在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP30 Antibody

USP30 Antibody

  • 中文名稱：
    USP30兔多克隆抗體
  • 貨號：
    CSB-PA765106LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human Kidney tissue using CSB-PA765106LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA765106LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品描述：

    The polyclonal antibody against USP30 was created in rabbits through immunization with recombinant human USP30 protein containing amino acids 101-400. This USP30 polyclonal antibody is only reactive with USP30 protein from human samples. The deubiquitinase enzyme USP30 is responsible for the regulation of protein turnover and maintenance of mitochondrial function.

    The USP30 antibody has been purified via protein G affinity chromatography, achieving more than 95% purity. Its validation in ELISA and IHC applications has further enhanced its versatility in experimental settings.

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP30 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Deubiquitinating enzyme 30 antibody; FLJ40511 antibody; Ub-specific protease 30 antibody; Ubiquitin carboxyl terminal hydrolase 30 antibody; Ubiquitin carboxyl-terminal hydrolase 30 antibody; Ubiquitin specific peptidase 30 antibody; Ubiquitin specific processing protease 30 antibody; Ubiquitin thioesterase 30 antibody; Ubiquitin thiolesterase 30 antibody; Ubiquitin-specific-processing protease 30 antibody; UBP30_HUMAN antibody; usp30 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，USP30 Antibody (CSB-PA765106LA01HU)，的標記方式是Non-conjugated。對于USP30 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA765106LB01HU USP30 Antibody, HRP conjugated ELISA
    FITC CSB-PA765106LC01HU USP30 Antibody, FITC conjugated
    Biotin CSB-PA765106LD01HU USP30 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
  • 基因功能參考文獻：
    1. the role of USP30 in the dynamic networks of mitochondrial quality control and its physiological implications. PMID: 29178074
    2. Here the authors report crystal structures of human USP30 bound to monoubiquitin and Lys6-linked diubiquitin, which explain how USP30 achieves Lys6-linkage preference through unique ubiquitin binding interfaces. PMID: 28945249
    3. show that USP30 delays mitophagy by delaying PARK2 recruitment to the mitochondria during mitophagy PMID: 25915564
    4. These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy. PMID: 25739811
    5. The mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated. PMID: 25621951
    6. reducing USP30 activity enhances mitochondrial degradation in neurons PMID: 24896179
    7. USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination. PMID: 18287522

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Expressed in skeletal muscle, pancreas, liver and kidney.
  • 數據庫鏈接：

    HGNC: 20065

    OMIM: 612492

    KEGG: hsa:84749

    STRING: 9606.ENSP00000257548

    UniGene: Hs.486434



主站蜘蛛池模板： 装睡被陌生人摸出水好爽| 国产精品熟女高潮视频| av无码中出一区二区三区| 欧美99久久无码一区人妻a片| 日本精品aⅴ一区二区三区| 国产sm调教折磨视频失禁| 99国产精品久久久久久久成人 | 久久99精品国产麻豆| 亚洲a无码综合a国产av中文| awww在线天堂bd资源在线| 中文字幕+乱码+中文乱码www| 日本成熟老妇乱| 中文字幕色av一区二区三区| 中文字幕人妻熟女人妻| 国产午夜无码片在线观看| 国产亚洲精品久久久久久彩霞 | 久久久国产精品亚洲一区| 精品国产乱码久久久久久影片| 日韩精品无码一区二区三区久久久 | 久久久久爽爽爽爽一区老女人| 国产人妻鲁鲁一区二区| 99精品久久久久久久婷婷| 久久人人爽人人爽人人片av麻烦 | 又色又爽又高潮免费视频国产| 亚洲色欲久久久久综合网| 亚洲成a人片77777kkkk| 国产精品天干天干有线观看| 无码日韩精品一区二区免费暖暖 | 欧美极p品少妇的xxxxx| 欧美成人精精品一区二区| 国产三级久久久精品麻豆三级| 欧美国产成人精品一区二区三区 | 亚洲精品一区二区三区中文字幕 | 欧美亚洲另类丝袜综合网| 99视频精品全部免费免费观看| 男人的天堂av社区在线| 亚洲第一狼人天堂久久| 2020年最新国产精品正在播放| 女人被狂c到高潮视频网站| 一本久久a久久免费精品不卡| 国产成人精品自在线导航|