在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ULK2 Antibody

ULK2 Antibody

  • 中文名稱：
    ULK2兔多克隆抗體
  • 貨號：
    CSB-PA471712
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HELA cells using Antibody diluted at 500. Secondary antibody was diluted at 1:20000
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    ATG1B antibody; KIAA0623 antibody; Serine/threonine protein kinase ULK2 antibody; Serine/threonine-protein kinase ULK2 antibody; ULK2 antibody; ULK2_HUMAN antibody; Unc 51 (C. elegans) like kinase 2 antibody; Unc 51 like autophagy activating kinase 2 antibody; Unc 51 like kinase 2 antibody; Unc-51-like kinase 2 antibody; Unc51.2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide from Human protein at AA range: 930-1000
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS, pH 7.4, containing 0.5% BSA and 0.02% sodium azide as Preservative and 50% Glycerol.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-10000
    ELISA 1:10000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic pathways within developing axons.
  • 基因功能參考文獻：
    1. MiRNA-26b may play a key role in cell growth and death of laryngeal carcinoma through ULK2 and the PTEN/AKT pathway. PMID: 28713931
    2. The serine/threonine kinase ULK2 binds to and phosphorylates CARMA2sh. PMID: 28230860
    3. Knockdown of ULK2 expression significantly induced autophagy, EMT, and cell migration in lung cancer cell line. PMID: 27062295
    4. miR-26b was down-regulated in LNCaP, DU145, C4-2 and PC-3 cells compared to the two normal prostate cells RWPE-1 and WPMY-1 except DU145 cells. This inversely correlates with ULK2 level in the same cell lines. PMID: 26920049
    5. Kapbeta2 interacts with ULK2 through ULK2's putative PY-NLS motif, and facilitates transport from the cytoplasm to the nucleus, depending on its Ser1027 residue phosphorylation by PKA, thereby reducing autophagic activity. PMID: 26052940
    6. Glioblastoma and glioma cell lines had low levels of ULK2 transcripts. ULK2 promoter methylation and transcript levels showed significant negative correlation. PMID: 24923441
    7. First identification and naming of ULK2 as an ortholog of mouse ULK2. PMID: 12471243

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasmic vesicle membrane; Peripheral membrane protein. Note=Localizes to pre-autophagosomal membrane.
  • 蛋白家族：
    Protein kinase superfamily, Ser/Thr protein kinase family, APG1/unc-51/ULK1 subfamily
  • 數據庫鏈接：

    HGNC: 13480

    OMIM: 608650

    KEGG: hsa:9706

    STRING: 9606.ENSP00000354877

    UniGene: Hs.168762



主站蜘蛛池模板： 中年人妻丰满av无码久久不卡| 成人aa免费视频在线播放| 国产在线永久视频| 国产综合有码无码中文字幕| 麻豆蜜桃av蜜臀av色欲av| 久久综合88熟人妻| 亚洲中文无码av在线| 亚洲欧美日韩v在线观看不卡| 韩国午夜福利片在线| 亚洲午夜无码极品久久| 精品三级av无码一区| 无码精品人妻一区二区三区免费看| 人妻在卧室被老板疯狂进入| 日本一卡2卡3卡4卡免费乱码网站| 亚洲综合精品第一页| 亚洲 激情 小说 另类 欧美| 亚洲熟妇av乱码在线观看| 浴室人妻的情欲hd三级国产 | 亚洲无av在线中文字幕| 亚洲区激情区无码区日韩区| 国产精品a久久777777| 免费一区二区三区成人免费视频| 少妇又爽又刺激视频| 女人与拘性猛交视频| 激情偷乱人伦小说视频在线| 欧美人与性动交α欧美精品| 大战丰满无码人妻50p| 欧美日产欧美日产国产精品| 8ⅹ8x擦拨擦拨成人免费视频| 四虎成人精品在永久在线| 国产真实乱人偷精品视频| 久久国产36精品色熟妇| 久久久久无码国产精品一区| 性少妇无码播放| 久久久精品人妻无码专区不卡| 日韩人妻中文无码一区二区三区| 亚洲日韩精品无码专区加勒比海 | 中文字幕有码无码人妻在线| 全球成人中文在线| 无码精品国产一区二区免费| 性夜影院午夜看片|