在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. UXT Antibody

UXT Antibody

  • 中文名稱：
    UXT兔多克隆抗體
  • 貨號(hào)：
    CSB-PA935779
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA935779(UXT Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    UXT
  • 別名：
    Androgen receptor trapped clone 27 protein antibody; ART 27 antibody; ART-27 antibody; OTTHUMP00000023226 antibody; OTTHUMP00000023227 antibody; Protein UXT antibody; SKP2 associated alpha PFD 1 antibody; STAP1 antibody; Ubiquitously expressed prefoldin like chaperone antibody; Ubiquitously expressed transcript antibody; Ubiquitously expressed transcript protein antibody; Uxt antibody; UXT_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Full length fusion protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:20-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in gene transcription regulation. Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription. Together with URI1, associates with chromatin to the NKX3-1 promoter region. Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm. May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity. Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC. Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM.; Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP.
  • 基因功能參考文獻(xiàn)：
    1. UXT Is a LOX-PP Interacting Protein That Modulates Estrogen Receptor Alpha Activity in Breast Cancer Cells. PMID: 28106301
    2. EZH1, SUZ12 and UXT work synergistically to regulate pathway activation in the nucleus. PMID: 27127229
    3. we describe the identification of UXT as a novel MDMX-interacting protein PMID: 25974965
    4. UXT is a binding protein of PIAS2, and interaction between PIAS2 and UXT may be important for the transcriptional activation of AR. PMID: 25434787
    5. Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. PMID: 24743694
    6. Knockdown of UXT expression in Treg cells results in a less-suppressive phenotype. PMID: 24136450
    7. Data found that the UXT isoforms elicit dual opposing regulatory effects on SARM-induced apoptosis. PMID: 24021647
    8. Epstein-Barr virus BGLF4 kinase downregulates NF-kappaB transactivation through phosphorylation of coactivator UXT PMID: 22933289
    9. Loss of ART-27 enhances expression of many androgen-regulated genes, suggesting that ART-27 inhibits gene expression, and nuclear ART-27 expression was lost in the majority of AR-positive recurrent prostate cancers. PMID: 19318562
    10. UXT-V1 represents a novel integral component of the MAVS signalosome on mitochondria, mediating the innate antiviral signal transduction. PMID: 22131337
    11. these results suggest that Als2 is a binding partner of Uxt and Als2/Uxt interaction could be important for the activation of Nf-kappaB pathway. PMID: 21907703
    12. Data show that while Art-27 can bind AR directly, URI is bound to chromatin prior to hormone-dependent recruitment of AR, suggesting a role for URI in modulating AR recruitment to target genes. PMID: 21730289
    13. Ubiquitously expressed transcript, UXT-V1, is a novel regulator of TNF-induced apoptosis. It protects cells against TNF-induced apoptosis through modulating complex II formation. PMID: 21307340
    14. decreased levels of ART-27 protein in prostate cancer tissue may occur as a result of de-differentiation, and indicate that ART-27 is likely to regulate a subset of AR-responsive genes important to prostate growth suppression and differentiation. PMID: 14711828
    15. UXT is a component of centrosome and is essential for cell viability and may facilitate transformation by corrupting regulated centrosome functions. PMID: 16221885
    16. Increasing concentrations of UXT contributes to progressive aggregation of mitochondria. PMID: 17554592
    17. UXT is a novel and essential cofactor in the NF-kappa B transcriptional enhanceosome. PMID: 17620405
    18. UXT suppresses cell transformation and might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like ecotropic viral integration site 1 PMID: 17635584
    19. propose a transcriptional regulatory circuit for the developmental expression of ART-27 that includes repression by chromatin modification through a trichostatin A-sensitive factor and activation upon growth factor stimulation via CREB PMID: 17761951
    20. Is part of an RNA polymerase II-associated complex with possible chaperone activity. PMID: 19450687
    21. UXT was identified in a screen for proteins that interact with the Androgen Receptor N-terminal activation domain. We termed the protein Androgen Receptor Trapped clone 27 (ART-27). ART-27 appears to function as a transcriptional coactivator protein. PMID: 11854421

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasm.; Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole.
  • 蛋白家族：
    UXT family
  • 組織特異性：
    Ubiquitous. Expressed in prostate epithelial cells. Expressed in mammary epithelial cells. Highest levels in the heart, skeletal muscle, pancreas, kidney, liver, adrenal gland, peripheral blood leukocytes, lymph node, prostate, and thyroid and the lowest
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 12641

    OMIM: 300234

    KEGG: hsa:8409

    STRING: 9606.ENSP00000337393

    UniGene: Hs.172791



主站蜘蛛池模板： 中文字幕精品久久久乱码乱码 | 日产精品高潮呻吟av久久| 97精品国产久热在线观看| 久热在线播放中文字幕| 久久久久久久人妻无码中文字幕爆| 国产精品毛片a∨一区二区三区 | 久久www色情成人免费| 成年黄页网站大全免费无码| 亚洲综合伊人久久大杳蕉| 免费毛片全部不收费的| 精品欧洲av无码一区二区三区| 精品国产乱码久久久久久夜深人妻| 亚洲人成在线观看影院牛大爷| 欧美日韩亚洲国产欧美电影 | 色爱区综合五月激情| 2020最新无码国产在线观看| 久久精品人人做人人综合| 国产 | 久你欧洲野花视频欧洲1| 国精品无码一区二区三区在线| 亚洲精品suv精品一区二区| 日韩免费无码专区精品观看| 最近中文字幕在线中文视频| 狠狠做深爱婷婷丁香综合| 丰满又黄又爽少妇毛片| 特黄特色大片免费播放器图片| 牛和人交xxxx欧美| 国产美女被遭强高潮网站下载| 日韩精品成人av在线观看| 综合 欧美 亚洲日本| 亚洲性色av一区二区三区| 热99re久久国超精品首页| 无码毛片内射白浆视频| 亚洲中文字幕无码专区| 久久婷婷综合缴情亚洲狠狠_| 欧美变态口味重另类在线视频| 丰满人妻熟妇乱又伦精品视| 久久这里只精品国产免费9| 顶级欧美做受xxx000| 国产精品婷婷久久爽一下| 一本一道vs无码中文字幕| 亚洲精品久久av无码麻|