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WDR34 Antibody

  • 中文名稱:
    WDR34兔多克隆抗體
  • 貨號:
    CSB-PA842668LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: WDR34 antibody at 1.5µg/ml
      Lane 1: PC-3 whole cell lysate
      Lane 2: MDA-MB-231 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 58 kDa
      Observed band size: 58 kDa
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA842668LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) WDR34 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    WDR34
  • 別名:
    bA216B9.3 antibody; DIC5 antibody; MGC20486 antibody; OTTHUMP00000022282 antibody; RP11 216B9.5 antibody; WD repeat containing protein 34 antibody; WD repeat domain 34 antibody; WD repeat-containing protein 34 antibody; WDR 34 antibody; Wdr34 antibody; WDR34_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human WD repeat-containing protein 34 protein (1-210AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,WDR34 Antibody (CSB-PA842668LA01HU),的標記方式是Non-conjugated。對于WDR34 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA842668LB01HU WDR34 Antibody, HRP conjugated ELISA
    FITC CSB-PA842668LC01HU WDR34 Antibody, FITC conjugated
    Biotin CSB-PA842668LD01HU WDR34 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone.; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
  • 基因功能參考文獻:
    1. In addition to the in vitro experiments, WDR34 negativity was correlated with tumoral growth of OSCCs. Our findings suggested that WDR34 inhibits OSCC progression and might be a potential tumor-suppressor molecule in OSCCs. PMID: 29278705
    2. In patients with short-rib polydactyly syndrome type III, primary cilia in WDR34 mutant fibroblasts were significantly shorter than normal and had a bulbous tip. PMID: 24183449
    3. Mutations in WDR34 cause Jeune asphyxiating thoracic dystrophy. WDR34 is critical for ciliary functions essential to normal development and survival. PMID: 24183451
    4. Results suggest that WDR34 is a TAK1-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. PMID: 19521662
  • 相關疾病:
    Short-rib thoracic dysplasia 11 with or without polydactyly (SRTD11)
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cell projection, filopodium.
  • 組織特異性:
    Expressed in several cell lines (at protein level).
  • 數據庫鏈接:

    HGNC: 28296

    OMIM: 613363

    KEGG: hsa:89891

    STRING: 9606.ENSP00000361800

    UniGene: Hs.495240



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