在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UPF3B Antibody, HRP conjugated

  • 中文名稱:
    UPF3B兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA883646LB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) UPF3B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UPF3B
  • 別名:
    UPF3B antibody; RENT3B antibody; UPF3X antibody; Regulator of nonsense transcripts 3B antibody; Nonsense mRNA reducing factor 3B antibody; Up-frameshift suppressor 3 homolog B antibody; hUpf3B antibody; Up-frameshift suppressor 3 homolog on chromosome X antibody; hUpf3p-X antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Regulator of nonsense transcripts 3B protein (319-423AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
  • 基因功能參考文獻(xiàn):
    1. The authors discovered that UPF3B (i) interacts with the release factors, (ii) delays translation termination and (iii) dissociates post-termination ribosomal complexes that are devoid of the nascent peptide. PMID: 28899899
    2. UPF3B gene mutation is associated with Lujan-Fryns syndrome. PMID: 26358559
    3. the neurodevelopmental phenotype of UPF3B missense mutation is caused by impairment of nonsense-mediated mRNA decay pathway function altering neuronal differentiation. PMID: 26012578
    4. These findings indicate that SATB2 activates UPF3B expression through binding to its promoter. PMID: 23925499
    5. Data indicate the mutation p.R430X of UPF3B gene as the genetic etiology in the mental retardation pedigree. PMID: 22957832
    6. results demonstrate that the UPF3B-dependent NMD pathway is a major regulator of the transcriptome and that its targets have important roles in neuronal cells. PMID: 22182939
    7. The two cases with renal dysplasia and developmental delay showed remarkable clinical variability despite having the same mutation in UPF3B. PMID: 22609145
    8. Our results demonstrate that in addition to Lujan-Fryns and FG syndromes, UPF3B protein truncation mutations can cause also nonspecific XLMR. PMID: 19238151
    9. 3.4 A resolution crystal structure of a minimal UPF3b-EJC assembly, consisting of the interacting domains of five proteins (UPF3b, MAGO, Y14, eIF4AIII, and Barentsz) together with RNA and adenylyl-imidodiphosphate PMID: 20479275
    10. A conserved domain of hUpf3b mediates an interaction with the EJC protein Y14. Y14 is required for nonsense-mediated decay induced by tethered hUpf3b. PMID: 12718880
    11. The protein region that mediates this interaction and discriminates between hUpf3a and hUpf3b in NMD function is located in the C-terminal domain and fully contained within a small sequence that is highly conserved in Upf3b but not Upf3a proteins PMID: 16601204
    12. UPF3B induces nonsense mediated decay in the cytoplasm PMID: 17194930
    13. Three mutations lead to the introduction of a premature termination codon and subsequent nonsense-mediated mRNA decay of mutant UPF3B mRNA. PMID: 17704778
    14. UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1. PMID: 18066079
    15. Results suggest that UPF3A levels are tightly regulated by a post-transcriptional switch to maintain appropriate levels of NMD substrates in cells containing different levels of UPF3B. PMID: 19503078
    16. binds to spliced mRNAs upstream of exon-exon junctions; is part of mRNP complexes that are ready for nuclear export and that participate in nonsense-mediated mRNA decay PMID: 11546873
    17. binds RNPS1 protein, part of the postsplicing complex deposited 5' to exon-exon junctions PMID: 11546874

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Mental retardation, X-linked, syndromic, 14 (MRXS14)
  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
  • 蛋白家族:
    RENT3 family
  • 組織特異性:
    Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 20439

    OMIM: 300298

    KEGG: hsa:65109

    STRING: 9606.ENSP00000276201

    UniGene: Hs.103832



主站蜘蛛池模板: 无码日韩精品一区二区免费暖暖| 成人午夜免费无码区| 2018av无码视频在线播放| 日本肉体裸xxxxbbbb| 国产美女裸体无遮挡免费视频 | 国产精品va在线观看h| 欧美视频专区一二在线观看| 东北女人啪啪对白| 亚洲精品第一国产综合亚av| 老湿机国产福利视频| 无码伊人66久久大杳蕉网站谷歌| 国产又粗又猛又黄又爽无遮挡| 亚洲一区av无码少妇电影| 亚洲熟妇av午夜无码不卡| 久久国产人妻一区二区| 欧洲精品99毛片免费高清观看| 国产内射999视频一区| 久久综合九色综合97伊人| 国产午夜鲁丝片av无码免费| 性高朝久久久久久久久久| 自拍性旺盛老熟女| 少妇被粗大的猛进69视频| 99国产成人精品视频| 伊人久久大香线蕉综合中文字幕 | 国产精品熟妇视频国产偷人| av无码人妻无码男人的天堂| av无码av不卡一区二区| 99精品视频九九精品视频| 国产99视频精品免费视看9 | 无码丰满熟妇bbbbxxx| 在线a亚洲视频播放在线观看| 中国国产免费毛卡片| 少妇人妻中文字幕污| 人妻熟女一区二区aⅴ千叶宁真| 少妇人妻精品一区二区| 2021国产精品香蕉在线观看| 国产在线永久视频| 亚洲日韩va无码中文字幕| 国产在线观看精品一区二区三区| 综合 欧美 小说 另类 图| 熟女人妻水多爽中文字幕|