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  4. ACBD3 Recombinant Monoclonal Antibody

ACBD3 Recombinant Monoclonal Antibody

  • 中文名稱：
    ACBD3 Recombinant Monoclonal Antibody
  • 貨號(hào)：
    CSB-RA242921A0HU
  • 規(guī)格：
    ￥1320
  • 圖片：
    • Flow cytometric analysis of ACBD3 expression in HeLa cells using ACBD3 antibody. Green, isotype control; red, ACBD3.
    • Immunocytochemical staining of Hela cells with ACBD3 antibody. Nuclei were stained blue with DAPI; ACBD3 was stained magenta with Alexa Fluor? 647. Images were taken using Leica stellaris 5. Protein abundance based on laser Intensity and smart gain: Medium. Scale bar, 20 μm.
    • Western blotting analysis using ACBD3 antibody. Total cell lysates (30 μg) from various cell lines were loaded and separated by SDS-PAGE. The blot was incubated with ACBD3 antibody and HRP-conjugated goat anti-rabbit secondary antibody respectively.
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    ACBD3
  • 別名：
    ACBD3; Acyl-CoA Binding Domain Containing 3; GCP60; PBR- And PKA-Associated Protein 7; GOCAP1; GOLPH1; PAP7; Peripheral Benzodiazepine Receptor-Associated Protein PAP7; Acyl-Coenzyme A Binding Domain Containing 3; Golgi Complex Associated Protein 1, 60kDa; Golgi Resident Protein GCP60; Golgi Phosphoprotein 1; Acyl-CoA-Binding Domain-Containing Protein; Golgi Complex-Associated Protein 1; PKA (RIalpha)-Associated Protein
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human ACBD3 protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Monoclonal
  • 抗體亞型：
    Rabbit IgG
  • 純化方式：
    Affinity-chromatography
  • 克隆號(hào)：
    22E2
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Rabbit IgG in PBS (pH 7.4) containing 50% glycerol, and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, FC, ICC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    FC 1:200-1:2000
    ICC 1:100-1:1000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the maintenance of Golgi structure by interacting with giantin, affecting protein transport between the endoplasmic reticulum and Golgi. Involved in hormone-induced steroid biosynthesis in testicular Leydig cells. Recruits PI4KB to the Golgi apparatus membrane; enhances the enzyme activity of PI4KB activity via its membrane recruitment thereby increasing the local concentration of the substrate in the vicinity of the kinase.; (Microbial infection) Plays an essential role in Aichi virus RNA replication by recruiting PI4KB at the viral replication sites.
  • 基因功能參考文獻(xiàn)：
    1. These results reveal a mechanism of EV71 replication that involves host ACBD3 for viral replication. PMID: 28303920
    2. that ACBD3 may represent candidate therapeutic targets to enable the elimination of breast cancer stem cells PMID: 29307786
    3. ACBD3 was found as a gene expression variability marker in 8-cell human embryos. PMID: 26288249
    4. the component proteins of the machinery, OSBP, VAP, SAC1, and PITPNB, are all essential host factors for AiV replication. Importantly, the machinery is directly recruited to the RNA replication sites through previously unknown interactions of VAP/OSBP/SAC1 with the AiV proteins and with ACBD3. PMID: 29367253
    5. Results show that Aichi virus 3A protein activates the lipid kinase activity of PI4KIIIb,which activation is sensitized by the protein ACBD3. The interfaces between PI4KIIIbeta-ACBD3 and ACBD3-3A were mapped with hydrogen-deuterium exchange mass spectrometry. PMID: 27989622
    6. Kobuviral non-structural 3A proteins act as molecular harnesses to hijack the host ACBD3 protein. PMID: 28065508
    7. The authors propose a model in which interaction between Salmonella enterica serovar Typhimurium SseF and SseG enables both proteins to bind ACBD3, thereby anchoring Salmonella-containing vacuoles at the Golgi network and facilitating bacterial replication. PMID: 27406559
    8. these findings suggest that ACBD3 has prominent impacts on cellular NAD(+) metabolism via regulating PARP1 activation-dependent auto-modification and thus cell metabolism and function. PMID: 25940138
    9. Authors found that NS5A and PI4KB competed for association of acyl-coenzyme A binding domain containing protein 3 (ACBD3), which inhibited hepatitis C virus replication. PMID: 24792752
    10. Host ACBD3, PI4KIIIBETA and Aichi virus proteins complexes enhances phosphatidylinositol 4-phosphate synthesis and is critical for viral replication. PMID: 24672044
    11. ACBD3 mediates mHtt cytotoxicity via a Rhes/mHtt/ACBD3 complex. PMID: 24012756
    12. Authors found that the Golgi protein acyl-coenzyme A binding domain-containing 3 (ACBD3), interacts with the 3A proteins of poliovaccine Sabintpe 2 and coxsackievirus A17 at viral RNA replication sites. PMID: 23926333
    13. ACBD3 plays an essential role in maintaining lipid homeostasis via regulating SREBP1's processing pathway and thus impacting cellular lipogenesis. PMID: 23166793
    14. identified ACBD3 as an interacting partner of PPM1L, and showed that this association, which recruits PPM1L to ER-Golgi membrane contact sites, is mediated by a GOLD (Golgi dynamics) domain in ACBD3 PMID: 22796112
    15. The data were consistent with PAP7 interacting with DMT1 and regulating DMT1 expression in K562 cells by modulating expression of DMT1 protein. PMID: 22383495
    16. The 3A protein of picornaviruses utilizes the golgi adaptor protein ACBD3 to recruit PI4KIIIbeta. PMID: 22258260
    17. results indicate that a viral protein/ACBD3/PI4KB complex is formed to synthesize PI4P at the AiV RNA replication sites and plays an essential role in viral RNA replication PMID: 22124328
    18. Molecular cloning, chromosomal localization and expression pattern of PAP7. PMID: 12692076
    19. GCP60 interacts preferentially with one of the golgin-160 caspase cleavage fragments (residues 140-311). This strong interaction prevented the golgin-160 fragment from accumulating in the nucleus when this fragment and GCP60 were overexpressed. PMID: 16870622
    20. nuclear translocation of golgin-160-(140-311) is a highly coordinated event regulated not only by cleavage of the golgin-160 head but also by the oxidation state of GCP60 PMID: 17711851

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  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Mitochondrion.
  • 組織特異性：
    Ubiquitous, with highest expression in testis and ovary.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 15453

    OMIM: 606809

    KEGG: hsa:64746

    STRING: 9606.ENSP00000355777

    UniGene: Hs.520207



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