在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ULK3 Antibody

ULK3 Antibody

  • 中文名稱：
    ULK3兔多克隆抗體
  • 貨號：
    CSB-PA004389
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of 293 cells using ULK3 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ULK3
  • 別名：
    DKFZP434C131 antibody; FLJ90566 antibody; Serine/threonine-protein kinase ULK3 antibody; Ulk3 antibody; ULK3_HUMAN antibody; unc 51 like kinase 3 (C. elegans) antibody; Unc-51-like kinase 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human ULK3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
  • 基因功能參考文獻：
    1. Increased ULK3 also induces autophagy, which is unlinked from GLI and CAF activation. ULK3 upregulation occurs in the CAFs of several tumor types, and ULK3 silencing suppresses the tumor-enhancing properties of these cells. PMID: 28877478
    2. Structural and biochemical studies reveal an unusually tight interaction between ULK3 and IST1, an ESCRT-III subunit required for cytokinetic abscission. PMID: 26011858
    3. First named and identified as protein kinase of the ULK family PMID: 12471243
    4. Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway. PMID: 20643644
    5. serine/threonine kinase ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins PMID: 19878745

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
  • 組織特異性：
    Widely expressed. Highest levels observed in fetal brain. In adult tissues, high levels in brain, liver and kidney, moderate levels in testis and adrenal gland and low levels in heart, lung, stomach, thymus, prostate and placenta. In the brain, highest ex
  • 數據庫鏈接：

    HGNC: 19703

    OMIM: 613472

    KEGG: hsa:25989

    STRING: 9606.ENSP00000400312

    UniGene: Hs.513034



主站蜘蛛池模板： 人妻丰满熟妇av无码区乱| 丰腴饱满的极品熟妇| 国产亚洲精品久久777777| 精品视频无码一区二区三区| 亚洲中文无码人a∨在线导航| 波多野结衣网站| 国产av老师丝袜美腿丝袜| 亚洲а∨天堂久久精品| 免费一区二区无码东京热| 国产精品久久久久久久久久免费看| 色婷婷综合中文久久一本| 欧美一夜爽爽爽爽爽爽| 亚洲国产高清在线一区二区三区| 在线无码免费的毛片视频| 久久久久久综合岛国免费观看| mm1313亚洲国产精品无码试看| 精品无码黑人又粗又大又长| 国产亚洲精品久久久久久大师 | 在线观看国产精品av| 久久一本人碰碰人碰| 国产免费视频| 久久青青草原国产免费播放 | 欧美大片va欧美在线播放| 麻豆av字幕无码中文| 国内高清a自拍视频| 国产成人无码a区在线观看视频| 波多野结衣中文字幕一区二区三区| 国产成a人亚洲精品无码樱花| 国产成人精品自在线导航| 青楼妓女禁脔道具调教sm| 精品国产一区二区三区久久久狼| 国产精品兄妹在线观看麻豆| 久久精品国产99国产精2020丨 | av无码中出一区二区三区| 欧美自拍另类欧美综合图片区| 免费无码黄网站在线看| 夜夜爽一区二区三区精品| 欧美一道本一区二区三区| 蜜臀视频一区二区在线播放 | 免费情侣作爱视频| 无码人妻丝袜在线视频红杏|