在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. VPS29 Antibody, Biotin conjugated

VPS29 Antibody, Biotin conjugated

  • 中文名稱：
    VPS29兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA890661LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) VPS29 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    DC15 antibody; DC7 antibody; DKFZp564F0223 antibody; FLJ20492 antibody; hVPS29 antibody; PEP11 antibody; PEP11 homolog antibody; Retromer protein antibody; Vacuolar protein sorting 29 antibody; Vacuolar protein sorting 29 (yeast homolog) antibody; Vacuolar protein sorting 29 (yeast) antibody; Vacuolar protein sorting 29 homolog (S. cerevisiae) antibody; Vacuolar protein sorting 29 homolog antibody; Vacuolar protein sorting associated protein 29 antibody; Vacuolar protein sorting-associated protein 29 antibody; Vacuolar sorting protein VPS29/PEP11 antibody; Vesicle protein sorting 29 antibody; VPS 29 antibody; VPS29 antibody; VPS29 retromer complex component antibody; VPS29_HUMAN antibody; x 007 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Vacuolar protein sorting-associated protein 29 protein (68-145AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling. The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes. Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27.; (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus.
  • 基因功能參考文獻：
    1. RidL is critical for binding of the L. pneumophila effector to the Vps29 retromer subunit and displacement of the regulator TBC1D5. PMID: 29146912
    2. The retromer complex is a highly conserved membrane trafficking assembly composed of three proteins - Vps26, Vps29 and Vps35, which are impaired in neurodegenerative diseases. (Review) PMID: 26965691
    3. This study demonstrated that Genetic variability of VPS29 in parkinsonism. PMID: 25475142
    4. Data indicate that vesicular transport proteins VPS35 and VPS29 influence the levels of the other subunit of retromer. PMID: 25937119
    5. Mutations in the gene composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease. PMID: 24684791
    6. Conclusion is that VPS29 is a metal ion-independent, rigid scaffolding domain, which is essential but not sufficient for incorporation of retromer into functional endosomal transport assemblies. PMID: 21629666
    7. analysis of the phosphodiesterase/nuclease-like fold and two protein-protein interaction sites in human VPS29 PMID: 15788412
    8. It was demonstrated that recombinant human Vps29 displays in vitro phosphatase activity towards a serine-phosphorylated peptide, containing the acidic-cluster dileucine motif of the cytoplasmatic tail of the CI-M6PR. PMID: 16737443
    9. These observations indicate that the mammalian retromer complex assembles by sequential association of SNX1/2 and Vps26-Vps29-Vps35 subcomplexes on endosomal membranes and that SNX1 and SNX2 play interchangeable but essential roles. PMID: 17101778
    10. crystal structure of a VPS29-VPS35 subcomplex showing how the metallophosphoesterase-fold subunit VPS29 acts as a scaffold for the carboxy-terminal half of VPS35 PMID: 17891154
    11. Membrane recruitment of the cargo-selective retromer subcomplex VPS35/29/26 is catalysed by the small GTPase Rab7 and inhibited by the Rab-GAP TBC1D5. PMID: 19531583

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. Early endosome. Late endosome.
  • 蛋白家族：
    VPS29 family
  • 組織特異性：
    Ubiquitous. Highly expressed in heart, lung, placenta, spleen, peripheral blood leukocytes, thymus, colon skeletal muscle, kidney and brain.
  • 數據庫鏈接：

    HGNC: 14340

    OMIM: 606932

    KEGG: hsa:51699

    STRING: 9606.ENSP00000380795

    UniGene: Hs.600114



主站蜘蛛池模板： 五月丁香综合缴情六月小说| 国产精品美女久久久久久久久| 少妇人妻偷人精品一区二区| 欧美 亚洲 国产 日韩 综aⅴ | 国产影片中文字幕| 国产高潮流白浆免费观看| 内射一区二区精品视频在线观看 | 中文字幕无码热在线视频| 无码中文字幕av免费放dvd| 亚洲精品高清无码视频| 香港三级日本三级a视频| 青青青国产在线观看免费| 天天躁夜夜躁狠狠躁2021a2| 国产成人精品123区免费视频| 尤物网址在线观看| 免费无码又爽又刺激软件下载| 亚洲精品亚洲人成在线下载| 爱做久久久久久| 玩弄漂亮少妇高潮白浆 | 国产黑色丝袜在线看片不卡顿| 高中生自慰www网站| 成年午夜性影院免费观看 | 不卡av电影在线| 亚洲综合av色婷婷| 18禁止午夜福利体验区| 免费特级黄毛片| 久久精品国产精品青草| 日本高清va在线播放| 国产精品麻豆成人av电影艾秋| 亚洲啪av永久无码精品放毛片| 国产高潮抽搐喷水高清| 一本一本久久a久久综合精品 | 人妻体内射精一区二区三区| 亚洲无线观看国产精品| 国产内射一区亚洲| 国产一区日韩二区欧美三区| 精品人妻系列无码人妻不卡| 在线看片免费人成视频影院看| 国产内射爽爽大片| 国产成人精品一区二区3| 中文字幕aav|