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  4. VOPP1 Antibody, Biotin conjugated

VOPP1 Antibody, Biotin conjugated

  • 中文名稱：
    VOPP1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA03545D0Rb
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) VOPP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    VOPP1
  • 別名：
    VOPP1 antibody; ECOP antibody; GASP antibody; Vesicular antibody; overexpressed in cancer antibody; prosurvival protein 1 antibody; EGFR-coamplified and overexpressed protein antibody; ECop antibody; Glioblastoma-amplified secreted protein antibody; Putative NF-kappa-B-activating protein 055N antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Vesicular, overexpressed in cancer, prosurvival protein 1 protein (23-172AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
  • 基因功能參考文獻：
    1. miR-218 inhibits human lung adenocarcinoma cell migration and invasion via the suppression of Ecop and Robo1 expression PMID: 28936884
    2. Candidate gene eQTL showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene, previously linked to altered BB response, and high expression of VOPP1. PMID: 26860460
    3. VOPP1 is overexpressed in gastric adenocarcinoma, which is involved in promoting cell proliferation and migration and thus might serve as a putative oncogene. PMID: 25398664
    4. Upregulation of ECOP is associated with glioma. PMID: 23243056
    5. overexpression in cancer participates in the control of the intracellular redox state; its loss leads to oxidative cellular injury leading to cell death by the intrinsic apoptotic pathway PMID: 21519330
    6. ECOP was used as a molecular marker in patients with chronic wounds to guide surgical debridement. PMID: 17515955
    7. Results identify ECOP as a protein relevant to the biology of SCC. PMID: 19525979

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  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.
  • 蛋白家族：
    VOPP1/ECOP family
  • 組織特異性：
    Widely expressed with highest levels in thymus and ovary.
  • 數據庫鏈接：

    HGNC: 34518

    OMIM: 611915

    KEGG: hsa:81552

    STRING: 9606.ENSP00000285279

    UniGene: Hs.488307



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