在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

UPF3B Antibody, Biotin conjugated

  • 中文名稱:
    UPF3B兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA883646LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UPF3B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UPF3B
  • 別名:
    UPF3B antibody; RENT3B antibody; UPF3X antibody; Regulator of nonsense transcripts 3B antibody; Nonsense mRNA reducing factor 3B antibody; Up-frameshift suppressor 3 homolog B antibody; hUpf3B antibody; Up-frameshift suppressor 3 homolog on chromosome X antibody; hUpf3p-X antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Regulator of nonsense transcripts 3B protein (319-423AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF2 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA upstream of exon-exon junctions. In vitro, stimulates translation; the function is independent of association with UPF2 and components of the EJC core.
  • 基因功能參考文獻:
    1. The authors discovered that UPF3B (i) interacts with the release factors, (ii) delays translation termination and (iii) dissociates post-termination ribosomal complexes that are devoid of the nascent peptide. PMID: 28899899
    2. UPF3B gene mutation is associated with Lujan-Fryns syndrome. PMID: 26358559
    3. the neurodevelopmental phenotype of UPF3B missense mutation is caused by impairment of nonsense-mediated mRNA decay pathway function altering neuronal differentiation. PMID: 26012578
    4. These findings indicate that SATB2 activates UPF3B expression through binding to its promoter. PMID: 23925499
    5. Data indicate the mutation p.R430X of UPF3B gene as the genetic etiology in the mental retardation pedigree. PMID: 22957832
    6. results demonstrate that the UPF3B-dependent NMD pathway is a major regulator of the transcriptome and that its targets have important roles in neuronal cells. PMID: 22182939
    7. The two cases with renal dysplasia and developmental delay showed remarkable clinical variability despite having the same mutation in UPF3B. PMID: 22609145
    8. Our results demonstrate that in addition to Lujan-Fryns and FG syndromes, UPF3B protein truncation mutations can cause also nonspecific XLMR. PMID: 19238151
    9. 3.4 A resolution crystal structure of a minimal UPF3b-EJC assembly, consisting of the interacting domains of five proteins (UPF3b, MAGO, Y14, eIF4AIII, and Barentsz) together with RNA and adenylyl-imidodiphosphate PMID: 20479275
    10. A conserved domain of hUpf3b mediates an interaction with the EJC protein Y14. Y14 is required for nonsense-mediated decay induced by tethered hUpf3b. PMID: 12718880
    11. The protein region that mediates this interaction and discriminates between hUpf3a and hUpf3b in NMD function is located in the C-terminal domain and fully contained within a small sequence that is highly conserved in Upf3b but not Upf3a proteins PMID: 16601204
    12. UPF3B induces nonsense mediated decay in the cytoplasm PMID: 17194930
    13. Three mutations lead to the introduction of a premature termination codon and subsequent nonsense-mediated mRNA decay of mutant UPF3B mRNA. PMID: 17704778
    14. UPF2 and UPF3b cooperatively stimulate both ATPase and RNA helicase activities of UPF1. PMID: 18066079
    15. Results suggest that UPF3A levels are tightly regulated by a post-transcriptional switch to maintain appropriate levels of NMD substrates in cells containing different levels of UPF3B. PMID: 19503078
    16. binds to spliced mRNAs upstream of exon-exon junctions; is part of mRNP complexes that are ready for nuclear export and that participate in nonsense-mediated mRNA decay PMID: 11546873
    17. binds RNPS1 protein, part of the postsplicing complex deposited 5' to exon-exon junctions PMID: 11546874

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, X-linked, syndromic, 14 (MRXS14)
  • 亞細胞定位:
    Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm.
  • 蛋白家族:
    RENT3 family
  • 組織特異性:
    Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta.
  • 數據庫鏈接:

    HGNC: 20439

    OMIM: 300298

    KEGG: hsa:65109

    STRING: 9606.ENSP00000276201

    UniGene: Hs.103832



主站蜘蛛池模板: 2020年最新国产精品正在播放| 蜜桃臀无码内射一区二区三区| 97色伦图片97综合影院 | 日本簧片在线观看| 免费观看潮喷到高潮中文字幕| 亚洲无日韩码精品| 无码国产成人久久| 久久久99精品免费观看| 中文字字幕在线中文无码| 4480yy私人精品国产| 在线观看无码av免费不卡软件| 国产精品毛片无码| 欧洲多毛裸体xxxxx| 一边啪啪的一边呻吟声口述| 99精品国产福利一区二区| 亚洲色欲色欲大片www无码| 亚洲乱亚洲乱妇小说网| 99久久精品国产成人综合| 亚洲欧洲综合有码无码| 丰满少妇人妻无码专区 | 天堂www天堂在线资源| 亚洲成a人片在线观看无码专区| 国产精品久久..4399| 2019最新久久久视频精品| 人人妻人人澡人人爽欧美精品| 欧美mv日韩mv国产网站| 国产精品呻吟久久人妻无吗 | 亚洲精品无播放器在线播放| 牛和人交xxxx欧美| 国产成人无码18禁午夜福利网址| 精品精品国产理论在线观看| 宅女午夜福利免费视频| 成a人片亚洲日本久久| 九九线精品视频在线观看| 少妇裸体性生交| 天堂а√中文在线官网| 特黄特级毛片免费视频| 免费大片av手机看片不卡| 亚洲熟妇无码爱v在线观看| 午夜精品久久久内射近拍高清| 77se77亚洲欧美在线|