在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VPS33A Antibody

  • 中文名稱:
    VPS33A兔多克隆抗體
  • 貨號:
    CSB-PA128038
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA128038(VPS33A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA128038(VPS33A Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    VPS33A
  • 別名:
    VPS33AVacuolar protein sorting-associated protein 33A antibody; hVPS33A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human VPS33A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
  • 基因功能參考文獻:
    1. Mutations in VPS33A is associated with mucopolysaccharidosis with severe systemic symptoms. PMID: 28013294
    2. The clinical phenotype and genetic studies support the suggestion that the siblings most probably have a novel disease very likely caused by a VPS33A gene defect. PMID: 27547915
    3. association of VPS33A with HOPS via its interaction with VPS16 is required for both endosome- and autophagosome-lysosome fusion PMID: 25783203
    4. Melanoma cells depleted of vacuolar protein sorting 33A protein have increased nuclear localization of cis-diaminedichloroplatinum II, increased nuclear DNA damage by platination, and increased apoptosis, resulting in increased treatment sensitivity. PMID: 22203954
    5. VPS33A is mutated in Hermansky-Pudlak syndrome and may have a role in melanogenesis PMID: 12538872
    6. A and B classes reflect the evolution of organelle/tissue-specific functions PMID: 15790593

    顯示更多

    收起更多

  • 相關疾病:
    Mucopolysaccharidosis-plus syndrome (MPSPS)
  • 亞細胞定位:
    Cytoplasmic vesicle. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
  • 蛋白家族:
    STXBP/unc-18/SEC1 family
  • 數據庫鏈接:

    HGNC: 18179

    OMIM: 610034

    KEGG: hsa:65082

    STRING: 9606.ENSP00000267199

    UniGene: Hs.487883



主站蜘蛛池模板: 日本乱子伦一区二区三区| 亚洲另类欧美在线电影| 国产av亚洲精品久久久久久小说| 亚洲一区av无码专区在线观看| 疯狂撞击丝袜人妻| 久久精品亚洲成在人线av麻豆| 欧美成人精品午夜免费影视| 国产精品免费久久久久电影| 一个人看的www免费视频在线观看| 免费刺激性视频大片区| 国产传媒麻豆剧精品av| 中文字幕精品一区二区2021年| 色依依av在线| 色一情一伦一区二区三| 一区二区三区国产精华液| 天天av天天翘天天综合网| 色翁荡息又大又硬又粗又爽| 亚洲综合av一区二区三区不卡| 色av专区无码影音先锋| 精品久久人人爽天天玩人人妻| 久青草无码视频在线观看| 亚洲色欲色欲天天天www| 一本加勒比hezyo无码专区| 99国产精品国产精品九九| 人与人性恔配视频免费| 五月激情婷婷丁香综合基地| 国产成人一区二区三区| 中国熟妇牲交视频| 精品久久久无码中文字幕一丶| 成人午夜福利视频| 女人张开腿让男桶喷水高潮| 国产aⅴ精品一区二区三区久久| 亚洲国产无套无码av电影| 国产看黄网站又黄又爽又色| 丝袜美腿丝袜亚洲综合| 国产午夜福利小视频合集| 1000部啪啪未满十八勿入| av中文字幕潮喷人妻系列| 国产乱子伦三级在线播放| 免费国产黄网站在线观看可以下载| 国产一区二区三区美女|