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UBR2 Antibody

  • 中文名稱:
    UBR2兔多克隆抗體
  • 貨號:
    CSB-PA809001LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Western Blot
      All lanes: UBR2 antibody at 3µg/ml + Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 201, 50, 67 kDa
      Observed band size: 201 kDa
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) UBR2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    UBR2
  • 別名:
    UBR2 antibody; C6orf133 antibody; KIAA0349 antibody; E3 ubiquitin-protein ligase UBR2 antibody; EC 2.3.2.27 antibody; N-recognin-2 antibody; RING-type E3 ubiquitin transferase UBR2 antibody; Ubiquitin-protein ligase E3-alpha-2 antibody; Ubiquitin-protein ligase E3-alpha-II antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase UBR2 protein (101-439AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,UBR2 Antibody (CSB-PA809001LA01HU),的標記方式是Non-conjugated。對于UBR2 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA809001LB01HU UBR2 Antibody, HRP conjugated ELISA
    FITC CSB-PA809001LC01HU UBR2 Antibody, FITC conjugated
    Biotin CSB-PA809001LD01HU UBR2 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis. Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retrotransposon mobilization. Catalyzes ubiquitination and degradation of the N-terminal part of NLRP1 following NLRP1 activation by pathogens and other damage-associated signals: ubiquitination promotes degradation of the N-terminal part and subsequent release of the cleaved C-terminal part of NLRP1, which polymerizes and forms the NLRP1 inflammasome followed by host cell pyroptosis.
  • 基因功能參考文獻:
    1. There was a significant difference between the oligospermia men (oligospermia group) and the fertile men (control group) observed in this research that could indicate that the combined AT-TC-CC genotype in the UBR2 gene (rs16895863, rs373341, rs3749897 respectively) is a possible risk of idiopathic oligospermia for men in Sichuan, China. PMID: 26940145
    2. The c.1,066A>T variant in the UBR2 gene is associated with increased susceptibility to azoospermia caused by meiotic arrest. PMID: 21573678
    3. Study provides functional data for the mouse ubiquitin protein ligase E3 component n-recognin 2 protein. PMID: 14585983
  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    UBR1 family
  • 組織特異性:
    Broadly expressed, with highest levels in skeletal muscle, kidney and pancreas. Present in acinar cells of the pancreas (at protein level).
  • 數據庫鏈接:

    HGNC: 21289

    OMIM: 609134

    KEGG: hsa:23304

    STRING: 9606.ENSP00000361990

    UniGene: Hs.529925



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