在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. WIPI2 Antibody

WIPI2 Antibody

  • 中文名稱：
    WIPI2兔多克隆抗體
  • 貨號：
    CSB-PA026118GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ATG18B antibody; Atg21 antibody; CGI 50 antibody; DKFZp434J154 antibody; DKFZp686P02188 antibody; FLJ12979 antibody; FLJ14217 antibody; FLJ42984 antibody; WD repeat domain phosphoinositide-interacting protein 2 antibody; WD repeat domain; phosphoinositide interacting 2 antibody; WD40 repeat protein interacting with phosphoinositides 2 antibody; WIPI 2 antibody; WIPI-2 antibody; WIPI2 antibody; WIPI2_HUMAN antibody; WIPI49 like protein 2 antibody; WIPI49-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human WIPI2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.; Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
  • 基因功能參考文獻：
    1. Data suggest that, in patients with diabetic kidney disease, urinary excretion of mRNAs for MAP1LC3A, WIPI2, and RB1CC1 is down-regulated as compared to healthy control subjects; these transcripts may serve as urinary autophagy biomarkers. (MAP1LC3A = microtubule associated protein 1 light chain 3; WIPI2 = WD repeat domain phosphoinositide-interacting protein 2; RB1CC1 = RB1 inducible coiled-coil 1) PMID: 28760651
    2. Here the authors show that recruitment of WIPI2, itself essential for anti-bacterial autophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic bacteria. PMID: 27370208
    3. The specific autophagosomal localization of both WIPI1 and WIPI2 (refered to as WIPI puncta) has been employed to assess autophagy using fluorescence microscopy methods, such as confocal and live-cell video microscopy PMID: 25462558
    4. Data suggest WIPI1/WIPI2 co-localize with microtubule-associated light chain 3 and autophagy related proteins 2/14L, participate in biogenesis of phagosomes, autophagy, and mobilization of lipids to/from intracellular droplets. [review-like article] PMID: 25233424
    5. WIPI-1 and WIPI-2 are functionally required in mediating the PI3P signal at the onset of autophagy in NB4 cells. PMID: 24991767
    6. Data suggest that WIPI2b directly interacts with dimer of ATG16L1 (autophagy related 16-like 1) and this interaction is linked to production of phosphatidylinositol 3-phosphate in endoplasmic reticulum triggered by autophagosome formation. [REVIEW] PMID: 25233411
    7. WIPI2b binds the membrane surrounding Salmonella and recruits the Atg12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. PMID: 24954904
    8. A role for WIPI2 in the progression of omegasomes into autophagosomes, is reported. PMID: 20505359
    9. Freeze-fracture replica immunolabelling reveals WD-repeat protein interacting with phosphoinositides 1 and 2 (WIPI-1 and WIPI-2) as membrane components of autophagosomes and the plasma membrane (PM). PMID: 21564513
    10. WIPI2 is a phosphatidylinsitol-3-phosphate binding protein required for starvation induced autophagy. PMID: 20505359

    顯示更多

    收起更多

  • 亞細胞定位：
    Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    WD repeat SVP1 family
  • 組織特異性：
    Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.
  • 數據庫鏈接：

    HGNC: 32225

    OMIM: 609225

    KEGG: hsa:26100

    STRING: 9606.ENSP00000288828

    UniGene: Hs.122363



主站蜘蛛池模板： 中文字幕aⅴ人妻一区二区| 欧美视频专区一二在线观看| 少妇av射精精品蜜桃专区| 一区二区国产精品精华液| 一线二线无人区乱码 | 法国白嫩大屁股xxxx| 国内精品久久久久精免费| 成年片色大黄全免费网站久久高潮| 免费网站观看www在线观看| 久久av无码αv高潮αv喷吹| 亚洲国产无线乱码在线观看| 2017亚洲天堂最新地址| 成年女人看片永久免费视频 | 久久久一本精品久久精品六六| 欧洲熟妇色xxxx欧美老妇软件| 精品国产乱码久久久久久郑州公司| 天天躁日日躁狠狠躁2018| 狠狠色狠狠色狠狠五月| 欧美婷婷六月丁香综合色 | 国产亚洲精品成人aa片新蒲金| 国产老妇伦国产熟女老妇视频| 久久超碰色中文字幕超清| 老男人久久青草av高清| 久久亚洲国产成人精品无码区| 国产三级久久久精品麻豆三级| 综合无码成人aⅴ视频在线观看| 97狠狠狠狼鲁亚洲综合网| 国产精品爽爽久久久久久蜜臀| 人妻丝袜av中文系列先锋影音| 韩国午夜福利片在线| 国产成人无码一区二区在线播放| 国产成人精品午夜福利| 亚洲韩国日本高清一区| 暴力强奷在线播放无码| 少妇私密会所按摩到高潮呻吟| 无码国产午夜福利片在线观看| 日韩无套内射高潮| 国产freexxxx性播放麻豆| 国产精品不卡无码av在线播放| 欧美丰满大乳高跟鞋| 日本成本人片免费网站|