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  4. wnt8 Antibody

wnt8 Antibody

  • 中文名稱：
    wnt8兔多克隆抗體
  • 貨號：
    CSB-PA340936LA01XBE
  • 規格：
    ￥440
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Xenopus laevis wnt8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    wnt8
  • 別名：
    wnt8 antibody; Protein Wnt-8 antibody; XWnt-8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Xenopus laevis
  • 免疫原：
    Recombinant Xenopus laevis Protein Wnt-8 protein (23-358AA)
  • 免疫原種屬：
    Xenopus laevis
  • 標記方式：
    Non-conjugated

    本頁面中的產品，wnt8 Antibody (CSB-PA340936LA01XBE)，的標記方式是Non-conjugated。對于wnt8 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA340936LB01XBE wnt8 Antibody, HRP conjugated ELISA
    FITC CSB-PA340936LC01XBE wnt8 Antibody, FITC conjugated
    Biotin CSB-PA340936LD01XBE wnt8 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in ventral mesodermal patterning during embryogenesis. Mimics Nieuwkoop center activity. Causes dorsal mesodermal differentiation of animal cap ectoderm when coexpressed with noggin and nuclear, sequence-specific DNA-binding protein xBra. None of these molecules causes dorsal mesoderm formation when expressed alone.
  • 基因功能參考文獻：
    1. Data show that Noggin4 fine-tune the Wnt8 posterior-to-anterior gradient. PMID: 26973133
    2. EFHC1 domains are involved in ciliary localization, ciliogenesis, and the regulation of Wnt8a signaling PMID: 26783883
    3. Sulf1 inhibits the ability of Wnt8a to activate the canonical Wnt signalling pathway. PMID: 25681501
    4. study presents the structure of Xenopus Wnt8 (XWnt8) in complex with the mouse Fz8-cysteine-rich domain to a resolution of 3.25 A PMID: 22653731
    5. Xwnt8 directly initiates expression of labial Hox genes. PMID: 19623617
    6. Wnt8 conveyed by Frizzled-related proteins can activate canonical Wnt signalling despite the function of Frizzled-related proteins as Wnt inhibitors, suggesting a novel regulatory system for Wnts by sFRPs PMID: 19906850
    7. by performing gain- and loss-of-function of Wnt signaling experiments, we show that this pathway plays an important role not only in neural crest induction but also in the specification of the neural crest competence territory PMID: 14699582
    8. Wnt8 may stimulate a cellular phosphatase to dephosphorylate and activate CKIepsilon PMID: 14722104
    9. Molecular modeling of the complex between the xWNT8 protein and the CRD domain of mFZD8 PMID: 17506343
    10. Xwnt8-mediated posteriorization is restricted to the eye level and is independent of mesoderm formation. PMID: 18318733
    11. Fgf8a induces neural crest (NC) indirectly through the activation of Wnt8 in the paraxial mesoderm, which in turn promotes NC formation in the overlying ectoderm primed by Bmp antagonists. PMID: 18997112

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  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Wnt family
  • 數據庫鏈接：

    KEGG: xla:397970

    UniGene: Xl.49



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