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  4. Recombinant Human Vesicular, overexpressed in cancer, prosurvival protein 1 (VOPP1), partial

Recombinant Human Vesicular, overexpressed in cancer, prosurvival protein 1 (VOPP1), partial

  • 中文名稱：
    人VOPP1重組蛋白
  • 貨號：
    CSB-YP836183HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人VOPP1重組蛋白
  • 貨號：
    CSB-EP836183HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人VOPP1重組蛋白
  • 貨號：
    CSB-EP836183HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人VOPP1重組蛋白
  • 貨號：
    CSB-BP836183HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人VOPP1重組蛋白
  • 貨號：
    CSB-MP836183HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    VOPP1
  • Uniprot No.：
  • 別名：
    VOPP1; ECOP; GASP; Vesicular; overexpressed in cancer; prosurvival protein 1; EGFR-coamplified and overexpressed protein; ECop; Glioblastoma-amplified secreted protein; Putative NF-kappa-B-activating protein 055N
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.
  • 基因功能參考文獻：
    1. miR-218 inhibits human lung adenocarcinoma cell migration and invasion via the suppression of Ecop and Robo1 expression PMID: 28936884
    2. Candidate gene eQTL showed a trans-acting association between variants of G protein-coupled receptor kinase 5 gene, previously linked to altered BB response, and high expression of VOPP1. PMID: 26860460
    3. VOPP1 is overexpressed in gastric adenocarcinoma, which is involved in promoting cell proliferation and migration and thus might serve as a putative oncogene. PMID: 25398664
    4. Upregulation of ECOP is associated with glioma. PMID: 23243056
    5. overexpression in cancer participates in the control of the intracellular redox state; its loss leads to oxidative cellular injury leading to cell death by the intrinsic apoptotic pathway PMID: 21519330
    6. ECOP was used as a molecular marker in patients with chronic wounds to guide surgical debridement. PMID: 17515955
    7. Results identify ECOP as a protein relevant to the biology of SCC. PMID: 19525979

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  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Note=When overexpressed, localizes in the nucleus and perinuclear regions.
  • 蛋白家族：
    VOPP1/ECOP family
  • 組織特異性：
    Widely expressed with highest levels in thymus and ovary.
  • 數據庫鏈接：

    HGNC: 34518

    OMIM: 611915

    KEGG: hsa:81552

    STRING: 9606.ENSP00000285279

    UniGene: Hs.488307



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