在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. USP30 Antibody

USP30 Antibody

  • 中文名稱：
    USP30兔多克隆抗體
  • 貨號：
    CSB-PA004395
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HeLa cells using USP30 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Deubiquitinating enzyme 30 antibody; FLJ40511 antibody; Ub-specific protease 30 antibody; Ubiquitin carboxyl terminal hydrolase 30 antibody; Ubiquitin carboxyl-terminal hydrolase 30 antibody; Ubiquitin specific peptidase 30 antibody; Ubiquitin specific processing protease 30 antibody; Ubiquitin thioesterase 30 antibody; Ubiquitin thiolesterase 30 antibody; Ubiquitin-specific-processing protease 30 antibody; UBP30_HUMAN antibody; usp30 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the N-terminal region of Human USP30.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
  • 基因功能參考文獻：
    1. the role of USP30 in the dynamic networks of mitochondrial quality control and its physiological implications. PMID: 29178074
    2. Here the authors report crystal structures of human USP30 bound to monoubiquitin and Lys6-linked diubiquitin, which explain how USP30 achieves Lys6-linkage preference through unique ubiquitin binding interfaces. PMID: 28945249
    3. show that USP30 delays mitophagy by delaying PARK2 recruitment to the mitochondria during mitophagy PMID: 25915564
    4. These results provide the first evidence for a fundamental role of USP30 in determining the threshold for mitochondrial cell death and suggest USP30 as a potential target for combinatorial anti-cancer therapy. PMID: 25739811
    5. The mechanism by which parkin, an E3 ubiquitin ligase, and USP30, a mitochondrion-localized deubiquitylase, regulate mitophagy, was investigated. PMID: 25621951
    6. reducing USP30 activity enhances mitochondrial degradation in neurons PMID: 24896179
    7. USP30 participates in the maintenance of mitochondrial morphology, a finding that provides new insight into the cellular function of deubiquitination. PMID: 18287522

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion outer membrane.
  • 蛋白家族：
    Peptidase C19 family
  • 組織特異性：
    Expressed in skeletal muscle, pancreas, liver and kidney.
  • 數據庫鏈接：

    HGNC: 20065

    OMIM: 612492

    KEGG: hsa:84749

    STRING: 9606.ENSP00000257548

    UniGene: Hs.486434



主站蜘蛛池模板： 亚洲乱码中文字幕手机在线 | 日韩国产高清一区二区| 国产高清女同学巨大乳在线观看| 免费国产污网站在线观看| 人人妻人人澡人人爽人人精品 | 日韩中文高清在线专区| 狠狠亚洲色一日本高清色| 99国产精品欧美一区二区三区| 99久热在线精品视频观看| 97人妻天天爽夜夜爽二区| 无码中出人妻中文字幕av| 亚洲精品中国国产嫩草影院美女| 天天摸夜夜摸夜夜狠狠摸| 丰满少妇高潮惨叫久久久一| 国产成人欧美日韩在线电影| 国产精品美女久久久久av爽李琼| 国产综合久久久久| 色欲天天婬色婬香综合网完整| 99久久精品费精品国产一区二| 亚洲精品无amm毛片| 伊人色综合久久天天| 国产精品女人呻吟在线观看| 美女又色又爽视频免费| 天天干天天射天天操| 在线亚洲高清揄拍自拍一品区| 久久99亚洲精品久久69| 亚洲精品中文字幕乱码| 国产熟妇勾子乱视频| 国产成人啪精品视频免费视频| 亚洲色成人www永久在线观看| 最新中文字幕av无码专区| 国产在热线精品视频99公交| 国产成年女人毛片80s网站| 性欧美暴力猛交69hd| 国产丝袜足j在线视频播放| 正在播放熟妇群老熟妇456 | 国产成人亚洲精品无码蜜芽| 国产99在线 | 中国| 女人下边被添全过视频| 成人区精品一区二区不卡| 大伊香蕉精品一区二区|