show that Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the activation motif and a T-cell receptor endocytosis signal. PMID: 18555270
    22. Data show that anti-CD3 monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 MAb isotype and is not governed by Siglec expression. PMID: 18667496
    23. Results revealed that the human CD3 epsilon subunit forms a homodimer structure, which provide insight into our understanding of the molecular assembly of the CD3 molecular complex. PMID: 19724882

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  • 相關(guān)疾病：
    Immunodeficiency 18 (IMD18)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1674

    OMIM: 186830

    KEGG: hsa:916

    STRING: 9606.ENSP00000354566

    UniGene: Hs.3003



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