在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ULK2 Antibody

ULK2 Antibody

  • 中文名稱：
    ULK2兔多克隆抗體
  • 貨號：
    CSB-PA811629LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: SH-SY5Y whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate
      All lanes: ULK2 antibody at 2.9µg/ml
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 113 kDa
      Observed band size: 113 kDa
    • IHC image of CSB-PA811629LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA811629LA01HU diluted at 1:400 and staining in paraffin-embedded human glioma performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ULK2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    ATG1B antibody; KIAA0623 antibody; Serine/threonine protein kinase ULK2 antibody; Serine/threonine-protein kinase ULK2 antibody; ULK2 antibody; ULK2_HUMAN antibody; Unc 51 (C. elegans) like kinase 2 antibody; Unc 51 like autophagy activating kinase 2 antibody; Unc 51 like kinase 2 antibody; Unc-51-like kinase 2 antibody; Unc51.2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Serine/threonine-protein kinase ULK2 protein (211-276AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，ULK2 Antibody (CSB-PA811629LA01HU)，的標記方式是Non-conjugated。對于ULK2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA811629LB01HU ULK2 Antibody, HRP conjugated ELISA
    FITC CSB-PA811629LC01HU ULK2 Antibody, FITC conjugated
    Biotin CSB-PA811629LD01HU ULK2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
  • 基因功能參考文獻：
    1. MiRNA-26b may play a key role in cell growth and death of laryngeal carcinoma through ULK2 and the PTEN/AKT pathway. PMID: 28713931
    2. The serine/threonine kinase ULK2 binds to and phosphorylates CARMA2sh. PMID: 28230860
    3. Knockdown of ULK2 expression significantly induced autophagy, EMT, and cell migration in lung cancer cell line. PMID: 27062295
    4. miR-26b was down-regulated in LNCaP, DU145, C4-2 and PC-3 cells compared to the two normal prostate cells RWPE-1 and WPMY-1 except DU145 cells. This inversely correlates with ULK2 level in the same cell lines. PMID: 26920049
    5. Kapbeta2 interacts with ULK2 through ULK2's putative PY-NLS motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity. PMID: 26052940
    6. Glioblastoma and glioma cell lines had low levels of ULK2 transcripts. ULK2 promoter methylation and transcript levels showed significant negative correlation. PMID: 24923441
    7. First identification and naming of ULK2 as an ortholog of mouse ULK2. PMID: 12471243

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
  • 數據庫鏈接：

    HGNC: 13480

    OMIM: 608650

    KEGG: hsa:9706

    STRING: 9606.ENSP00000354877

    UniGene: Hs.168762



主站蜘蛛池模板： 妖精色av无码国产在线看| 噜噜久久噜噜久久鬼88| 无码免费h成年动漫在线观看 | 日韩不卡1卡2卡三卡2021精品推荐 | 午夜免费啪视频观看视频| 动漫无遮挡h纯肉亚洲资源大片| 亚洲a无码综合a国产av中文| 无码一区二区| 人妻无码一区二区不卡无码av| 乱码午夜-极国产极内射| 亚洲精品无码国产| 亚洲 欧美 动漫 少妇 自拍| 伊人久久大香线蕉av成人| 美女无遮挡免费视频网站| 日韩一本之道一区中文字幕| 亚洲中文色欧另类欧美| 青青草国产三级精品三级| 精品人妻av区波多野结衣 | 蜜桃av色偷偷av老熟女| 久久午夜私人影院| 亚洲精品无码中文久久字幕| 欧美性猛交xxxx乱大交3| 疯狂撞击丝袜人妻| 国产黑色丝袜在线观看下| 18禁黄污无遮挡无码网站| 无码视频一区二区三区| 波多野结衣av无码| 国产粗话肉麻对白在线播放| 国产999久久高清免费观看| 亚洲欧洲中文日韩久久av乱码| 四川少妇大战4黑人| 国产成人福利美女观看视频| 18禁无遮挡无码国产免费网站| 亚洲a∨无码男人的天堂| 久久99国产精一区二区三区| 久久久久久伊人高潮影院| 久久久久蜜桃精品成人片公司| 精品国产乱码久久久久久郑州公司| 乱码视频午夜间在线观看| 老熟女老太婆爽| 韩国精品一区二区无码视频|