在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VPS33A Antibody, Biotin conjugated

  • 中文名稱:
    VPS33A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA850260LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VPS33A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    VPS33A
  • 別名:
    VPS33AVacuolar protein sorting-associated protein 33A antibody; hVPS33A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Vacuolar protein sorting-associated protein 33A protein (1-300AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Required for fusion of endosomes and autophagosomes with lysosomes; the function is dependent on its association with VPS16 but not VIPAS39. The function in autophagosome-lysosome fusion implicates STX17 but not UVRAG.
  • 基因功能參考文獻:
    1. Mutations in VPS33A is associated with mucopolysaccharidosis with severe systemic symptoms. PMID: 28013294
    2. The clinical phenotype and genetic studies support the suggestion that the siblings most probably have a novel disease very likely caused by a VPS33A gene defect. PMID: 27547915
    3. association of VPS33A with HOPS via its interaction with VPS16 is required for both endosome- and autophagosome-lysosome fusion PMID: 25783203
    4. Melanoma cells depleted of vacuolar protein sorting 33A protein have increased nuclear localization of cis-diaminedichloroplatinum II, increased nuclear DNA damage by platination, and increased apoptosis, resulting in increased treatment sensitivity. PMID: 22203954
    5. VPS33A is mutated in Hermansky-Pudlak syndrome and may have a role in melanogenesis PMID: 12538872
    6. A and B classes reflect the evolution of organelle/tissue-specific functions PMID: 15790593

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Mucopolysaccharidosis-plus syndrome (MPSPS)
  • 亞細胞定位:
    Cytoplasmic vesicle. Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Lysosome membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Cytoplasmic vesicle, autophagosome. Cytoplasmic vesicle, clathrin-coated vesicle.
  • 蛋白家族:
    STXBP/unc-18/SEC1 family
  • 數據庫鏈接:

    HGNC: 18179

    OMIM: 610034

    KEGG: hsa:65082

    STRING: 9606.ENSP00000267199

    UniGene: Hs.487883



主站蜘蛛池模板: 欧洲精品成人免费视频在线观看| 国产精品最新免费视频| 亚洲国产超清无码专区| 久久精品日韩av无码| 影音先锋女人av鲁色资源网久久| 亚洲色成人一区二区三区小说| 国产无遮挡又黄又爽在线视频| 2020国产成人精品影视| 精品久久久无码中文字幕 | 国产边打电话边被躁视频| 狼色精品人妻在线视频| 成人av无码一区二区三区| 92久久精品一区二区| 成年日韩片av在线网站| 亚洲色欲av无码成人专区| а天堂中文在线官网在线| 精品少妇无码av无码专区| 亚无码乱人伦一区二区| 国产精品国产三级国产剧情| 色偷偷色噜噜狠狠网站年轻人| 人妻丰满熟妇av无码区免| 9420免费高清在线观看视频 | 色777狠狠狠综合| 国内精品久久久久影院日本| 天堂√最新版中文在线地址| 亚洲另类欧美综合在线| 色琪琪丁香婷婷综合久久| 啦啦啦www在线观看免费视频| 少妇愉情理伦片丰满丰满午夜 | 国产精品乱码一区二区三| 国产99视频精品专区| 欧美日韩精品一区二区性色a+v| 青青草大香焦在线综合视频| 99久久久无码国产精品秋霞网| 中文字幕一区二区精品区| 野外亲子乱子伦视频丶| 国产欧美一区二区三区在线看| 女同性av片在线观看免费网站| 国产强伦姧在线观看无码| 亚洲丰满熟女一区二区v| 无码国内精品人妻少妇|