在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

VGF Antibody, Biotin conjugated

  • 中文名稱:
    VGF兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA025847LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) VGF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    NERP-1 antibody; NERP-2 antibody; Nerve growth factor inducible antibody; Neuroendocrine regulatory peptide-2 antibody; Neurosecretory protein VGF antibody; VGF antibody; VGF_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Neurosecretory protein VGF protein (23-206AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner. VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain.; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons.; Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons. Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus. Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying.; Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis. Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes. Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity.; Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation. Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization.; Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris.
  • 基因功能參考文獻:
    1. Results show that VGF is epigenetically modified in human non-small-cell lung cancer (NSCLC) tissues if compared to tumor-free lung tissues, which results in an increased transcription and protein expression. PMID: 29209432
    2. results suggest VGF enhances dendritic maturation and that these effects can be altered by common SNPs in the VGF gene PMID: 28287464
    3. We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity. PMID: 27088090
    4. Data show although no any significant differences between patient groups and lean subjects of proteins SYT4, BAG3, APOA1, and VAV3, except for VGF protein, there was a trend between the expression of these four genes and their protein levels. PMID: 26337083
    5. Data show that two VGF peptides (NAPP-19 and QQET-30) were identified in plasma. PMID: 26562304
    6. Data indicate an increased number of neurosecretory protein VGF-expressing T cells in patients with Alzheimer's disease (AD) compared to aged healthy controls. PMID: 26142708
    7. Results indicate that neuron-restrictive silencer factor plays an important role as a repressor of VGF gene regulation in neuroblastoma cells through a mechanism that is dependent on VGF-neuron-restrictive silencer element PMID: 25569790
    8. NERPs may be potent endogenous suppressors of glucose-dependent insulin secretion. PMID: 25529453
    9. DISC1 knockdown leads to a reduction of VGF in neurons. PMID: 24934694
    10. Knock-in mice expressing human VGF were fertile, had increased body weight, whereas those with c-terminal region deletion had reduced adiposity, increased energy expenditure, and improved glucose tolerance. PMID: 25675362
    11. We conclude that VGF contributes to survival and function of peripheral T cells PMID: 25013207
    12. Among the 19 genes tested, VGF was found to be completely methylated in several Urothelial Cell Carcinoma cell lines PMID: 24830820
    13. The expression of NPY and VGF was increased in the arcuate nucleus, but decreased in the nucleus of the Tractus Solitarius in the brains of type-II diabetic patients. PMID: 22808091
    14. [review] The vgf gene is induced in vivo by neurotrophins including nerve growth factor (NGF), brain derived growth factor (BDNF) and glial derived growth actor (GDNF), by synaptic activity and by homeostatic and other stimuli. PMID: 21621608
    15. VGF is regulated by SOD1 and plays a critical role in motor neuron survival PMID: 21151573
    16. localization of neuroendocrine regulatory peptide-1 and-2 (NERP-1 and NERP-2); results suggest that neuroendocrine NERP-1 and NERP-2 might function as local modulatorsin the neuroendocrine system PMID: 20471433
    17. VGF is downregulated in bipolar disorder in the CA region of the hippocampus and Brodmann's area 9 of the prefrontal cortex. PMID: 20631166
    18. VGF mRNA levels were significantly reduced in drug-free depressed patients, as compared with controls, and were modulated in response to effective antidepressant treatment. PMID: 20164831
    19. Application of neurosecretory protein VGF biomarker model to current diagnostic criteria provides an objective biomarker pattern that identifies patients with amyotrophic lateral sclerosis. PMID: 16481598
    20. proVGF-related peptides are present in endocrine cells early during development and adulthood and increase in hyperplasia and tumors PMID: 17440014
    21. while Vgf may be a reliable biomarker of progression of muscle weakness in patients with ALS, restoration of Vgf expression in spinal cord motor neurons may therapeutically rescue spinal cord motorneurons against excitotoxic injury PMID: 18432310

    顯示更多

    收起更多

  • 亞細胞定位:
    [Neurosecretory protein VGF]: Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus.
  • 組織特異性:
    Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells.
  • 數據庫鏈接:

    HGNC: 12684

    OMIM: 602186

    KEGG: hsa:7425

    STRING: 9606.ENSP00000249330

    UniGene: Hs.587325



主站蜘蛛池模板: 好湿好紧太硬了我太爽了视频| 成人a毛片视频免费看| 人妻人人做人做人人爱| 高潮又爽又无遮挡又免费| 日本黄网站三级三级三级| 中文在线а天堂| 国产亚洲精品无码不卡| 国产高清一区二区三区直播| 国产女人高潮抽搐喷水视频| 国产精品女主播在线视频| 在线视频精品免费观看10| 国产美女久久精品香蕉| 欧美精品亚洲精品日韩专区一乛方| 人妻无码精品久久亚瑟影视| 茄子视频国产在线观看| 一本久久知道综合久久| 女被男啪到哭的视频网站| 国产舌乚八伦偷品w中| 国产男女爽爽爽免费视频| 四虎免费最新在线永久4hu| 亚洲卡1卡2卡新区网站| 亚洲精品无码久久毛片| 欧美最猛性xxxxx大叫| 在线视+欧美+亚洲日本| 怡红院av一区二区三区| 国产精品18久久久久久麻辣| 中文字幕无码日韩专区免费| 久草热8精品视频在线观看| 精品一区二区三区免费毛片爱| 国产精品视频| 97精品一区二区视频在线观看| 亚洲乱亚洲乱妇24p| 久久人妻无码aⅴ毛片a片app| 99精品热在线在线观看视频| 国产成人无码av大片大片在线观看| 久99久热只有精品国产15| 夫妇交换性三中文字幕| 无码国产精品一区二区色情男同 | 天天操夜夜操| 国产成人无码精品一区二区三区| 野外少妇激情aa 级视频|