在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UXT Antibody

  • 中文名稱:
    UXT兔多克隆抗體
  • 貨號:
    CSB-PA880062ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA880062ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA880062ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UXT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UXT
  • 別名:
    Androgen receptor trapped clone 27 protein antibody; ART 27 antibody; ART-27 antibody; OTTHUMP00000023226 antibody; OTTHUMP00000023227 antibody; Protein UXT antibody; SKP2 associated alpha PFD 1 antibody; STAP1 antibody; Ubiquitously expressed prefoldin like chaperone antibody; Ubiquitously expressed transcript antibody; Ubiquitously expressed transcript protein antibody; Uxt antibody; UXT_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein UXT protein (1-157AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.; Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.
  • 基因功能參考文獻:
    1. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. PMID: 28106301
    2. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
    3. we describe the identification of UXT as a novel MDMX-interacting protein PMID: 25974965
    4. UXT is a binding protein of PIAS2, and interaction between PIAS2 and UXT may be important for the transcriptional activation of AR. PMID: 25434787
    5. Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. PMID: 24743694
    6. Knockdown of UXT expression in Treg cells results in a less-suppressive phenotype. PMID: 24136450
    7. Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis. PMID: 24021647
    8. Epstein-Barr virus BGLF4 kinase downregulates NF-kappaB transactivation through phosphorylation of coactivator UXT PMID: 22933289
    9. Loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression, and nuclear ART-27 expression was lost in the majority of AR-positive recurrent prostate cancers. PMID: 19318562
    10. UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction. PMID: 22131337
    11. these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway. PMID: 21907703
    12. Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes. PMID: 21730289
    13. Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation. PMID: 21307340
    14. decreased levels of ART-27 protein in prostate cancer tissue may occur as a result of de-differentiation, and indicate that ART-27 is likely to regulate a subset of AR-responsive genes important to prostate growth suppression and differentiation. PMID: 14711828
    15. UXT is a component of centrosome and is essential for cell viability and may facilitate transformation by corrupting regulated centrosome functions. PMID: 16221885
    16. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria. PMID: 17554592
    17. UXT is a novel and essential cofactor in the NF-kappa B transcriptional enhanceosome. PMID: 17620405
    18. UXT suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like ecotropic viral integration site 1 PMID: 17635584
    19. propose a transcriptional regulatory circuit for the developmental expression of ART-27 that includes repression by chromatin modification through a trichostatin A-sensitive factor and activation upon growth factor stimulation via CREB PMID: 17761951
    20. Is part of an RNA polymerase II-associated complex with possible chaperone activity. PMID: 19450687
    21. UXT was identified in a screen for proteins that interact with the Androgen Receptor N-terminal activation domain. We termed the protein Androgen Receptor Trapped clone 27 (ART-27). ART-27 appears to function as a transcriptional coactivator protein. PMID: 11854421

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cytoplasm.; Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族:
    UXT family
  • 組織特異性:
    Ubiquitous. Expressed in prostate epithelial cells. Expressed in mammary epithelial cells. Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest
  • 數據庫鏈接:

    HGNC: 12641

    OMIM: 300234

    KEGG: hsa:8409

    STRING: 9606.ENSP00000337393

    UniGene: Hs.172791



主站蜘蛛池模板: 国产av大陆精品一区二区三区| 88国产精品视频一区二区三区| 波多野结衣在线播放| 国产精品无码a∨精品影院app| 久久久久四虎精品免费入口| 日韩精品成人av在线观看| 欧美精品videosex极品| 少妇性l交大片毛多| 色avav色av爱avav亚洲色拍| 亚洲国产桃花岛一区二区| 婷婷成人综合激情在线视频播放| 欧洲多毛裸体xxxxx| 伊人无码一区二区三区| 色屁屁www影院免费观看| 亚洲日韩欧美国产高清αv| 少妇又爽又刺激视频| 黑人强伦姧人妻久久| 性色av无码专区一ⅴa亚洲| 中文无码日韩欧免费视频 | 国内免费视频成人精品| 无码乱人伦一区二区亚洲| 亚洲大尺度无码无码专线一区| 国产精品人妻久久毛片| 一本清日本在线视频精品| 一二区成人影院电影网| 欧美日韩国产免费一区二区三区| 国产精品青青在线观看爽| 男人边吃奶边揉好爽免费视频| 超清av在线播放不卡无码| 精品国内自产拍在线播放观看| 国产一卡2卡3卡4卡精品| 日日碰狠狠添天天爽无码| 欧美猛少妇色xxxxx猛叫| 77777亚洲午夜久久多喷| 九九久久精品国产| 国产老妇伦国产熟女老妇视频| 日本高清www午色夜在线视频| 欧洲国产精品无码专区影院| 精品熟女少妇av免费观看| 精品久久久久久无码人妻蜜桃 | 国产精品 中文字幕 亚洲 欧美 |