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USP3 Antibody

  • 中文名稱：
    USP3兔多克隆抗體
  • 貨號：
    CSB-PA896756LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA896756LA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA896756LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) USP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Deubiquitinating enzyme 3 antibody; EC 3.1.2.15 antibody; SIH003 antibody; Ubiquitin carboxyl-terminal hydrolase 3 antibody; Ubiquitin specific peptidase 3 antibody; Ubiquitin specific processing protease 3 antibody; Ubiquitin Specific Protease 3 antibody; Ubiquitin thioesterase 3 antibody; Ubiquitin thiolesterase 3 antibody; Ubiquitin-specific-processing protease 3 antibody; UBP antibody; UBP3_HUMAN antibody; Usp3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 protein (201-500AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，USP3 Antibody (CSB-PA896756LA01HU)，的標記方式是Non-conjugated。對于USP3 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA896756LB01HU USP3 Antibody, HRP conjugated ELISA
    FITC CSB-PA896756LC01HU USP3 Antibody, FITC conjugated
    Biotin CSB-PA896756LD01HU USP3 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
  • 基因功能參考文獻：
    1. Data found that USP3 was overexpressed in gastric cancer (GC) tissues and cells. USP3 overexpression can be a useful biomarker for predicting the outcomes of GC patients. Moreover, USP3 was shown to influence cell proliferation by regulating cell cycle control and metastasis-related proteins. In vivo experiments showed that USP3 promoted GC tumor growth and metastasis. PMID: 30168892
    2. Depletion of USP3 lead to accelerated degradation of p53 in normal cells thereby enhanced cell proliferation and transformation. Reconstitution of wildtype USP3, but not the USP3 C168S mutant, restored the stability of p53 protein and inhibited cell proliferation and transformation. PMID: 28807825
    3. Taken together, the results suggested that USP3 is a negative regulator of ubiquitination signaling, counteracting RNF168- and RNF8-mediated ubiquitination. PMID: 24196443
    4. the role of UCP3 gene in functional status and survival at old age. PMID: 22743239
    5. Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20445134
    6. Ubiquitin-specific protease 3 (USP3) is a deubiquitinating enzyme for monoubiquitinated histones H2A and H2B; USP3 dynamically associates with chromatin and deubiquitinates H2A/H2B in vivo. PMID: 17980597

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  • 亞細胞定位：
    Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
  • 蛋白家族：
    Peptidase C19 family, USP3 subfamily
  • 組織特異性：
    Expressed in all tissues examined, with strongest expression in pancreas.
  • 數據庫鏈接：

    HGNC: 12626

    OMIM: 604728

    KEGG: hsa:9960

    STRING: 9606.ENSP00000369681

    UniGene: Hs.458499



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