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  4. UVSSA Antibody, Biotin conjugated

UVSSA Antibody, Biotin conjugated

  • 中文名稱：
    UVSSA兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA012267LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UVSSA Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UVSSA
  • 別名：
    hypothetical protein LOC57654 antibody; K1530_HUMAN antibody; KIAA1530 antibody; Uncharacterized protein KIAA1530 antibody; UV stimulated scaffold protein A antibody; UVSS3 antibody; UVSSA antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human UV-stimulated scaffold protein A protein (143-206AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Factor involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. TC-NER allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Acts by promoting stabilization of ERCC6 by recruiting deubiquitinating enzyme USP7 to TC-NER complexes, preventing UV-induced degradation of ERCC6 by the proteasome. Interacts with the elongating form of RNA polymerase II (RNA pol IIo) and facilitates its ubiquitination at UV damage sites, leading to promote RNA pol IIo backtracking to allow access to the nucleotide excision repair machinery. Not involved in processing oxidative damage.
  • 基因功能參考文獻：
    1. Data suggest that a common TFIIH subunit p62 recruitment mechanism is shared by UV-stimulated scaffold protein A (UVSSA) in transcription-coupled repair (TCR) and xeroderma pigmentosum, complementation group C protein (XPC) in global genome repair (GGR). PMID: 29069470
    2. stabilization of UVSSA by interaction with USP7 is essential for Transcription-coupled Nucleotide Excision Repair PMID: 27129218
    3. UVSSA together with USP7 is implicated in regulating transcription-coupled DNA repair.[review] PMID: 23760561
    4. Human UVSSA protein is required for the ubiquitination of RNA polymerase and DNA repair after light-induced DNA damage [review]. PMID: 23631307
    5. KIAA1530 is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome. PMID: 22902626
    6. Mutations in the UVSSA gene is associated with UV-sensitive syndrome. PMID: 22466610
    7. Mutations in UVSSA cause UV-sensitive syndrome and recruits USP7 to regulate transcription-coupled repair. PMID: 22466611
    8. Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair. PMID: 22466612

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  • 相關疾病：
    UV-sensitive syndrome 3 (UVSS3)
  • 亞細胞定位：
    Chromosome.
  • 蛋白家族：
    UVSSA family
  • 數據庫鏈接：

    HGNC: 29304

    OMIM: 614632

    KEGG: hsa:57654

    STRING: 9606.ENSP00000374501

    UniGene: Hs.380475



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