在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. VPS29 Antibody, HRP conjugated

VPS29 Antibody, HRP conjugated

  • 中文名稱：
    VPS29兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA890661LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) VPS29 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DC15 antibody; DC7 antibody; DKFZp564F0223 antibody; FLJ20492 antibody; hVPS29 antibody; PEP11 antibody; PEP11 homolog antibody; Retromer protein antibody; Vacuolar protein sorting 29 antibody; Vacuolar protein sorting 29 (yeast homolog) antibody; Vacuolar protein sorting 29 (yeast) antibody; Vacuolar protein sorting 29 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 29 homolog antibody; Vacuolar protein sorting associated protein 29 antibody; Vacuolar protein sorting-associated protein 29 antibody; Vacuolar sorting protein VPS29/PEP11 antibody; Vesicle protein sorting 29 antibody; VPS 29 antibody; VPS29 antibody; VPS29 retromer complex component antibody; VPS29_HUMAN antibody; x 007 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Vacuolar protein sorting-associated protein 29 protein (68-145AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27.; (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus.
  • 基因功能參考文獻：
    1. RidL is critical for binding of the L. pneumophila effector to the Vps29 retromer subunit and displacement of the regulator TBC1D5. PMID: 29146912
    2. The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins - Vps26, Vps29 and Vps35, which are impaired in neurodegenerative diseases. (Review) PMID: 26965691
    3. This study demonstrated that Genetic variability of VPS29 in parkinsonism. PMID: 25475142
    4. Data indicate that vesicular transport proteins VPS35 and VPS29 influence the levels of the other subunit of retromer. PMID: 25937119
    5. Mutations in the gene composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease. PMID: 24684791
    6. Conclusion is that VPS29 is a metal ion-independent, rigid scaffolding domain, which is essential but not sufficient for incorporation of retromer into functional endosomal transport assemblies. PMID: 21629666
    7. analysis of the phosphodiesterase/nuclease-like fold and two protein-protein interaction sites in human VPS29 PMID: 15788412
    8. It was demonstrated that recombinant human Vps29 displays in vitro phosphatase activity towards a serine-phosphorylated peptide, containing the acidic-cluster dileucine motif of the cytoplasmatic tail of the CI-M6PR. PMID: 16737443
    9. These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26-Vps29-Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles. PMID: 17101778
    10. crystal structure of a VPS29-VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 acts as a scaffold for the carboxy-terminal half of VPS35 PMID: 17891154
    11. Membrane recruitment of the cargo-selective retromer subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. PMID: 19531583

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome. Late endosome.
  • 蛋白家族：
    VPS29 family
  • 組織特異性：
    Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.
  • 數據庫鏈接：

    HGNC: 14340

    OMIM: 606932

    KEGG: hsa:51699

    STRING: 9606.ENSP00000380795

    UniGene: Hs.600114



主站蜘蛛池模板： 精品久久久久久国产潘金莲| 最近中文字幕mv在线资源| 欧美性猛交xxxx乱大交丰满| 亚 洲 成 人 网站在线观看| 成人特级毛片www免费版| 精品丰满人妻无套内射| 国产伦精品一区二区三区| 毛片完整版的免费观看| 国产女厕所盗摄老师厕所嘘嘘| 少妇仑乱a毛片| 一二三四在线视频观看社区| 男阳茎进女阳道视频大全| 国产乱人伦av在线a更新| 成人性欧美丨区二区三区| 国内精品久久人妻互换| 国产色xx群视频射精| 欧美 国产日韩 综合在线| 日韩av中文无码影院| 精品一区二区三区在线视频 | 2020精品国产自在现线官网| 再深点灬舒服灬太大了网站| 强行交换配乱婬bd| 97se狠狠狠狠狼鲁亚洲综合色| 国产亚洲欧洲aⅴ综合一区| 少妇人妻偷人精品视蜜桃| 青草内射中出高潮| 天天躁久久躁日日躁| 女厕厕露p撒尿八个少妇| 国产精品ⅴ无码大片在线看| 欧美成 人版中文字幕| 2021无码天堂在线| 亚洲成a人片在线观看无码| 丰满爆乳无码一区二区三区| 日日碰狠狠躁久久躁96| 日韩视频 中文字幕 视频一区 | 少妇高潮喷潮久久久影院| 在线亚洲综合欧美网站首页| 亚洲hdmi高清线| 九九久久精品国产av片国产| 久久久亚洲精品无码| 国产熟妇人妻精品一区二区动漫|