在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VPS39 Antibody, HRP conjugated

  • 中文名稱:
    VPS39兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA836235LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VPS39 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    A230065P22Rik antibody; AW743070 antibody; FLJ21681 antibody; FLJ46546 antibody; hVam6p antibody; KIAA0770 antibody; RP23-348L16.12 antibody; TLP antibody; TRAP1 like protein antibody; Vacuolar protein sorting 39 antibody; Vacuolar protein sorting 39 homolog antibody; VAM6 antibody; Vam6/Vps39 like antibody; Vam6/Vps39 like protein antibody; Vam6/Vps39-like protein antibody; VPS 39 antibody; Vps39 antibody; VPS39_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Vam6/Vps39-like protein (263-490AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation.; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes. Required for fusion of endosomes and autophagosomes with lysosomes.
  • 基因功能參考文獻:
    1. TLP expression contributes to hypertrophic scar formation and contraction. PMID: 25655281
    2. TLP likely acts as a molecular modulator capable of altering the balance of Smad3- and Smad2-dependent signaling through regulation of phosphorylation, thus facilitating collagen synthesis in fibroblasts. PMID: 23418473
    3. Vps39 knockdown impairs late endosome fusion and fusion between late endosomes and lysosomes. PMID: 23167963
    4. Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus PMID: 21454559
    5. although only TBC1D15/Rab7-GAP altered Rab7-GTP levels, both Rab7-GAP and mVps39 regulate lysosomal morphology and play a role in maintaining growth factor dependence PMID: 20363736
    6. propose that TLP might regulate the balance of Smad2 and Smad3 signaling by localizing Smad4 intracellularly, thus contributing to cellular specificity of TGF-beta transcriptional responses in both normal and pathophysiology PMID: 12941698

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Lysosome membrane; Peripheral membrane protein. Late endosome membrane; Peripheral membrane protein.;
  • 蛋白家族:
    VAM6/VPS39 family
  • 組織特異性:
    Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen.
  • 數據庫鏈接:

    HGNC: 20593

    OMIM: 612188

    KEGG: hsa:23339

    STRING: 9606.ENSP00000326534

    UniGene: Hs.88025



主站蜘蛛池模板: 无码专区一va亚洲v专区在线| 国产+成+人+亚洲欧洲自线| 免费国产va在线观看中文字| 欧美高潮喷水大叫| 精品免费国偷自产在线视频| 欧美人禽杂交狂配| 日日躁夜夜躁白天躁晚上| 国产精品久久无码不卡| 久久久国产精品无码一区二区 | 乱人伦视频中文字幕| 国产精品偷伦视频观看免费 | 成人av无码国产在线观看| 日本大尺度吃奶呻吟视频| 亚洲欧美中文日韩在线视频一| 国产无套水多在线观看| 欧美无人区码suv| 成人性生交片无码免费看| 麻豆国产在线精品国偷产拍| 亚洲成av人片高潮喷水| 浪潮av激情高潮国产精品| 少妇高潮毛片色欲ava片 | 免费无码作爱视频| 国产午夜精品久久久久免费视| 欧美亚洲色综久久精品国产| 2021国产精品视频网站| 国语少妇高潮对白在线| 国产成年无码久久久久下载| 久久久无码人妻精品无码| 成人无码视频97免费| 早起邻居人妻奶罩太松av| 国产高清av首播原创麻豆| 手机看片国产av无码| 国产精品无码翘臀在线看| 无码粉嫩虎白一线天在线观看| 国产又色又爽又黄好看的视频| 午夜福利不卡片在线机免费视频 | 中文字幕人妻被公上司喝醉在线 | 亚洲 另类 在线 欧美 制服| 日本免费高清一本视频| 一区二区三区无码被窝影院| 无码h黄动漫在线播放网站|