在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CD3E Antibody

  • 中文名稱:
    CD3E兔多克隆抗體
  • 貨號:
    CSB-PA004931HA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human lymph node tissue using CSB-PA004931HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA004931HA01HU at dilution of 1:100
    • Immunofluorescent analysis of A549 cells using CSB-PA004931HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CD3E Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CD3 epsilon antibody; CD3e antibody; CD3e antigen antibody; CD3e antigen epsilon polypeptide (TiT3 complex) antibody; CD3E antigen epsilon polypeptide antibody; CD3E antigen, epsilon subunit antibody; CD3e molecule epsilon antibody; CD3e molecule, epsilon (CD3 TCR complex) antibody; CD3e molecule, epsilon (CD3-TCR complex) antibody; CD3E_HUMAN antibody; IMD18 antibody; T cell antigen receptor complex epsilon subunit of T3 antibody; T cell surface antigen T3/Leu 4 epsilon chain antibody; T cell surface glycoprotein CD3 epsilon chain antibody; T-cell surface antigen T3/Leu-4 epsilon chain antibody; T-cell surface glycoprotein CD3 epsilon chain antibody; T3E antibody; TCRE antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human T-cell surface glycoprotein CD3 epsilon chain protein (23-126AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CD3E Antibody (CSB-PA004931HA01HU),的標記方式是Non-conjugated。對于CD3E Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA004931HB01HU CD3E Antibody, HRP conjugated ELISA
    FITC CSB-PA004931HC01HU CD3E Antibody, FITC conjugated
    Biotin CSB-PA004931HD01HU CD3E Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.
  • 基因功能參考文獻:
    1. The ionic CD3-epsilon -Lck interaction controls the phosphorylation level of the T-cell receptor. PMID: 28659468
    2. A novel pathogenic frameshift variant of CD3E gene has been found in two unrelated T-B+ NK+ severe combined immunodeficiency infants from Turkey. PMID: 28597365
    3. the stalk domains of NKp30 and NKp46, another NCR employing CD3zeta for signaling, were not exchangeable without drastic deficiencies in folding, plasma membrane targeting, and/or ligand-induced receptor signaling. PMID: 27754869
    4. The inducible recruitment of WASp to the TCR-CD3 complex is partially dependent of tyrosine phosphorylation of Cd3e. PMID: 26342115
    5. increase. Our results indicate that the change in CD3zeta-chain expression from the baseline is an independent predictor of residual and recurrent head and neck squamous cell carcinoma. PMID: 26888626
    6. Data suggest that HIV-1 gp41 transmembrane domain (TMD) directly interacts with TMDs of the T-cell receptor and it's CD3-antigen co-receptors (delta, gamma, and epsilon); these interactions appear to be involved in immune evasion mechanism of HIV-1. PMID: 26828096
    7. that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response. PMID: 24470497
    8. ABCB1 homozygous 3435 TT carrier subjects showed the lowest Pgp activity compared with 3435 CT and CC carriers of renal transplant patients. PMID: 23216707
    9. Local changes in the lipid composition of TCR microclusters render the CD3epsilon cytoplasmic domain accessible during early stages of T cell activation. PMID: 23166358
    10. Results show that levels of CD3epsilon, CD25, CD68, and ICAM-1 mRNA in BCC biopsies may predict risk for new basal cell carcinomas. PMID: 21980389
    11. analysis of the transgenic integration site in immunodeficient tgepsilon26 human CD3epsilon transgenic mice PMID: 21203507
    12. Results suggest that generation of CD3varepsilon chain isoforms with different N-terminal sequence and pI is a general phenomenon. PMID: 19616027
    13. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. PMID: 12110186
    14. T cell receptor can be recruited to a subset of plasma membrane rafts, independently of cell signaling and attendantly to raft clustering PMID: 12499387
    15. SCID is caused by a CD3E deficiency. PMID: 15546002
    16. CD3 expression was strong in normal proximal and distal tubular epithelium and in renal oncocytomas, weak in chromophobe carcinoma, and negative in clear cell carcinomas, in papillary renal cell carcinoma, and in a transitional cell carcinoma. PMID: 16308105
    17. The CD3 epsilon immune recognition receptor cytoplasmic domain binds to acidic and mixed phospholipid vesicles with a binding strength that correlates with the protein net charge and the presence of clustered basic amino acid residues. PMID: 17176095
    18. CD3epsilon-mediated signal transduction pathway is essential for this transformation process PMID: 17507663
    19. Notch-dependent cytoplasmic CD3 expression can only be achieved during the early phase of NK-cell differentiation. PMID: 17630354
    20. In lung adenocarcinoma patients, significant decreases of MFI values for CD3epsilon, but not CD3zeta, were found in CD4+T and CD8+T cells from pleural effusion compared to peripheral blood and in peripheral blood of patients compared to healthy donors. PMID: 17668204
    21. Data show that Nck forms a complex with an atypical PxxDY motif of the CD3epsilon tail, which encompasses Tyr166 within the activation motif and a T-cell receptor endocytosis signal. PMID: 18555270
    22. Data show that anti-CD3 monoclonal antibody (MAb)-mediated chimpanzee T-cell activation is a function of the anti-CD3 MAb isotype and is not governed by Siglec expression. PMID: 18667496
    23. Results revealed that the human CD3 epsilon subunit forms a homodimer structure, which provide insight into our understanding of the molecular assembly of the CD3 molecular complex. PMID: 19724882

    顯示更多

    收起更多

  • 相關疾病:
    Immunodeficiency 18 (IMD18)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 數據庫鏈接:

    HGNC: 1674

    OMIM: 186830

    KEGG: hsa:916

    STRING: 9606.ENSP00000354566

    UniGene: Hs.3003



主站蜘蛛池模板: 2020最新无码国产在线观看| 欧美乱妇狂野欧美在线视频| 国产精品成人va在线观看| 少妇被粗大的猛进69视频| 中文无码字幕中文有码字幕| 18禁止观看强奷免费国产大片| 影音先锋啪啪av资源网站| 国产95在线 | 亚洲| 日本熟妇人妻xxxxx| 亚洲国产v高清在线观看| 久久久精品中文字幕乱码18| 中文字幕日韩人妻在线视频| 四虎亚洲中文字幕无码永久 | 综合无码一区二区三区| 日韩精品一区二区三区中文| 国产欧美日韩另类在线专区 | 免费人成视频| 精品久久久久久成人av| 野外少妇被弄到喷水在线观看| 国产成人高清亚洲一区妲妃| 少妇被又大又粗又爽毛片久久黑人 | 色狠狠色噜噜av天堂一区| 女人爽到喷水的视频大全| 国产三级农村妇女在线 | 亚洲中久无码永久在线观看同| 日产电影一区二区三区| 久久久喷潮一区二区三区| 日本真人边吃奶边做爽电影| 任我爽精品视频在线播放| 情欲少妇人妻100篇| av区无码字幕中文色| 久久无码专区国产精品| 性人久久网av| 精品一卡二卡三卡四卡网站| 亚洲精品一区久久久久| 4hu四虎永久免费地址ww416| 欲色影视天天一区二区三区色香欲 | 日本少妇内射视频播放舔| 国产精品中文久久久久久久| 亚洲国产av高清无码| 亚洲综合色噜噜狠狠网站超清|