在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VGF Antibody

  • 中文名稱:
    VGF兔多克隆抗體
  • 貨號:
    CSB-PA060065
  • 規(guī)格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    NERP-1 antibody; NERP-2 antibody; Nerve growth factor inducible antibody; Neuroendocrine regulatory peptide-2 antibody; Neurosecretory protein VGF antibody; VGF antibody; VGF_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human VGF.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain.; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons. Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying.; Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis. Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes. Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity.; Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation. Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization.; Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.
  • 基因功能參考文獻:
    1. Results show that VGF is epigenetically modified in human non-small-cell lung cancer (NSCLC) tissues if compared to tumor-free lung tissues, which results in an increased transcription and protein expression. PMID: 29209432
    2. results suggest VGF enhances dendritic maturation and that these effects can be altered by common SNPs in the VGF gene PMID: 28287464
    3. We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity. PMID: 27088090
    4. Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels. PMID: 26337083
    5. Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma. PMID: 26562304
    6. Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls. PMID: 26142708
    7. Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element PMID: 25569790
    8. NERPs may be potent endogenous suppressors of glucose-dependent insulin secretion. PMID: 25529453
    9. DISC1 knockdown leads to a reduction of VGF in neurons. PMID: 24934694
    10. Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance. PMID: 25675362
    11. We conclude that VGF contributes to survival and function of peripheral T cells PMID: 25013207
    12. Among the 19 genes tested, VGF was found to be completely methylated in several Urothelial Cell Carcinoma cell lines PMID: 24830820
    13. The expression of NPY and VGF was increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius in the brains of type-II diabetic patients. PMID: 22808091
    14. [review] The vgf gene is induced in vivo by neurotrophins including nerve growth factor (NGF), brain derived growth factor (BDNF) and glial derived growth actor (GDNF), by synaptic activity and by homeostatic and other stimuli. PMID: 21621608
    15. VGF is regulated by SOD1 and plays a critical role in motor neuron survival PMID: 21151573
    16. localization of neuroendocrine regulatory peptide-1 and-2 (NERP-1 and NERP-2); results suggest that neuroendocrine NERP-1 and NERP-2 might function as local modulatorsin the neuroendocrine system PMID: 20471433
    17. VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann's area 9 of the prefrontal cortex. PMID: 20631166
    18. VGF mRNA levels were significantly reduced in drug-free depressed patients, as compared with controls, and were modulated in response to effective antidepressant treatment. PMID: 20164831
    19. Application of neurosecretory protein VGF biomarker model to current diagnostic criteria provides an objective biomarker pattern that identifies patients with amyotrophic lateral sclerosis. PMID: 16481598
    20. proVGF-related peptides are present in endocrine cells early during development and adulthood and increase in hyperplasia and tumors PMID: 17440014
    21. while Vgf may be a reliable biomarker of progression of muscle weakness in patients with ALS, restoration of Vgf expression in spinal cord motor neurons may therapeutically rescue spinal cord motorneurons against excitotoxic injury PMID: 18432310

    顯示更多

    收起更多

  • 亞細胞定位:
    [Neurosecretory protein VGF]: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
  • 組織特異性:
    Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
  • 數據庫鏈接:

    HGNC: 12684

    OMIM: 602186

    KEGG: hsa:7425

    STRING: 9606.ENSP00000249330

    UniGene: Hs.587325



主站蜘蛛池模板: 亚洲日本乱码中文在线电影| 久久99久久99精品中文字幕| 成 人 色综合 综合网站| 欧美激烈精交gif动态图| 少妇高潮喷水惨叫久久久久电影| 亚洲精品成人网线在线播放va| 内射小寡妇无码| 国内极度色诱视频网站| 亚洲熟妇无码av在线播放| 野狼第一精品社区| 久久青青草原精品国产app| 国产99爱在线视频免费观看| 亚洲精品乱码久久久久久久久久久久 | 国产乱人伦app精品久久| 亚洲最大成人网色| 狠狠色老熟妇老熟女| 亚洲人成欧美中文字幕| 男人一边吃奶一边做爰免费视频| 久久精品国产99国产精偷| 国产成人精品一区二区视频| 久久国产精品_国产精品| 大地资源在线播放观看mv| 亚洲欧洲日韩极速播放| 国产午夜无码片在线观看网站| 色欲久久久中文字幕综合网| 爱做久久久久久| 免费看又黄又爽又猛的视频软件| 日本熟妇hdsex视频| 熟妇高潮一区二区三区| 色一情一区二区三区四区| 亚洲精品尤物av在线观看不卡| 亚欧成人中文字幕一区| 欧美午夜精品久久久久免费视| 国产精品人妻一区二区三区四| 日日鲁鲁鲁夜夜爽爽狠狠 | 男人的天堂av网站| 伊人精品成人久久综合| 精品国产天堂综合一区在线| 十八岁以下禁止观看黄下载链接| 国产色诱视频在线观看| 人妻换着玩又刺激又爽|