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  4. UBE2V2 Antibody, Biotin conjugated

UBE2V2 Antibody, Biotin conjugated

  • 中文名稱：
    UBE2V2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA025484DD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) UBE2V2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    UBE2V2
  • 別名：
    1 alpha 25 dihydroxyvitamin D3 inducible antibody; DDVit 1 antibody; DDVIT1 antibody; EDAF-1 antibody; EDAF1 antibody; EDPF-1 antibody; EDPF1 antibody; Enterocyte differentiation associated factor EDAF 1 antibody; Enterocyte differentiation promoting factor antibody; Enterocyte differentiation-associated factor 1 antibody; Enterocyte differentiation-promoting factor 1 antibody; Methyl methanesulfonate sensitive 2 antibody; MMS 2 antibody; MMS2 antibody; MMS2 homolog antibody; UB2V2_HUMAN antibody; UBE2V 2 antibody; UBE2V2 antibody; Ubiquitin conjugating enzyme E2 variant 2 antibody; Ubiquitin conjugating enzyme E2v2 antibody; Ubiquitin-conjugating enzyme E2 variant 2 antibody; UEV 2 antibody; UEV2 antibody; Vitamin D3 inducible protein antibody; Vitamin D3-inducible protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ubiquitin-conjugating enzyme E2 variant 2 protein (2-145AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
  • 基因功能參考文獻：
    1. Functional analysis of selected regulated proteins revealed that knockdown of HNRPD, PHB2 and UB2V2 can increase HCMV replication, while knockdown of A4 and KSRP resulted in decreased HCMV replication. PMID: 25910425
    2. suppression of hMMS2 reverses L-OHP tolerance in differentiated human colorectal carcinoma cells by promoting apoptosis PMID: 24846979
    3. UBE2v2 signalling through PCNA ubiquitination is not required for immunoglobulin diversification in DT40 cells. PMID: 15725630
    4. Insight into the influence of protein dynamics on the affinity of ubiquitin for Mms2. PMID: 15952783
    5. Mms2 physical association with ubiquitin is correlated with its ability to promote Lys63-linked ubiquitin chain assembly PMID: 17964296
    6. These results point to a high level of redundancy in the DNA damage tolerance pathway and suggest the existence of another hMMS2 variant (hMMSv) or complex that can compensate for its loss. PMID: 18284681

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  • 蛋白家族：
    Ubiquitin-conjugating enzyme family
  • 組織特異性：
    Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues.
  • 數據庫鏈接：

    HGNC: 12495

    OMIM: 603001

    KEGG: hsa:7336

    STRING: 9606.ENSP00000428209

    UniGene: Hs.491695



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