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  4. ZWINT Antibody

ZWINT Antibody

  • 中文名稱：
    ZWINT兔多克隆抗體
  • 貨號：
    CSB-PA527261ESR2HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA527261ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA527261ESR2HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ZWINT Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ZWINT
  • 別名：
    Human ZW10 interacting protein 1 antibody; HZwint 1 antibody; HZwint1 antibody; KNTC 2 AP antibody; KNTC2AP antibody; MGC 117174 antibody; MGC117174 antibody; ZW10 interacting kinetochore protein antibody; ZW10 interacting protein 1 antibody; ZW10 interactor antibody; ZW10 interactor; kinetochore protein antibody; ZW10-interacting protein 1 antibody; ZWINT 1 antibody; ZWINT antibody; Zwint-1 antibody; ZWINT_HUMAN antibody; ZWINT1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ZW10 interactor protein (1-277AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
  • 基因功能參考文獻：
    1. ZW10 interactor was frequently decreased in hepatocellular carcinoma. PMID: 30198401
    2. Our results provide the first evidence that Zwint-1 is required to correct erroneous kinetochore-microtubule attachment and regulate spindle checkpoint function during meiosis. PMID: 26486467
    3. the E3 ubiquitin ligase terf causes protein degradation of ZWINT and negatively regulates cell proliferation PMID: 22023800
    4. These studies identify zwint-1 as a novel AurB substrate required for kinetochore assembly and for proper spindle assembly checkpoint silencing at metaphase PMID: 21775627
    5. hZwint-1 bridges the inner and outer kinetochore: identification of the kinetochore localization domain and the hZw10-interaction domain PMID: 21345172
    6. show that ZW10 interacting protein-1(Zwint-1) is required and is sufficient for kinetochore localization of Zeste White 10 (ZW10) in HeLa cells PMID: 15485811
    7. Stable hZW10 kinetochore residency at prometaphase kinetochores is dependent on its interaction with hZwint-1, and is essential for mitotic checkpoint arrest. PMID: 18268100

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  • 亞細胞定位：
    Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
  • 數據庫鏈接：

    HGNC: 13195

    OMIM: 609177

    KEGG: hsa:11130

    STRING: 9606.ENSP00000363055

    UniGene: Hs.591363



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