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  4. WDR34 Antibody, HRP conjugated

WDR34 Antibody, HRP conjugated

  • 中文名稱：
    WDR34兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA842668LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) WDR34 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    WDR34
  • 別名：
    bA216B9.3 antibody; DIC5 antibody; MGC20486 antibody; OTTHUMP00000022282 antibody; RP11 216B9.5 antibody; WD repeat containing protein 34 antibody; WD repeat domain 34 antibody; WD repeat-containing protein 34 antibody; WDR 34 antibody; Wdr34 antibody; WDR34_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human WD repeat-containing protein 34 protein (1-210AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis. Required also to maintain a functional transition zone.; Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation.
  • 基因功能參考文獻：
    1. In addition to the in vitro experiments, WDR34 negativity was correlated with tumoral growth of OSCCs. Our findings suggested that WDR34 inhibits OSCC progression and might be a potential tumor-suppressor molecule in OSCCs. PMID: 29278705
    2. In patients with short-rib polydactyly syndrome type III, primary cilia in WDR34 mutant fibroblasts were significantly shorter than normal and had a bulbous tip. PMID: 24183449
    3. Mutations in WDR34 cause Jeune asphyxiating thoracic dystrophy. WDR34 is critical for ciliary functions essential to normal development and survival. PMID: 24183451
    4. Results suggest that WDR34 is a TAK1-associated inhibitor of the IL-1R/TLR3/TLR4-induced NF-kappaB activation pathway. PMID: 19521662
  • 相關疾病：
    Short-rib thoracic dysplasia 11 with or without polydactyly (SRTD11)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium. Cell projection, filopodium.
  • 組織特異性：
    Expressed in several cell lines (at protein level).
  • 數據庫鏈接：

    HGNC: 28296

    OMIM: 613363

    KEGG: hsa:89891

    STRING: 9606.ENSP00000361800

    UniGene: Hs.495240



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