在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. WIPI2 Antibody

WIPI2 Antibody

  • 中文名稱：
    WIPI2兔多克隆抗體
  • 貨號：
    CSB-PA531726
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Human Skeletal Muslce Tissue using WIPI2 Rabbit pAb diluted at 1:200
    • Immunohistochemical analysis of paraffin-embedded Human Breast Carcinoma Tissue using WIPI2 Rabbit pAb diluted at 1:200
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ATG18B antibody; Atg21 antibody; CGI 50 antibody; DKFZp434J154 antibody; DKFZp686P02188 antibody; FLJ12979 antibody; FLJ14217 antibody; FLJ42984 antibody; WD repeat domain phosphoinositide-interacting protein 2 antibody; WD repeat domain; phosphoinositide interacting 2 antibody; WD40 repeat protein interacting with phosphoinositides 2 antibody; WIPI 2 antibody; WIPI-2 antibody; WIPI2 antibody; WIPI2_HUMAN antibody; WIPI49 like protein 2 antibody; WIPI49-like protein 2 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Recombinant Protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:50-1:200
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.; Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes and preautophagosomal structures, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Isoform 4 is also required for autophagic clearance of pathogenic bacteria. Isoform 4 binds the membrane surrounding Salmonella and recruits the ATG12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella.
  • 基因功能參考文獻(xiàn)：
    1. Data suggest that, in patients with diabetic kidney disease, urinary excretion of mRNAs for MAP1LC3A, WIPI2, and RB1CC1 is down-regulated as compared to healthy control subjects; these transcripts may serve as urinary autophagy biomarkers. (MAP1LC3A = microtubule associated protein 1 light chain 3; WIPI2 = WD repeat domain phosphoinositide-interacting protein 2; RB1CC1 = RB1 inducible coiled-coil 1) PMID: 28760651
    2. Here the authors show that recruitment of WIPI2, itself essential for anti-bacterial autophagy, is dependent on the localization of catalytically active TBK1 to the vicinity of cytosolic bacteria. PMID: 27370208
    3. The specific autophagosomal localization of both WIPI1 and WIPI2 (refered to as WIPI puncta) has been employed to assess autophagy using fluorescence microscopy methods, such as confocal and live-cell video microscopy PMID: 25462558
    4. Data suggest WIPI1/WIPI2 co-localize with microtubule-associated light chain 3 and autophagy related proteins 2/14L, participate in biogenesis of phagosomes, autophagy, and mobilization of lipids to/from intracellular droplets. [review-like article] PMID: 25233424
    5. WIPI-1 and WIPI-2 are functionally required in mediating the PI3P signal at the onset of autophagy in NB4 cells. PMID: 24991767
    6. Data suggest that WIPI2b directly interacts with dimer of ATG16L1 (autophagy related 16-like 1) and this interaction is linked to production of phosphatidylinositol 3-phosphate in endoplasmic reticulum triggered by autophagosome formation. [REVIEW] PMID: 25233411
    7. WIPI2b binds the membrane surrounding Salmonella and recruits the Atg12-5-16L1 complex, initiating LC3 conjugation, autophagosomal membrane formation, and engulfment of Salmonella. PMID: 24954904
    8. A role for WIPI2 in the progression of omegasomes into autophagosomes, is reported. PMID: 20505359
    9. Freeze-fracture replica immunolabelling reveals WD-repeat protein interacting with phosphoinositides 1 and 2 (WIPI-1 and WIPI-2) as membrane components of autophagosomes and the plasma membrane (PM). PMID: 21564513
    10. WIPI2 is a phosphatidylinsitol-3-phosphate binding protein required for starvation induced autophagy. PMID: 20505359

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Preautophagosomal structure membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    WD repeat SVP1 family
  • 組織特異性：
    Ubiquitously expressed (at protein level). Highly expressed in heart, skeletal muscle and pancreas. Expression is down-regulated in pancreatic and in kidney tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 32225

    OMIM: 609225

    KEGG: hsa:26100

    STRING: 9606.ENSP00000288828

    UniGene: Hs.122363



主站蜘蛛池模板： 久久五十路丰满熟女中出| 五月开心播播网| 妺妺窝人体色www在线| av高清无码 在线播放| 精品伊人久久久大香线蕉下载| 久久久久久久久蜜桃| 男女裸交免费无遮挡全过程| 亚洲成a∨人片在无码2023| 久久这里只有是精品23| 无码办公室丝袜ol中文字幕| r级无码视频在线观看| 特黄做受又粗又长又大又硬| 欲女熟妇国产一区二区| www夜插内射视频网站| 免费大黄网站| 无码中字出轨中文人妻中文中 | 宝贝腿开大点我添添公视频免费| 国产成人无码a区精油按摩| 成人h动漫精品一区二区| 亚洲精品无码久久毛片波多野吉衣| 国产卡一卡二无线乱码| 欧美老熟妇xb水多毛多| av无码东京热亚洲男人的天堂| 亚洲一卡2卡三卡4卡无卡下载| 长腿校花无力呻吟娇喘的视频| 国产偷人妻精品一区| 欧洲无码精品a码无人区| 97av麻豆蜜桃一区二区| 国产午夜精品一区理论片飘花| 青青青国产免a在线观看| 久久久国产精品无码一区二区| 在教室伦流澡到高潮hgl视频| 高清无码午夜福利视频| 久久九九兔免费精品6| 男人边吃奶边做好爽免费视频| 国产黄大片在线观看画质优化| 久久综合九色综合97网| 久久国产精品老女人| 免费国产黄网站在线观看| 欧美日韩不卡视频合集| 人妻换着玩又刺激又爽|